任冬梅 - 山东大学

个人简介

1992年获山东医科大学学士学位，1995年获山东中医药大学硕士学位，2007年获山东大学博士学位。1995年至今于山东大学药学院工作，2005年5月-11月于国家药品审评中心任外聘审评员，2009年2月-2010年9月于美国亚利桑那大学药学院药理毒理系进行博士后研究工作。

研究领域

1.影响Nrf2-Keap1信号通路表达的天然产物分离及机制研究 2.天然产物用于化学预防及作用机制 3.中药新药产品开发与技术研究

近期论文

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1.Yang S, Shen T, Zhao LJ, Li C, Zhang Y, Lou HX, Ren DM*. (2014) Chemical constituents ofLobelia chinensis. Fitoterapia. 93, 168-174. 2. Shen T, Chen XM, Harder B, Long M, Wang XN, Lou HX, Wondark G, Ren DM*, Zhang D*. (2014) Plant extracts of the family Lauraceae: A potential resource for chemopreventive agents that activate the Nrf2/ARE pathway.Planta Med.80 (5), 426-434 3. Zhao LJ, Li C, Zhang Y, Wen Q, Ren DM*. (2014) Phytochemical and biological activities of an anticancer plant medicine:Brucea javanica.Anticancer Agent Me. 14 (3), 440-458. 4. Yang S, Li C, Wang SQ, Zhao LJ, Hou Z, Lou HX, Ren DM*. (2013) Chiral separation of two diastereomeric pairs of enantiomers of novel alkaloid-lignan hybrids fromLobelia chinensisand determination of the tentative absolute configuration.J Chromatogr A.1311, 134-139. 5. Yang S, Wang LM, Guo XJ, Lou HX and Ren DM*. (2013) A new flavonoid glycoside and other constituents fromDracocephalum moldavica.Nat. Prod. Res.27(3), 201-207 6. Wang LM, Wang SQ, Yang S, Guo XJ, Lou HX and Ren DM*. (2012) Phenolic alkaloids from the aerial parts ofDracocephalum heterophyllum. Phytochemistry. 82, 166-171. 7. Hu QW, Zhang DD, Wang LM, Lou HX, and Ren DM*. (2012) Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity.Food Chem. Toxicol.50, 1927-1932. 8. Ren DM, Villeneuve NF, Jiang T, Wu TD, Lau A, Toppin AH and Zhang DD*. (2011) Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism.Proc Natl Acad Sci U S A108 (4), 1433 – 8. 9. Wang LM and Ren DM*. (2010) Flavopiridol, the first cyclin-dependent kinase inhibitor: recent advances in combination chemotherapy.Mini-Rev Med Chem10, 1058-1070. 10. Ren DM, Guo HF, Yu WT, Wang SQ and Lou HX*. (2008) Stereochemistry of flavonoidal alkaloids fromDracocephalum rupestre.Phytochemistry69, 1425-1433.