李晓波 - 中国科学院新疆理化技术研究所 -

研究领域

化学 1．化学遗传学方法筛选抗肿瘤先导化合物及抗肿瘤分子机理研究化学遗传学(chemical genetics)是一门应用小分子有机化合物来系统地干扰和探索细胞内生物学过程，从而鉴定参与这些生物过程的生物大分子的方法。对新疆特有植物中提取组分，化合物及有机合成的化合物体外进行高通量筛选，获得高活性的抗肿瘤组分、化合物。结合流式细胞技术，基因芯片，蛋白芯片技术研究化合物在细胞内的生物靶点及对细胞凋亡，细胞周期相关的信号转导途径的影响。 2. 植物次生代谢研究及棉花纤维发育分子机理研究棉花（彩棉）纤维品质主要取决于其纤维沉积特性及微观结构，而它们均受到纤维素合成及次生代谢合成的影响。该研究组利用关联分析、图位克隆以及转基因等方法对彩棉色素合成途径及次生代谢途径中的重要基因功能的系统深入研究，阐明影响彩色棉花纤维品质的分子调控网络。此项研究将有助于培育多色彩、高品质的新品种。

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Li xiaobo, Lu xueying，Xiao xiangwen, Haji Akber Aisa. Anti-proliferative and inhibits expression of VEGF and angiogenesis effects of luteolin in human gastric cancer BGC-823 cell line[J].Mol Pharmacol.(submitted) Xueling Hou, Xiaobo Li, Helimay Hemit, Haji Akber Aisa. Synthesis, characterization and antitumor activities of new palladium (II) complexes with 1-(alkyldithiocarbonyl)-imidazoles. (under viewing) Li xiaobo, Lu xueying，liyanhong. Characterize on gene express chip of luteolin inhibiting gastric cancer. (under viewing) Li xiaobo, Li yanhong, Lu xueying, Dithiocarbamate as anticancer agent: relationship of structure and bioactivities. (under viewing) Li xiaobo, Liang guohua, Zhu lihuang et al. Functional analysis of a semi-dwarf sdg in rice with near isogenic lines. (In English) Progress in natural science. 2004, Vol.14, No.7: 38-43. Li xiaobo, Xu jichen and Zhu lihuang. Gibberellins signaling transduction and plant dwarfism. Journal of Chinese biotechnology. 2004, Vol.24, No.12: 26-31. Xu jichen, Li xiaobo, Zhu lihuang. Comparative mapping of rice root traits in seedlings grown in nutrient or non-nutrient solution. (In English) Progress in natural science. 2004, Vol.14, No.4: 327-331. Xu jichen, Liu guozheng, Li xiazheng, Xiao han, Li xiaobo, Li hongchang, Wei lirong, Zhu lihuang. Characterization and electronic hybridization of a gene encoding UROD in rice. Progress in natural science. 2004, Vol 14, No.1: 64-69. Li hongchang, Qian qian, Wang yun, Li xiaobo, Zhu lihuang, Xu jichen. Characterization and mapping of a white panicle mutant gene in rice. Chinese Science Bulletin, 2003, Vol 48. No.5: 457-459. Li xiaobo and Li zhiping. Separation and analysis of interface-active substances in Karalay crude oil. Oilfield Chemistry. 1999,Vol16,No.4: 333-335.