王凤山 - 山东大学 - 国家糖工程技术研究中心

个人简介

1978年10月～1982年7月在山东医学院药学系学习，获学士学位；1983年～1986年在山东医科大学生化药学专业读研究生，获硕士学位；1995年～1996年在英国伦敦大学Imperial College研修；1998年~2001年在华东理工大学生物化工专业攻读博士，获博士学位。自1986年7月在现单位工作，先后任助教（1986）、讲师（1988）、副教授（1994）、教授（1998）。

研究领域

1. 生物技术药物研究 2. 酶与蛋白质的化学修饰研究 3. 多糖类药物研究

近期论文

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6. Jingzong Qi, Yizhao Li, Hongwei Zhang, Yanna Cheng, Yongfu Sun, Jichao Cao, Ying Zhao, Fengshan Wang*. A novel conjugate of low-molecular-weight heparin and Cu,Zn-superoxide dismutase: Study on its mechanism in preventing brain reperfusion injury after ischemia in gerbils. Brain Research, 2009, 1260: 76 – 83. 7. Yuhong Liu, Chunhui Liu, Haining Tan, Ting Zhao, Jichao Cao, Fengshan Wang*. Sulfation of a polysaccharide obtained from Phellinus ribis and potential biological activities of the sulfated derivatives. Carbohydrate Polymers, 2009, 77: 370–375. 8. Jinfeng Liu, Li Teng, Chunhui Liu, Likuan Hu, Yonggang Wang, Hong Liu, Fengshan Wang*. Augmented inhibitory effect of superoxide dismutase on superoxide anion release from macrophages by chemical modification with polysaccharide and attenuation effects on radiation-induced inflammatory cytokine expression in vitro. Journal of Drug Targeting, 2009, 17(6): 216-224. 9. Jinfeng Liu, Haining Tan, Yongfu Sun, Shuai Zhou, Jichao Cao, Fengshan Wang*. The preventive effects of heparin–superoxide dismutase on carbon tetrachloride-induced acute liver failure and hepatic fibrosis in mice. Mol Cell Biochem, 2009, 327:219–228. DOI 10.1007/s11010-009-0060-2 10. J.Z. Sheng, P.X. Ling*, X.Q. Zhu, X.P. Guo, T.M. Zhang, Y.L. He and F.S. Wang*. Use of induction promoters to regulate hyaluronan synthase and UDP-glucose-6-dehydrogenase ofStreptococcus zooepidemicus expression in Lactococcus lactis: a case study of the regulation mechanism of hyaluronic acid polymer. Journal of Applied Microbiology, 2009, 107: 136-144. doi:10.1111/j.1365-2672.2009.04185.x 11. Chunhui Liu, Xiaodong Li, Yuhua Li, You Feng and Fengshan Wang*. Stuctutural characterization and antimutagenic activity of a novel polysaccharide isolated from Sepiella maindroni ink. Food Chemistry, 2008, 110(4) : 807–813. 12. Huan-Li XU, Hai-Ning TAN, Feng-Shan WANG* and Wei TANG. Research Advances of Endostatin and its Short Internal Fragments. Current Protein & Peptide Science, 2008, 9(3):275-283. 13. Jun YAN, Sheng-Li CHEN, Xiao-Lin WANG, Wen ZHOU, Feng-Shan WANG*. Meta-Analysis of Tacrolimus Ointment for Atopic Dermatitis in Pediatric Patient. Pediatric Dermatology, 2008, 25(1): 117-120. 14. Demin Gao, Xulong Zhang, Jian Zhang, Jichao Cao, and Fengshan Wang*. Expression of Thymosin α1-thymopentin Fusion Peptide in Pichia pastoris and its Characterization. Arch Pharm Res, 2008, 31(11): 1471-1476. 15. Haining Tan, Shenglin Yang, You Feng, Chunhui Liu, Jichao Cao, Guoying Mu and Fengshan Wang*. Characterization and Secondary Structure Analysis of Endostatin Covalently Modified by Polyethylene Glycol and Low Molecular Weight Heparin. Journal of Biochemistry, 2008, 144(2): 207–213. 16. Yuhong Liu, Fengshan Wang*. Structural characterization of an active polysaccharide from Phellinus ribis. Carbohydrate Polymers, 2007, 70: 386-392 17. H. W. Zhang, F. S. Wang*, W. Shao, X. L. Zheng, J. Z. Qi, J. C. Cao, and T. M. Zhang. Characterization and Stability Investigation of Cu,Zn-Superoxide Dismutase Covalently Modified by Low Molecular Weight Heparin. Biochemistry (Moscow), 2006, Vol. 71, Suppl. 1, pp. S96-S100.