张娜 - 山东大学

个人简介

2006/9-至今，山东大学，药学院，教授 2006/3-2007/3，美国kansas大学，药学院，博士后 2003/9-2006/8，山东大学，药学院，副教授 1997/1-2003/8，山东大学，药学院，讲师 1995/7-1996/12，山东医科大学，药学院，助教

研究领域

1. 靶向纳米给药系统：主要进行靶向修饰纳米粒作为药物传递系统的研究。实验室开展的工作包括：通过合成、修饰聚合物获得新材料以制备新型纳米粒以及利用新的纳米制备技术构建新型纳米载体；纳米粒作为诊断治疗学载体的研究；纳米粒作为药物共载载体的研究；纳米粒作为化学免疫联合治疗载体的研究； 2. 生物药剂学与药物动力学：新药和新制剂的临床前生物药剂学与药物动力学研究

近期论文

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Shengjun Mu, Yongjun Liu, Tianqi Wang, Jing Zhang, Dandan Jiang, Xiaoyue Yu, Na Zhang*. Unsaturated nitrogen-rich polymer poly(L-histidine) gated reversibly switchable mesoporous silica nanoparticles using ‘‘graft to” strategy for drug controlled release, Acta Biomaterialia, 2017, 63:150–162. Yongjun liu, Xiaoyun Wu, Xiaohe sun, Dan Wang, Ying Zhong, Dandan Jiang, Tianqi Wang, Dexin Yu, Na Zhang*. Design, synthesis, and evaluation of VEGFR-targeted macromolecular MRI contrast agent based on biotin–avidin-specific binding. International Journal of Nanomedicine, 2017, 12:5039-5052. Tianqi Wang, Lixia Feng, Shaomei Yang, Yongjun Liu, Na Zhang*. Ceramide lipid-based nanosuspension for enhanced delivery of docetaxel with synergistic antitumor efficiency. Drug Delivery, 2017, 24(1):800. Tianqi Wang, Xiaoyue Yu, leiqiang han, Tingxian liu, Yongjun liu, Na Zhang*. Tumor microenvironment dual-responsive core–shell nanoparticles with hyaluronic acid-shield for efficient co-delivery of doxorubicin and plasmid DNA. International Journal of Nanomedicine, 2017, 12:4773-4788. Zhihui Su, Yanchao Liang, Yao Yao, Tianqi Wang and Na Zhang*. Polymeric complex micelles based on the double-hydrazone linkage and dual drug-loading strategy for pH-sensitive docetaxel delivery. Journal of Materials Chemistry B, 2016, 4:1122-1133. Bo Zhang, TianqiWang, Shaomei Yang, Yanan Xiao, Yunmei Song, Na Zhang*, Sanjay Garg.Development and evaluation of oxaliplatin and irinotecan co-loaded liposomes for enhanced colorectal cancer therapy, Journal of Controlled Release, 2016, 238: 10-21. Mingfang Wang, Tingxian Liu, Leiqiang Han, Wenwen Gao, Shaomei Yang and Na Zhang*. Functionalized O-carboxymethyl-chitosan / polyethylenimine based novel dual pH-responsive nanocarriers for controlled co-delivery of DOX and genes. Polymer Chemistry. 2015, 6:3324-3335 Yongjun Liu, Lixia Feng, Tingxian Liu, Li Zhang, Yao Yao, Dexin Yu, Linlin Wang and Na Zhang*. Multifunctional pH-sensitive polymeric nanoparticles for theranostics evaluated experimentally in cancer. Nanoscale, 2014, 6 (6), 3231-3242 Xiaoyan Yang, Yunxia Li, Min Li, Li Zhang, Lixia Feng, Na Zhang*.Hyaluronic acid coated nanostructured lipid carriers for targeting paclitaxel to cancer. Cancer Lett, 2013, 334: 338-345 Chunxi Liu, Fengxi Liu, Lixia Feng, Min Li, Jian Zhang, Na Zhang*.The targeted co-delivery of DNA and Doxorubicin to tumor cells via multifunctional PEI-PEG based nanoparticles. Biomaterials, 2013, 34, 2547-2564

学术兼职

现为山东省“国家重大新药创制平台”临床前药代动力学平台主任，山东大学临床前药代动力学平台主任； Journal of Nanoscience letter 杂志副主编； Journal of Biomedical Nanotechnology、Drug Discoveries & Therapeutics、Asian Journal of Pharmaceutical Sciences等杂志编委。