Mchaourab, Hassane S. - Vanderbilt University

研究领域

Protein aggregation in aging and disease Multidrug resistance in cancer and infectious diseases Neurotransmitter transporters CamKII

近期论文

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Mishra S, Stein RA, McHaourab HS.Cataract-linked γD-crystallin mutants have weak affinity to lens chaperones α-crystallins.FEBS Lett. 2012 Feb 17;586(4):330-6. PMID:22289178. Hoffman L, Stein RA, Colbran RJ, Mchaourab HS. Conformational changes underlying calcium/calmodulin-dependent protein kinase II activation. EMBO J. 2011 Apr 6;30(7):1251-62. PMID: 21343908. Kazmier K, Alexander NS, Meiler J, Mchaourab HS. Algorithm for selection of optimized EPR distance restraints for de novo protein structure determination. J Struct Biol. 2011 Mar;173(3):549-57. PMID: 21074624. Hirst SJ, Alexander N, Mchaourab HS, Meiler J. RosettaEPR: an integrated tool for protein structure determination from sparse EPR data. J Struct Biol. 2011 Mar;173(3):506-14. PMID: 21029778 Claxton DP, Quick M, Shi L, de Carvalho FD, Weinstein H, Javitch JA, Mchaourab HS. Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters. Nat Struct Mol Biol. 2010 Jun 20. PMID: 20562855 Amadi ST, Koteiche HA, Mishra S, Mchaourab HS. Structure, dynamics and substrate-induced conformational changes of the multidrug transporter EmrE in liposomes. J Biol Chem. 2010 Jun 15. PMID: 20551331 Zou P, Mchaourab HS. Increased sensitivity and extended range of distance measurements in spin-labeled membrane proteins: Q-band double electron-electron resonance and nanoscale bilayers. Biophys J. 2010 Mar 17;98(6):L18-20. PMID: 20303847 Gustot A, Smriti, Ruysschaert JM, Mchaourab HS, Govaerts C. Lipid composition regulates the orientation of transmembrane helices in HorA, an ABC multidrug transporter. J Biol Chem. 2010 May 7;285(19):14144-51. PMID: 20223819 Zou P, Mchaourab HS. Alternating access of the putative substrate-binding chamber in the ABC transporter MsbA. J Mol Biol. 2009 Oct 30;393(3):574-85. PMID: 19715704 Zou P, Bortolus M, Mchaourab HS. Conformational cycle of the ABC transporter MsbA in liposomes: detailed analysis using double electron-electron resonance spectroscopy.J Mol Biol. 2009 Oct 30;393(3):586-97. PMID: 19715702 Mchaourab HS, Godar JA, Stewart P.Structure and mechanism of protein stability sensors: The chaperone activity of small heat-shock proteins. Biochemistry. 2009 Mar 26. Smriti, Zou P, Mchaourab HS.Mapping daunorubicin binding sites in the ABC transporter MsbA using site-specific quenching by spin labels. J Biol Chem. 2009 Mar 11. Latham JC, Stein RA, Bornhop DJ, Mchaourab HS. Free-Solution Label-Free Detection of alpha-Crystallin Chaperone Interactions by Back-Scattering Interferometry. Anal Chem. 2009 Jan 29. Kumar MS, Koteiche HA, Claxton DP, Mchaourab HS.Disulfide cross-links in the interaction of a cataract-linked alphaA-crystallin mutant with betaB1-crystallin. FEBS Lett. 2009 Jan 5;583(1):175-9. Mchaourab HS, Mishra S, Koteiche HA, Amadi SH.Role of sequence bias in the topology of the multidrug transporter EmrE. Biochemistry. 2008 Aug 5;47(31):7980-2. Alexander N, Al-Mestarihi A, Bortolus M, McHaourab H, Meiler J. De Novo High-Resolution Protein Structure Determination from Sparse Spin-Labeling EPR Data. Structure. 2008 Feb;16(2):181-95. PMID: 18275810 Claxton DP, Zou P, Mchaourab HS. Structure and orientation of T4 lysozyme bound to the small heat shock protein alpha-crystallin. J Mol Biol. 2008 Jan 25;375(4):1026-39. PMID: 18062989 Cobb NJ, Sönnichsen FD, Mchaourab HS, Surewicz WK. Molecular architecture of human prion protein amyloid: A parallel, in-register -structure. PNAS. November 19, 2007. PMID: 18025469 Borbat PP, Surendhran K, Bortolus M, Zou P, Freed JH, Mchaourab HS. Conformational Motion of the ABC Transporter MsbA Induced by ATP Hydrolysis. PLoS Biol. 2007 Oct 9;5(10):e271. PMID: 17927448 Mchaourab HS, Kumar MS, Koteiche HA. Specificity of alphaA-crystallin binding to destabilized mutants of betaB1-crystallin. FEBS Lett. 