个人简介

Ph.D., University of Texas at Austin, 1998

研究领域

Nanoparticle Biomimics Electronanalytical Chemistry Chemical Biology Bioanalytical Chemistry Analytical Chemistry

Multianalyte Microphysiometry Analytical chemistry often leads the forefront of scientific discovery, as new instrumentation allows us to perform new experiments. Our group has created multianalyte microphysiometry by combining microfluidic technologies with electrochemical detection to study the dynamic behaviors of metabolic pathways. We are developing new multianalyte microphysiometry methods with applications in cancer, diabetes, and toxicology. We have added electrochemical detectors for many metabolic analytes into the microfluidic chamber to give a complete dynamical picture of the live cell population. Nanoparticle Biomimics The ability to mimic biomolecular recognition requires the generation of nanoscale structures that faithfully reproduce the lock & key motif of protein binding. We have designed biomimics that present targeted linear and loop peptide structures on the surface of monolayer protected gold nanoparticles. These biomimics are useful for calibrating immunoassays, especially in our immunosensor work with the quartz crystal microbalance. Electrochemistry on the Nanoscale Electron transfer in nanometer-size chemical systems is an important process for the creation of macromolecular electronics. We are interested in the electrochemistry of metallic nanoparticles, redox proteins like Photosystem I, and other electroactive nanomaterials that bridge the gap between bulk solids and discrete molecules in the development of electronic devices using nanotechnology.

近期论文

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Leblanc, G., Gizzie, E., Yang, S., Cliffel, D. E., Jennings, G. K. Photosystem I Protein Films at Electrode Surfaces for Solar Energy Conversion. Langmuir. 2014, 0 (0): [Epub ahead of print]. Gunther, D., LeBlanc, G., Prasai, D., Zhang, J. R., Cliffel, D. E., Bolotin, K. I., Jennings, G. K. Photosystem I on Graphene as a Highly Transparent, Photoactive Electrode. Langmuir. 2013, 29 (13): 4177-4180. Wikswo, J. P., Block, F. E., Cliffel, D. E., Goodwin, C. R., Marasco, C. C., Markov, D. A., McLean, D. L., McLean, J. A., McKenzie, J. R., Reiserer, R. S., Samson, P. C., Schaffer, D. K., Seale, K. T., Sherrod, S. D. Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems. IEEE Transactions on Biomedical Engineering. 2013, 60 (3): 682-690. Kimmel, D. W., Dole, W. P., Cliffel, D. E. Application of multianalyte microphysiometry to characterize macrophage metabolic responses to oxidized LDL and effects of an apoA-1 mimetic. Biochemical and Biophysical Research Communications. 2013, 431 (2): 181-185. Simpson, C. A., Salleng, K. J., Cliffel, D. E., Feldheim, D. L. In vivo toxicity, biodistribution, and clearance of glutathione-coated gold nanoparticles. NanoMedicine-NanoTechnology Biology and Medicine. 2013, 9 (2): 257-263. Harkness, K. M., Turner, B. N., Agrawal, A. C., Zhang, Y. B., McLean, J. A., Cliffel, D. E. Biomimetic monolayer-protected gold nanoparticles for immunorecognition. Nanoscale. 2012, 4 (13): 3843-3851. Harkness, K. M., Tang, Y., Dass, A., Pan, J., Kothalawala, N., Reddy, V. J., Cliffel, D. E., Demeler, B., Stellacci, F., Bakr, O. M., McLean, J. A. Ag-44(SR)(30)(4-): a silver-thiolate superatom complex. Nanoscale. 2012, 4 (14): 4269-4274. McKenzie, J. R., Palubinsky, A. M., Brown, J. E., McLaughlin, B., Cliffel, D. E. Metabolic Multianalyte Microphysiometry Reveals Extracellular Acidosis is an Essential Mediator of Neuronal Preconditioning. ACS Chemical Neuroscience. 2012, 3 (7): 510-518. Harry, R. S., Hiatt, L. A., Kimmel, D. W., Carney, C. K., Halfpenny, K. C., Cliffel, D. E., Wright, D. W. Metabolic Impact of 4-Hydroxynonenal on Macrophage-Like RAW 264.7 Function and Activation. Chemical Research in Toxicology. 2012, 25 (8): 1643-1651. LeBlanc, G., Chen, G. P., Jennings, G. K., Cliffel, D. E. Photoreduction of Catalytic Platinum Particles Using Immobilized Multilayers of Photosystem I. Langmuir. 2012, 28 (21): 7952-7956. Hiatt, L. A., McKenzie, J. R., Deravi, L. F., Harry, R. S., Wright, D. W., Cliffel, D. E. A printed superoxide dismutase coated electrode for the study of macrophage oxidative burst. Biosensors & Bioelectronics. 2012, 33 (1): 128-133. Kimmel, D. W., LeBlanc, G., Meschievitz, M. E., Cliffel, D. E. Electrochemical Sensors and Biosensors. Analytical Chemistry. 2012, 84 (2): 685-707. Harkness, K. M., Balinski, A., McLean, J. A., Cliffel, D. E. Nanoscale Phase Segregation of Mixed Thiolates on Gold Nanoparticles. Angewandte Chemie-International Edition. 2011, 50 (45): 10554-10559. Wang, B., Wright, D., Cliffel, D., Haglund, R., Pantelides, S.T. Ionization-Enhanced Decomposition of 2,4,6-Trinitrotoluene (TNT) Molecules. Journal of Physical Chemistry A. 2011, 115 (28): 8142-8146. Simpson, C.A., Agrawal, A.C., Balinski, A., Harkness, K.M., Cliffel, D.E. Short-Chain PEG Mixed Monolayer Protected Gold Clusters Increase Clearance and Red Blood Cell Counts. ACS NANO. 2011, 5 (5): 3577-3584. Ciesielski, P.N., Cliffel, D.E., Jennings, G.K. Kinetic Model of the Photocatalytic Effect of a Photosystem I Monolayer on a Planar Electrode Surface. Journal of Physical Chemistry A. 2011, 115 (15): 3326-3334.