个人简介

1969年出生，现任中国科学院成都有机化学研究所（成都有机化学有限公司）研究员，博士生导师。1990年毕业于云南大学化学系。2001年毕业于中国科学院成都有机化学研究所有机化学专业，获理学博士学位。2001年8月至2003年2月在香港大学化学系作博士后研究工作，主要从事重氮化合物的催化不对称碳氢插入反应的研究。2003年8月至2005年1月在德国 Osnabrueck 大学化学研究所生物有机实验室从事核酸化学研究工作。2005年回国，在中国科学院成都有机化学研究所（成都有机化学有限公司）工作，2008年被评为研究员、博士导师

研究领域

不对称催化反应的研究，藉此合成一些重要的手性化合物，并应用于手性药物及其关键中间体的合成。近年来在手性路易斯碱催化的酮亚胺、α-亚胺基酯、β-烯胺基酯以及γ-亚胺基酯的不对称氢化硅烷化反应的研究中取得了一定的成果，从而发展了一种条件温和、不使用金属催化剂、经济环保的不对称催化方法，高活性、高选择性地合成手性胺、手性非天然α-氨基酸衍生物、手性β-氨基酸衍生物以及手性γ-氨基酸衍生物等

主要研究兴趣为不对称催化反应的研究，藉此合成一些重要的手性化合物，并应用于手性药物及其关键中间体的合成。

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Ji-YuiWang, Qing Zhang, Hui Zhang, Yu-Jun Feng, Wei-Cheng Yuan, Xiao-Mei Zhang*: “Organocatalytic enantioselective Michael addition of a kojic acid derivative to nitro olefins” Org. Biomol. Chem. 2012, 10, 2950-2954. 2. Zhou-Yang Xue, Li-Xin Liu, Yan Jiang, Wei-Cheng Yuan, and Xiao-Mei Zhang*: “Highly Enantioselective Lewis Base Organocatalyzed Hydrosilylation of γ-Imino Esters” Eur. J. Org. Chem. 2012, 251–255. 3. Yan Jiang, Li-Xin Liu, Wei-Cheng Yuan, Xiao-Mei Zhang*: “Lewis Bae Organocatalyzed Enantioselective Hydrosilylation of 1,4-Benzoxazines” Synlett 2012, 23, 1797–1800. 4. Hui Zhang, Chun-Xia Lian, Wei-Cheng Yuan, Xiao-Mei Zhang*: “lAddition of Purines to N-Boc Imines Generated in Situ in Water: Efficient Synthesis of Novel Acyclic Purine Azanucleosides” Synlett 2012, 23, 1339–1342. 5. Ji-YuiWang, Hui Zhang, Yu-Hua Liao, Wei-Cheng Yuan, Yu-Jun Feng,* Xiao-Mei Zhang*: “Organocatalytic Synthesis of Enantioenriched β-Aryl-splitomicins” Synlett 2012, 23, 796–800. 6. Yan Jiang, Xing Chen, Yongsheng Zheng, Zhouyang Xue, Chang Shu, Weicheng Yuan and Xiaomei Zhang*: “Highly Diastereoselective and Enantioselective Synthesis of α-hydroxy-β-Amino Acid Derivatives by the Lewis Base Organocatalyzed Hydrosilylation of α-acetoxy-β-Enamino Esters” Angew. Chem. Int. Ed. 2011, 50, 7304-7307. 7. Xing Chen, Yongsheng Zheng, Chang Shu, Weicheng Yuan, Bo Liu, and Xiaomei Zhang*: “Enantioselective Synthesis of 4-Substituted 4,5-Dihydro- 1H-[1,5]benzodiazepine-2(3H)- ones by the Lewis Base-Catalyzed Hydrosilylation” J. Org. Chem. 2011, 76, 9109-9115. 8. Zhou-Yang Xue, Yan Jiang, Xiao-Zhi Peng, Wei-Cheng Yuan, Xiao-Mei Zhang*: “The First General, Highly Enantioselective Lewis Base Organocatalyzed Hydrosilylation of Benzoxazinones and Quinoxalinones.” Adv. Synth. Catal. 2010, 352, 2132 – 2136. 9. Hui Zhang, Yu-Hua Liao, Wei-Cheng Yuan, Xiao-Mei Zhang*: “Organocatalytic Enantioselective Friedel–Crafts Alkylation of Sesamol with Nitro Olefins.” Eur. J. Org. Chem. 2010, 3215-3218. 10. Zhou-Yang Xue, Yan Jiang, Wei-Cheng Yuan, Xiao-Mei Zhang*: “The First Highly Enantioselective Lewis Base Organocatalyzed Hydrosilylation of α-Imino Esters.” Eur. J. Org. Chem. 2010, 616-619. 11. Hui Zhang, Ming-Gui Chen, Chun-Xia Lian, Wei-Cheng Yuan, Xiao-Mei Zhang*: “Remarkably Mild and Efficient Cetrimonium Bromide Catalyzed Friedel–Crafts Amidoalkylation of Sesamols with N-Boc Imines Generated In Situ in Aqueous Medium.” Synlett 2010, 1415-1417. 12. Hong-Jie Zheng, Wen-Bing Chen, Zhi-Jun Wu, Jin-Gen Deng, Wen-Qing Lin, Wei-Cheng Yuan, Xiao-Mei Zhang*: “Highly Enantioselective Synthesis of β-Amino Acid Derivatives by the Lewis Base Catalyzed Hydrosilylation of β-Enamino Esters.” Chem. Eur. J. 2008, 14, 9864-9867. 13. Meng-Xia Xue, Xiao-Mei Zhang*, Liu-Zhu Gong: “The First Organocatalytic Enatio- and Diastereoselective 1,3-Dipolar Cycloaddition of Azomethine Ylides with Nitroalkenes.” Synlett 2008, 691-694. 14. Hongjie Zheng, Jingen Deng, Wenqing Lin, Xiaomei Zhang*: “Enantioselective hydrosilylation of ketimines with trichlorosilane promoted by chiral N-picolinoylaminoalcohols.” Tetrahedron Lett. 2007, 48, 7934-7937. 15. Gexin Yan, Yong Wu, Wenqing Lin, Xiao-Mei Zhang*: “Synthesis of novel chiral oxazoline ligands and application in the highly enantioselective diethylzinc addition to N-diphenylphosphinoyl-imines.” Tetrahedron: Asymmetry 2007, 18, 2643-2648.