2007 May 15;581(10):1939-43. Epub 2007 Apr 13.PMID: 17449033 Koteiche HA, Kumar MS, Mchaourab HS. Analysis of betaB1-crystallin unfolding equilibrium by spin and fluorescence labeling: evidence of a dimeric intermediate. FEBS Lett. 2007 May 15;581(10):1933-8. Epub 2007 Apr 12.PMID: 17448466 Mori T, Williams DR, Byrne MO, Qin X, Egli M, Mchaourab HS, Stewart PL, Johnson CH. Elucidating the ticking of an in vitro circadian clockwork. PLoS Biol. 2007 Apr;5(4):e93. PMID: 17388688 Zou P, Surendhran K, Mchaourab HS. Distance measurements by fluorescence energy homotransfer: evaluation in T4 lysozyme and correlation with dipolar coupling between spin labels. Biophys J. 2007 Feb 15;92(4):L27-9. Epub 2006 Dec 1. PMID: 17142264 Shi J, Koteiche HA, Mchaourab HS, Stewart PL. Cryoelectron microscopy and EPR analysis of engineered symmetric and polydisperse Hsp16.5 assemblies reveals determinants of polydispersity and substrate binding. J Biol Chem. 2006 Dec 29;281(52):40420-8. Epub 2006 Oct 31. PMID: 17079234 Koteiche HA, Mchaourab HS. Mechanism of a hereditary cataract phenotype. Mutations in alphaA-crystallin activate substrate binding. J Biol Chem. 2006 May 19;281(20):14273-9. Epub 2006 Mar 12. PMID: 16531622 Koteiche HA, Chiu S, Majdoch RL, Stewart PL, Mchaourab HS. Atomic models by cryo-EM and site-directed spin labeling: application to the N-terminal region of Hsp16.5. Structure. 2005 Aug;13(8):1165-71. PMID: 16084388 Dong J, Yang G, Mchaourab HS. Structural basis of energy transduction in the transport cycle of MsbA. Science. 2005 May 13;308(5724):1023-8. Shashidharamurthy R, Koteiche HA, Dong J, Mchaourab HS. Mechanism of chaperone function in small heat shock proteins: dissociation of the HSP27 oligomer is required for recognition and binding of destabilized T4 lysozyme. J Biol Chem. 2005 Feb 18;280(7):5281-9. Epub 2004 Nov 12. PMID: 15542604 Sathish HA, Koteiche HA, Mchaourab HS. Binding of destabilized betaB2-crystallin mutants to alpha-crystallin: the role of a folding intermediate. J Biol Chem. 2004 Apr 16;279(16):16425-32. Epub 2004 Feb 3. PMID: 14761939 Sathish HA, Stein RA, Yang G, Mchaourab HS. Mechanism of chaperone function in small heat-shock proteins. Fluorescence studies of the conformations of T4 lysozyme bound to alphaB-crystallin. J Biol Chem. 2003 Nov 7;278(45):44214-21. Epub 2003 Aug 18. PMID: 12928430 Koteiche HA, Reeves MD, Mchaourab HS. Structure of the substrate binding pocket of the multidrug transporter EmrE: site-directed spin labeling of transmembrane segment 1. Biochemistry. 2003 May 27;42(20):6099-105. PMID: 12755611 Koteiche HA, Mchaourab HS. Mechanism of chaperone function in small heat-shock proteins. Phosphorylation-induced activation of two-mode binding in alphaB-crystallin. J Biol Chem. 2003 Mar 21;278(12):10361-7. Epub 2003 Jan 14. PMID: 12529319 Mchaourab HS, Dodson EK, Koteiche HA. Mechanism of chaperone function in small heat shock proteins. Two-mode binding of the excited states of T4 lysozyme mutants by alphaA-crystallin. J Biol Chem. 2002 Oct 25;277(43):40557-66. Epub 2002 Aug 19. PMID: 12189146 Koteiche HA, Mchaourab HS. The determinants of the oligomeric structure in Hsp16.5 are encoded in the alpha-crystallin domain. FEBS Lett. 2002 May 22;519(1-3):16-22. PMID: 12023011 Borbat PP, Mchaourab HS, Freed JH. Protein structure determination using long-distance constraints from double-quantum coherence ESR: study of T4 lysozyme. J Am Chem Soc. 2002 May 15;124(19):5304-14. PMID: 11996571 Mansoor SE, Mchaourab HS, Farrens DL. Mapping proximity within proteins using fluorescence spectroscopy. A study of T4 lysozyme showing that tryptophan residues quench bimane fluorescence. Biochemistry. 2002 Feb 26;41(8):2475-84. PMID: 11851393 Kaplan RS, Mayor JA, Kotaria R, Walters DE, Mchaourab HS. The yeast mitochondrial citrate transport protein: determination of secondary structure and solvent accessibility of transmembrane domain IV using site-directed spin labeling. Biochemistry. 