个人简介

Ph.D., Johns Hopkins University, 2000

研究领域

Synthetic Biology Organic Chemistry Natural Products Mechanistic Enzymology Chemical Biology Biosynthesis Biochemistry

The primary mission of the Bachmann Lab is to apply knowledge of the design rules for secondary metabolism at the chemical, biochemical and genetic levels toward the biosynthesis of "non-natural" compounds of high value to biomedical research and the clinic. Key to this program in "synthetic biology" is the dissection of the mechanisms by which life makes bioactive molecules in vivo. The lab is organized according to three interlocking research areas: Biosynthesis, Synthetic Biology, and Discovery. These subgroups each have basic research and applied components and overlap with one another both thematically and methodologically.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Bachmann, B. O., Van Lanen, S. G., Baltz, R. H. Microbial genome mining for accelerated natural products discovery: is a renaissance in the making? Journal of Industrial Microbiology & Biotechnology. 2014, 41 (2): 175-184. Tourtas, T., Schlomberg, J., Wessel, J. M., Bachmann, B. O., Schlotzer-Schrehardt, U., Kruse, F. E. Graft Adhesion in Descemet Membrane Endothelial Keratoplasty Dependent on Size of Removal of Host's Descemet Membrane. Jama Opthalmology. 2014, 132 (2): 155-161 . Birmingham, W. R., Starbird, C. A., Panosian, T. D., Nannemann, D. P., Iverson, T. M., Bachmann, B. O. Bioretrosynthetic construction of a didanosine biosynthetic pathway. Nature Chemical Biology. 2014, 0 (0): . [Epub ahead of print]. Derewacz, D. K., Goodwin, C. R., McNees, C. R., McLean, J. A., Bachmann, B. O. Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism. Proceedings of the National Academy of Sciences of the United States of America. 2013, 110 (6): 2336-2341. Goodwin, C. R., Fenn, L. S., Derewacz, D. K., Bachmann, B. O., McLean, J. A. Structural Mass Spectrometry: Rapid Methods for Separation and Analysis of Peptide Natural Products. Journal of Natural Products. 2012, 67 (35): 48-53. Iverson, T. M., Panosian, T. D., Birmingham, W. R., Nannemann, D. P., Bachmann, B. O. Molecular Differences between a Mutase and a Phosphatase: Investigations of the Activation Step in Bacillus cereus Phosphopentomutase. Biochemistry. 2012, 51 (9): 1964-1975. Du, Y., Derewacz, D. K., Deguire, S. M., Teske, J., Ravel, J., Sulikowski, G. A. Biosynthesis of the apoptolidins in Nocardiopsis sp FU 40. Tetrahedron. 2011, 67 (35): 6568-6575. Panosian, T. D., Nannemann, D. P., Watkins, G. R., Phelan, V. V., McDonald, W. H., Wadzinski, B. E., Bachmann, B. O., Iverson, T. M. Bacillus cereus Phosphopentomutase Is an Alkaline Phosphatase Family Member That Exhibits an Altered Entry Point into the Catalytic Cycle. Journal of Biological Chemistry. 2011, 286 (10): 8043-8054. Nannemann, D. P., Birmingham, W. R., Scism, R. A., Bachmann, B. O. Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis. Future Medicinal Chemistry. 2011, 3 (7): 803-819. Bachmann, B. O., McNees, R., Melancon, B. J., Ghidu, V. P., Clark, R., Crews, B. C., DeGuire, S. M., Marnett, L. J., Sulikowski, G. A. Light-Induced Isomerization of Apoptolidin A leads to Inversion of C2-C3 Double Bond Geometry. Organic Letters. 2010, 12 (13): 2944-2947. Panosian, T. D., Nannemann, D. P., Bachmann, B. O., Iverson, T. M. Crystallization and preliminary X-ray analysis of a phosphopentomutase from Bacillus cereus. ACTA Crystallographica Section F-Structural Biology and Crystallization Communications. 2010, 66: 811-814. Akif, M., Ntai, I., Sturrock, E. D., Isaac, R. E., Bachmann, B. O., Acharya, K. R. Crystal structure of a phosphonotripeptide K-26 in complex with angiotensin converting enzyme homologue (AnCE) from Drosophila melanogaster. Biochemical and Biophysical Research Communications. 2010, 398 (3): 532-536. Vey, J. L., Al-Mestarihi, A., Hu, Y., Funk, M. A., Bachmann, B. O., Iverson, T. M. Structure and Mechanism of ORF36, an Amino Sugar Oxidizing Enzyme in Everninomicin Biosynthesis. Biochemistry. 2010, 49(43): 9307-9317.