唐淳 - 北京大学 - 化学与分子工程学院

个人简介

唐淳于1998毕业于浙江大学生物系。1998至2003年在美国马里兰大学霍华德休斯研究员Michael Summers院士的指导下，开展了对于逆转录病毒的蛋白和RNA的溶液结构的研究，获得生物化学博士学位。2003至2008年在美国国立卫生中心（NIH）糖尿病肾病和消化病研究所（NIDDK）的物理化学实验室（LCP）的G. Marius Clore院士实验室开展了博士后研究，开展了核磁共振（NMR）的方法学研究。2008-2010年在美国密苏里大学生物化学系任助理教授。2010年回国任中科院武汉物理与数学研究所研究员，并担任中科院生物磁共振重点实验室主任。2020年加入北京大学化学学院物理化学系，并加入生命科学联合中心。 Personal Information 2020 -- : Boya Professor, College of Chemistry and Molecular Engineering, Peking University 2020 -- : Senior Investigator, PKU-Tsinghua Center for Life Sciences 2010 -- : Principal Investigator, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences 2008 -- 2010: Assistant Professor, Department of Biochemistry, University of Missouri, Columbia 2003 -- 2008: Postdoc, Laboratory of Chemical Physics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health 2003: Ph.D. degree in Biochemistry, University of Maryland, Baltimore County 1998: B.S. degree in Biology, Zhejiang University

研究领域

Method development of biomolecular NMR Method development for integrative structure refinement, for better use of small angle scattering, single-molecular FRET, and chemical crosslinking data To understand how post-translational/transcriptional modifications and environmental factors impact the structure and dynamics of proteins and RNAs

