个人简介
教育背景
2008-09--2011-06 中国科学院上海药物研究所 博士
2004-09--2007-03 同济大学 硕士
2000-09--2004-07 同济大学 学士
工作经历
2016-03~现在, 中国科学院上海药物研究所, 研究员
2013-04~2016-03,美国密歇根大学, 博士后
2011-06~2013-03,美国普渡大学, 博士后
2008-09~2011-06,中国科学院上海药物研究所, 博士
2007-04~2008-08,和记黄埔医药（上海）有限公司, 助理研究员
2004-09~2007-03,同济大学, 硕士
2000-09~2004-07,同济大学, 学士
近期论文
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Cyclization strategy leads to highly potent Bromodomain and extra-terminal (BET) Bromodomain inhibitors for the treatment of acute liver injury, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 通讯作者
Discovery of Highly Potent and Selective Thyroid Hormone Receptor β Agonists for the Treatment of Nonalcoholic Steatohepatitis, Journal of Medicinal Chemistry, 2023, 通讯作者
Rh(III)-catalyzed twofold unsymmetrical C-H alkenylation-annulation/amidation reaction enabled delivery of diverse furoquinazolinones, TETRAHEDRON LETTERS, 2022, 通讯作者
Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 通讯作者
Discovery of a Potent and Selective Degrader for USP7, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 通讯作者
Rhodium(III)-Catalyzed Asymmetric 1,2-Carboamidation of Alkenes Enables Access to Chiral 2,3-Dihydro-3-benzofuranmethanamides, ORGANIC LETTERS, 2022, 通讯作者
Discovery of novel Thieno2,3-dimidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 通讯作者
Celastrol recruits UBE3A to recognize and degrade the DNA binding domain of steroid receptors, ONCOGENE, 2022, 通讯作者
The p300 Inhibitor A-485 Exerts Antitumor Activity in Growth Hormone Pituitary Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2022, 通讯作者
A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6, ACTA PHARMACEUTICA SINICA B, 2022, 通讯作者
Rh(III)-catalyzed selective C7-H functionalization of indolines with 1,3-enynes enables access to six-membered 1,7-fused indolines, TETRAHEDRON LETTERS, 2021, 通讯作者
Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 通讯作者
Rhodium-Catalyzed Twofold Unsymmetrical C-H Alkenylation-Annulation/Thiolation Reaction To Access Thiobenzofurans, ORGANIC LETTERS, 2021, 通讯作者
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 通讯作者
Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 通讯作者
Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3, Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3, ACTA PHARMACEUTICA SINICA B, 2021, 通讯作者
Discovery of 8-Methyl-pyrrolo1,2-apyrazin-1(2H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, 2020, 通讯作者
Rh(iii)-catalyzed tandem annulative redox-neutral arylation/amidation of aromatic tethered alkenes, CHEMICAL SCIENCE, 2020, 通讯作者
RUTHENIUM(II)-CATALYZED REGIOSELECTIVE C-H HYDROXYMETHYLATION OF N-ARYL-AZAINDOLES WITH PARAFORMALDEHYDE, HETEROCYCLES, 2020, 通讯作者
Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 通讯作者
Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain, BIOORGANIC CHEMISTRY, 2020, 通讯作者
Ruthenium(II)-Catalyzed Regioselective Ortho C-H Allenylation of Electron-Rich Aniline and Phenol Derivatives, JOURNAL OF ORGANIC CHEMISTRY, 2020, 通讯作者
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, 2020, 通讯作者
Ru(II)-catalyzed regioselective C-7 hydroxymethylation of indolines with formaldehyde, TETRAHEDRON LETTERS, 2019, 通讯作者
Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 通讯作者
p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization, THERANOSTICS, 2019, 第 9 作者
Rh(III)-catalyzed Redox-Neutral Unsymmetrical C-H Alkylation and Amidation Reactions of N-Phenoxyacetamides, J. Am. Chem. Soc, 2018,
Rh(III)-Catalyzed C-H Functionalization of Indoles with Diazo Compounds: Facile Synthesis of Structurally Diverse 2,3-Fused Indoles, Adv. Synth. Catal., 2018, 通讯作者
Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor, JOURNAL OF MEDICINAL CHEMISTRY, 2018, 第 2 作者
Rh(III)-Catalyzed Redox-Neutral Unsymmetrical C-H Alkylation and Amidation Reactions of &ITN&IT-Phenoxyacetamides, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 通讯作者
Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression, JOURNALOFMEDICINALCHEMISTRY, 2018, 第 3 作者
Rhodium-Catalyzed C-H Functionalization of Indoles with Diazo Compounds: Synthesis of Structurally Diverse 2,3-Fused Indoles, ADVANCEDSYNTHESISCATALYSIS, 2018, 通讯作者
A Rh(III)-catalyzed redox-neutral C-H alkylation reaction with allylic alcohols by using a traceless oxidizing directing group, ORGANIC CHEMISTRY FRONTIERS, 2018, 通讯作者
Discovery of 1,8-acridinedione derivatives as novel GCN5 inhibitors via high throughput screening, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 通讯作者
Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 通讯作者
High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein Protein Interaction, JOURNAL OF MEDICINAL CHEMISTRY, 2018, 第 3 作者
Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression, JOURNAL OF MEDICINAL CHEMISTRY, 2018, 第 1 作者
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