个人简介
1986.07毕业于安徽师范大学化学系获学士学位，1989.07毕业于中国科学院昆明植物研究所获天然产物化学硕士学位，1995.08-1998.08在美国华盛顿大学化学系留学并从事博士学位论文研究，于1999.11获中国科学院植物学博士学位。1989.07-2004.01在中国科学院昆明植物研究所先后任实习研究员、助理研究员、副研究员和研究员，2004.2-2009.02任厦门大学生命科学学院教授，2009.03至今任山东大学药学院和生命科学学院微生物技术国家重点实验室教授。
近期论文
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1. Yong Han, Yan Wang, Simon Tombosa, Stephen Wright, Justin Huffman, Gary Yuen, Guoliang Qian, Fengquan Liu, Yuemao Shen*, Liangcheng Du*. Identification of a small molecule signaling factor that regulates the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes. Appl. Microbiol. Biotechnol. 2015, 99, 801-8111.
2. Zhenyu Li, Lejiao Jia, Jifeng Wang, Xingkang Wu, Guowei Shi, Chunhua Lu, Yuemao Shen*. Discovery of novel 17-phenylethylaminegeldanamycin derivatives as potent Hsp90 inhibitors. Chemical Biology & Drug Design 2015, 85, 181-188.
3. Yaoyao Li, Haotong Chen, Yanjiao Ding, Yunxuan Xie, Haoxin Wang, Ronald L. Cerny, Yuemao Shen*, Liangcheng Du*. Iterative assembly of two separate polyketide chains by the same single-module bacterial polyketide synthase in the biosynthesis of HSAF. Angewandte Chemie International Edition 2014, 53, 7524-7530.
4. Zhenyu Li, Lejiao Jia, Jifeng Wang, Xingkang Wu, Huilin Hao, Yunfei Wu, Hongjiao Xu, Zhen Wang, Guowei Shi, Chunhua Lu, Yuemao Shen*. Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors. European Journal of Medicinal Chemistry 2014, 87, 346-363.
5. Zhenyu Li, Lejiao Jia, Jifeng Wang, Xingkang Wu, Huilin Hao, Hongjiao Xu, Yunfei Wu, Guowei Shi, Chunhua Lu, Yuemao Shen*. Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors. European Journal of Medicinal Chemistry 2014, 85, 359-370.
6. Shanren Li, Haoxin Wang, Yaoyao Li, Jingjing Deng, Chunhua Lu, Yan Shen, Yuemao Shen*. Biosynthesis of hygrocins, antitumor naphthoquinone ansamycins produced by Streptomyces sp. LZ35. ChemBioChem 2014, 15, 94-102.
7. Jianfang Li, Chao Lv, Weiyang Sun, Zhenyu Li, Xiaowei Han, Yaoyao Li, Yuemao Shen*. Cytosporone B, an inhibitor of the Type III secretion system of Salmonella enterica Serovar Typhimurium. Antimicrob. Agents Chemother. 2013, 57, 2191-2198.
Jifeng Wang, Baobing Zhao, Yuting Yi, Wei Zhang, Xuan Wu, Lianru Zhang, Yuemao Shen*. Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-κB pathways. Biochem. Pharm. 2012, 84, 891-899.
8. Baobing Zhao, Huili Shen, Lianru Zhang, Yuemao Shen*. Gambogic acid activates AMP-activated protein kinase in mammalian cells. Biochem. Biophys. Res. Commun. 2012, 424, 100-104.
9. Yaoyao Li, Justin Huffman, Yu Li, Liangcheng Du*, Yuemao Shen*. 3-Hydroxylation of the polycyclic tetramate macrolactam in the biosynthesis of antifungal HSAF from Lysobacter enzymogenes C3. Med. Chem. Commun. 2012, 3, 982-986.
10. Qiang Chen, Tenghui Chen, Wenjiao Li, Wei Zhang, Jingwei Zhu, Yang Li, Yaojian Huang, Yuemao Shen*, Chundong Yu*. Mycoepoxydiene inhibits lipopolysaccharide-induced inflammatory responses through the of TRAF6 polyubiquitination. PLOS One 2012, 7 (9), e44890.
11. Wei Zhang, Yaoyao Li, Guoliang Qian, Yan Wang, Haotong Chen, Yuezhong Li, Fengquan Liu, Yuemao Shen*, Liangcheng Du*. Identification and characterization of the anti-MRSA WAP-8294A2 biosynthetic gene cluster from Lysobacter enzymogenes OH11. Antimicrob. Agents Chemother. 2011, 55, 5581-9.
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