个人简介

Ph.D., Harvard University, 1970

研究领域

Organic Chemistry Medicinal Chemistry Chemical Biology Bioorganic Chemistry Biochemistry

Organic and Bioorganic Chemistry Our research group has interests in the areas of mechanistic, synthetic and bio-organic chemistry. Most of our research has centered on free radical chemistry. Areas of interest to us include: the mechanisms of the free radical reactions of natural products, such as lipids and phospholipids with molecular oxygen (a process important in the degradation of fats and oils and implicated in vivo); mechanisms and utility of free radical reactions; and the control of chemical and biological processes by means of light.

近期论文

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Xu L, Porter NA. Reactivities and Products of Free Radical Oxidation of Cholestadienols. Journal of The American Chemical Society. 2014, 0(0): 0.[Epub ahead of print] Codreanu SG, Ullery JC, Zhu J, Tallman KA, Beavers WN, Porter NA, Marnett LJ, Zhang B, Liebler DC. Alkylation Damage by Lipid Electrophile Targets functional Protein Systems. Molecular & Cellular. 2014, 0(0): 0.[Epub ahead of print] Liu W, Xu L, Lamberson C, Haas D, Korade Z, Porter NA. A Highly Sensitive Method for Analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz Syndrome. The Journal of Lipid Research. 2014, 55(2): 329-337. Lamberson CR, Xu L, Muchalski H, Montenegro-Burke JR, Shmanai VV, Bekish AV, McLean JA, Clarke CF, Shchepinov MS, Porter NA. Unusual Kinetic Isotope Effects of Deuterium Reinforced Polyunsaturated Fatty Acids in Tocopherol-Mediated Free Radical Chain Oxidations. Journal of The American Chemical Society. 2014, 136(3): 838-841. Korade Z, Xu L, Harrison FE, Ahsen R, Hart SE,Folkes OM, Mirnics K, Porter NA. Antioxidant Supplementation Ameliorates Molecular Deficits in Smith-Lemli-Opitz Syndrome. Biological Psychiatry. 2014, 75(3): 215-222. Shchepin RV, Liu W, Yin H, Zagol-Ikapitte I, Amin T, Jeong BS, Roberts LJ 2nd, Oates JA, Porter NA, Boutaud O. Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues. ACS Medicinal Chemistry Letters. 2013, 4(8): 710-714. Windsor K, Genaro-Mattos TC, Kim HY, Liu W, Tallman KA, Miyamoto S, Korade Z, Porter NA. Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome. The Journal of Lipid Research. 2013, 54(10): 2842-2850. Korade Z, Xu L, Mirnics K, Porter NA. Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome. Journal of Inherited Metabolic Disease. 2013, 36(1): 113-122. Liu W, Xu L, Lamberson CR, Merkens LS, Steiner RD, Elias ER, Haas D, Porter NA. Assays of Plasma Dehydrocholesteryl esters and Oxysterols from Smith-Lemli-Opitz syndrome patients. Journal of Lipid Research. 2013, 54(1): 244-253. Tallman KA, Armstrong MD, Milne SB, Marnett LJ, Brown HA, Porter NA. Cobalt Carbonyl Complexes as Probes for Alkyne-Tagged Lipids. Journal of Lipid Research. 2013, 54(3): 859-868. Xu L, Korade Z, Rosado DA Jr, Mirnics K, Porter NA. Metabolism of oxysterols derived from non-enzymatic oxidation of 7-dehydrocholesterol in cells. Journal of Lipid Research. 2013, (36): 1135-1143. Porter NA. A Perspective on Free Radical Autoxidation: The Physical Organic Chemistry of Polyunsaturated Fatty Acid and Sterol Peroxidation. Journal of Organic Chemistry. 2013, (78): 3511-3524. Xu LB, Sheflin LG, Porter NA, Fliesler SJ. 7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. Biochimica ET Biophysica Acta-Molecular And Cell Biology of Lipids. 2012, 1821 (6): 877-883. Hill S, Lamberson CR, Xu LB, To R, Tsui HS, Shmanai VV, Bekish AV, Awad AM, Marbois BN, Cantor CR, Porter NA, Clarke CF, Shchepinov MS. Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation. Free Radical Biology And Medicine. 2012, 53 (4): 893-906. Moller MN, Hatch DM, Kim HYH, Porter NA. Superoxide Reaction with Tyrosyl Radicals Generates para-Hydroperoxy and para-Hydroxy Derivatives of Tyrosine. Journal of the American Chemical Society. 2012, 134 (40): 16773-16780. Xu LB, Sheflin LG, Porter NA, Fliesler SJ. 7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. Biochimica ET Biophysica Acta-Molecular And Cell Biology of Lipids. 2012, 1821 (6): 877-883. Yang JH, Chaurand P, Norris JL, Porter NA, Caprioli RM. Activity-Based Probes Linked with Laser-Cleavable Mass Tags for Signal Amplification in Imaging Mass Spectrometry: Analysis of Serine Hydrolase Enzymes in Mammalian Tissue. Analytical Chemistry. 2012, 84 (8): 3689-3695. Xu LB, Mirnics K, Bowman AB, Liu W, Da J, Porter NA, Korade Z. DHCEO accumulation is a critical mediator of pathophysiology in a Smith-Lemli-Opitz syndrome model. Neurobiology of Disease. 2012, 45 (3): 923-929. Yin HY, Xu LB, Porter NA. Free Radical Lipid Peroxidation: Mechanisms and Analysis. Chemical Reviews. 2011, 111 (10): 5944-5972. Xu LB, Liu W, Sheflin LG, Fliesler SJ, Porter NA. Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome. Journal of Lipid Research. 2011, 52 (10): 1810-1820. McGrath CE, Tallman KA, Porter NA Marnett LJ. Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome. Chemical Research in Toxicology. 2011, 24, 357-70. Liu W, Porter NA, Schneider C, Brash AR, and Yin H. Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition. Free Radical Biology Medical. 2011, 50, 166-78. 10.1016/j.freeradbiomed. 2010.10.709 Nam TG, Ku JM, Park HG, Porter NA and Jeong BS. New synthetic route to N-tocopherol derivatives: Synthesis of pyrrolopyridinol analogue of α-tocopherol from pyridoxine. Organic & Biomolecular Chemistry. 2011, 9, 1749-55.