方浩 - 山东大学

个人简介

2007/9-至今，山东大学，药学院，教授 2004/12-2007/9，山东大学，药学院，副教授 2002/9-2004/12，美国北卡罗莱纳州立大学、佐治亚州立大学化学系博士后 2001/9-2002/8，美国密歇根大学药学院博士后 1996/9-2001/6，中国药科大学药物化学专业，博士研究生 1992/9-1996/6，中国药科大学化学制药专业，本科

研究领域

1.基于靶点结构的创新药物研究：主要针对恶性肿瘤和自身免疫性疾病等相关药物靶标，基于药物靶标结构和计算化学原理，开展分子设计、类药化合物合成及生物活性评价等方面的创新药物研究。 2.化学生物学：研究小分子化合物调控细胞凋亡及表观遗传等方面功能

近期论文

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Liang T, Zhou Y, Elhassan RM, Hou X, Yang X,Fang H*. HDAC-Bax Multiple Ligands Enhance Bax-Dependent Apoptosis in HeLa Cells.J. Med. Chem., 2020 Oct 22;63(20):12083-12099. Zhou Y, Liu X, Xue J, Liu L, Liang T, Li W, Yang X, Hou X, Fang H*. Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma. J. Med. Chem.,2020, 63, 4701-4715. Liang T, Xue J, Yao Z, Ye Y, Yang X, Hou X, Fang H. Design, synthesis and biological evaluation of 3, 4-disubstituted-imidazolidine-2, 5-dione derivatives as HDAC6 selective inhibitors.Eur. J. Med. Chem., 2021, 221, 113526. Hou X, Sun J-P, Ge L, Liang X, Li K, Zhang Y, Fang H*. Inhibition of Striatal-enriched Protein Tyrosine Phosphatase by Targeting Computationally Revealed Cryptic Pockets. Eur. J. Med. Chem.,2020, 190, 112131. Liu L, Liu R, Yang X, Hou X*, Fang H*. Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. Eur. J. Med. Chem.，2020, 191, 112142. Liang T, Hou X, Zhou Y, Yang X, Fang H*. Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors. ACS Med. Chem. Lett. 2019, 10, 1122-1127 Chen C, Yang X, Fang H*, Hou X*. Design, synthesis and preliminary bioactivity evaluations of 8-hydroxyquinoline derivatives as matrix metalloproteinase (MMP) inhibitors. Eur. J. Med. Chem., 2020, 181, 111563. Liu R, Liu L, Yang X, Fang H*. Discovery and development of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as Bcl-2/Mcl-1 inhibitors. Bioorg. Chem. 2019, 88, 102938. Hou X, Rooklin D, Yang D, Liang X, Li K, Lu J, Wang C, Xiao P, Zhang Y, Sun J, Fang H*. Computational Strategy for Bound State Structure Prediction in Structure-Based Virtual Screening: A Case Study of Protein Tyrosine Phosphatase Receptor Type O Inhibitor. J. Chem. Inf. Model., 2018, 58, 2331-2342.（封面论文) Xu Y, Yang X, Fang H*. Additive-and Photocatalyst-Free Borylation of Arylazo Sulfones under Visible Light. J. Org. Chem., 2018, 83, 12831-12837. Chen C, Hou X, Wang G, Pan W, Yang X, Zhang Y, Fang H*. Design, synthesis and biological evaluation of quinoline derivatives as HDAC class I inhibitors. Eur. J. Med. Chem., 2017, 133, 11-23. Hou X, Li R, Li K, Yu X, Sun J, Fang H*. Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening. J. Med. Chem. 2014, 57, 9309-9322.