2000 Aug 8;39(31):9157-63. PMID: 10924109 Haley DA, Bova MP, Huang QL, Mchaourab HS, Stewart PL. Small heat-shock protein structures reveal a continuum from symmetric to variable assemblies. J Mol Biol. 2000 Apr 28;298(2):261-72. PMID: 10764595 Bova MP, Mchaourab HS, Han Y, Fung BK. Subunit exchange of small heat shock proteins. Analysis of oligomer formation of alphaA-crystallin and Hsp27 by fluorescence resonance energy transfer and site-directed truncations. J Biol Chem. 2000 Jan 14;275(2):1035-42. PMID: 10625643 Koteiche HA, Mchaourab HS. Folding pattern of the alpha-crystallin domain in alphaA-crystallin determined by site-directed spin labeling. J Mol Biol. 1999 Nov 26;294(2):561-77. PMID: 10610780 Mansoor SE, Mchaourab HS, Farrens DL. Determination of protein secondary structure and solvent accessibility using site-directed fluorescence labeling. Studies of T4 lysozyme using the fluorescent probe monobromobimane. Biochemistry. 1999 Dec 7;38(49):16383-93. PMID: 10587464 Barnes JP, Liang Z, Mchaourab HS, Freed JH, Hubbell WL. A multifrequency electron spin resonance study of T4 lysozyme dynamics. Biophys J. 1999 Jun;76(6):3298-306. PMID: 10354455 Mchaourab HS, Kalai T, Hideg K, Hubbell WL. Motion of spin-labeled side chains in T4 lysozyme: effect of side chain structure. Biochemistry. 1999 Mar 9;38(10):2947-55. PMID: 10074347 Berengian AR, Parfenova M, Mchaourab HS. Site-directed spin labeling study of subunit interactions in the alpha-crystallin domain of small heat-shock proteins. Comparison of the oligomer symmetry in alphaA-crystallin, HSP 27, and HSP 16.3. J Biol Chem. 1999 Mar 5;274(10):6305-14. PMID: 10037719 Koteiche HA, Berengian AR, Mchaourab HS. Identification of protein folding patterns using site-directed spin labeling. Structural characterization of a beta-sheet and putative substrate binding regions in the conserved domain of alpha A-crystallin. Biochemistry. 1998 Sep 15;37(37):12681-8. PMID: 9737844 Mchaourab HS, Berengian AR, Koteiche HA. Site-directed spin-labeling study of the structure and subunit interactions along a conserved sequence in the alpha-crystallin domain of heat-shock protein 27. Evidence of a conserved subunit interface. Biochemistry. 1997 Dec 2;36(48):14627-34. PMID: 9398181 Berengian AR, Bova MP, Mchaourab HS. Structure and function of the conserved domain in alphaA-crystallin. Site-directed spin labeling identifies a beta-strand located near a subunit interface. Biochemistry. 1997 Aug 19;36(33):9951-7. PMID: 9296605 Mchaourab HS, Oh KJ, Fang CJ, Hubbell WL. Conformation of T4 lysozyme in solution. Hinge-bending motion and the substrate-induced conformational transition studied by site-directed spin labeling. Biochemistry. 1997 Jan 14;36(2):307-16. PMID: 9003182 Hubbell WL, Mchaourab HS, Altenbach C, Lietzow MA. Watching proteins move using site-directed spin labeling. Structure. 1996 Jul 15;4(7):779-83. PMID: 8805569 Mchaourab HS, Lietzow MA, Hideg K, Hubbell WL. Motion of spin-labeled side chains in T4 lysozyme. Correlation with protein structure and dynamics. Biochemistry. 1996 Jun 18;35(24):7692-704. PMID: 8672470 Singh RJ, Feix JB, Mchaourab HS, Hogg N, Kalyanaraman B. Spin-labeling study of the oxidative damage to low-density lipoprotein. Arch Biochem Biophys. 1995 Jun 20;320(1):155-61. PMID: 7793976 Singh RJ, Hogg N, Mchaourab HS, Kalyanaraman B. Physical and chemical interactions between nitric oxide and nitroxides. Biochim Biophys Acta. 1994 Dec 15;1201(3):437-41. PMID: 7803474 Mchaourab HS, Hyde JS, Feix JB. Binding and state of aggregation of spin-labeled cecropin AD in phospholipid bilayers: effects of surface charge and fatty acyl chain length. Biochemistry. 1994 May 31;33(21):6691-9. PMID: 8204604 Mchaourab HS, Hyde JS, Feix JB. Aggregation state of spin-labeled cecropin AD in solution. Biochemistry. 1993 Nov 9;32(44):11895-902. PMID: 7692965 Mchaourab HS, Pfenninger S, Antholine WE, Felix CC, Hyde JS, Kroneck PM. Multiquantum EPR of the mixed valence copper site in nitrous oxide reductase. Biophys J. 1993 May;64(5):1576-9. PMID: 8391869