近期论文

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Ma YX, Li HZ, Gong Z, Yang S, Wang P and Tang C. (2022) Nucleobase Clustering Contributes to the Formation and Hollowing of Repeat-Expansion RNA Condensate. J. Am. Chem. Soc, doi.org/10.1021/jacs.1c12085 Dong X, Qin LY, Gong Z, Qin S, Zhou HX and Tang C. (2022) Preferential Interactions of a Crowder Protein with the Specific Binding Site of a Native Protein Complex. J Phys Chem Lett, doi.org/10.1021/acs.jpclett.1c03794 Czaplewski C, Gong Z, Lubecka EA, Xue K, Tang C, Liwo A. (2021) Recent Developments in Data-Assisted Modeling of Flexible Proteins. Front. Mol. Biosci, doi.org/10.3389/fmolb.2021.765562 Fu WT, Zhang MK, Liao JN, Tang Q, Lei YX, Gong Z, Shan LH, Duan MJ, Chai X, Pang JP, Tang C, Wang XW, Xu XH, Li D, Sheng R, Hou TJ. (2021) Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers. J. Med. Chem, doi.org/10.1021/acs.jmedchem.1c01287 Kogut M, Gong Z, Tang C, Liwo A. （2021）Pseudopotentials for coarse-grained cross-link-assisted modeling of protein structures. J Comput Chem，42 (29) : 2054-2067 Qin LY, Gong Z, Liu K, Dong X and Tang C. （2021）Kinetic Constraints in the Specific Interaction between Phosphorylated Ubiquitin and Proteasomal Shuttle Factors. Biomolecules，10.3390 / biom11071008 Lerner E, Barth A, Hendrix J, Ambrose B, Birkedal V, Blanchard SC, Börner R, Chung HS, Cordes T, Craggs TD, Deniz AA, Diao JJ, Fei JY, Gonzalez RL, Gopich IV, Ha T, Hanke CA, Haran G, Hatzakis NS, Hohng SC, Hong SC, Hugel T, Ingargiola A, Joo C, Kapanidis AN, Kim HD, Laurence T, Lee NK, Lee TH, Lemke EA, Margeat E, Michaelis J, Michalet X, Myong S, Nettels D, Peulen TO, Ploetz E, Razvag Y, Robb NC, Schuler B, Soleimaninejad H, Tang C, Vafabakhsh R, Lamb DC, Seidel CA, Weiss S. （2021） FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices. eLife, 2021；10：e60416 Gong Z, Ye SX and Tang C. (2020) Tightening the Crosslinking Distance Restraints for Better Resolution of Protein Structure and Dynamics. Structure, 28:1160-1167 Yang J, Gong Z, Lu YB, Xu CJ, Wei TF, Yang MS, Zhan TW, Yang YH, Lin L, Liu JF, Tang C and Zhang WP. (2020) FLIM–FRET-Based Structural Characterization of a Class-A GPCR Dimer in the Cell Membrane. J Mol Biol，432：4596-4611 Gong Z, Yang S, Dong X, Yang QF, Zhu YL, Xiao Y, Tang C. （2020）Hierarchical Conformational Dynamics Confers Thermal Adaptability to preQ1 RNA Riboswitches. J Mol Biol , 4 32:4523-4543 Gong Z, Ye SX, Nie ZF and Tang C. (2020) The Conformational Preference of Chemical Cross-linkers Determines the Cross-linking Probability of Reactive Protein Residues. J Phy Chem B , 123:4446-4453 Tang C , Gong Z. (2020) Integrating Non-NMR Distance Restraints to Augment NMR Depiction of Protein Structure and Dynamics. J Mol Biol，432:2913-2929 Tang C and Zhang wp. (2020) How Phosphorylation by PINK1 Remodels the Ubiquitin System: A Perspective from Structure and Dynamics. Biochemistry, 59:26-33 You ZY, Jiang WX, Qin LY, Gong Z, Wan W, Li J, Wang YS, Zhang HT, Peng C, Zhou TH, Tang C and Liu W. (2019) Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress. Nat Commun,10:5792 Gong Z, Yang S, Yang QF, Zhu YL, Jiang J and Tang C. (2019) Refining RNA solution structures with the integrative use of label-free paramagnetic relaxation enhancement NMR. Biophys. Rep, 5:244-253 Ye SX, Gong Z, Yang J, An YX, Liu Z, Zhao Q, Lescop E, Dong X, Tang C. (2019) Ubiquitin is double-phosphorylated by PINK1 for enhanced pH-sensitivity of conformational switch. Protein & Cell, 10:908-913 Yang QF, Tang C. (2019) On the necessity of an integrative approach to understand protein structural dynamics. J Zhejiang Univ Sci B, 20(6):496-502 Liu Z, Dong X, Yi HW, Yang J, Gong Z, Wang Y, Liu K, Zhang WP, Tang C. (2019) Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13. Cell Discov, 5:19 冉梦琳, 覃凌云, 唐淳, 董旭. (2019) 磷酸化调控泛素单体与Rad23A/Ubiquilin-1中泛素结合域互作的检测. 波谱学杂志, 36(01):15-22 Huang JB, Dong X, Gong Z, Qin LY, Yang S, Zhu YL, Wang X, Zhang DL, Zou TT, Yin P and Tang C. (2019) Solution structure of the RNA recgonition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein & Cell, 10:272-284 Yang QF, Tang C. (2019) On the necessity of an integrative approach to understand protein structural dynamics. J ZHEJIANG UNIV-SC B, 20:496–502 杨菊, 龚州, 吴明, 魏尔清, 卢韵碧, 唐淳, 张纬萍. (2018) GPR17同源二聚体结构与功能的研究. 中国药理学与毒理学杂志, 32(09):739 Gong Z, Charles DS and Tang C. (2018) Theory and practice of using solvent paramagnetic relaxtion enhancement to characterize protein conformational dynamics. Methods, 148:48-56 Zhang XY, Wang JH, Tan D, Li Q, Li MD, Gong Z, Tang C, Liu ZL, Dong MQ, Lei XG. (2018). Carboxylate-selective chemical cross-linkers for mass spectrometric analysis of protein structures. Anal Chem, 90: 1195-1201 Liu Z, Gong Z, Cao Y, Ding YH, Dong MQ, Lu YB, Zhang WP, Tang C. (2018). Characterizing Protein Dynamics with Integrative Use of Bulk and Single-Molecule Techniques. Biochemistry, 57:305-313