个人简介

Ph.D., University of Wyoming, 1987

研究领域

Analytical Chemistry Chemical Biology VICB Bioanalytical Chemistry

Our group interests center around multidisciplinary bioanalytical and biomedical research: •the application of lasers to nanoscale chemical and biochemical analysis, and the use of micro-fluidics for onchip patterning, high throughput screening, proteomics and point of care analysis. •the synthesis, characterization, and application of exogenous markers (particularly multi-modal signaling agents) for early disease detection, diagnosis, and in-vitro assays.

近期论文

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Samuelson, L. E., Anderson, B. M., Bai, M. F., Dukes, M. J., Hunt, C. R., Casey, J. D., Han, Z. Q., Papadopoulos, V., Bornhop, D. A self-internalizing mitochondrial TSPO targeting imaging probe for fluorescence, MRI and EM. RSC Advances. 2014, 4 (18): 9003-9011. Adams, N. M., Olmsted, I. R., Haselton, F. R., Bornhop, D. J., Wright, D. W. The effect of hybridization-induced secondary structure alterations on RNA detection using backscattering interferometry. Nucleic Acids Research. 2013, 41 (9): e103. Bai, M. F., Bornhop, D. J. Recent Advances in Receptor-Targeted Fluorescent Probes for In Vivo Cancer Imaging. Current Medicinal Chemistry. 2012, 19 (28): 4742-4758. Haddad, G. L., Young, S. C., Heindel, N. D., Bornhop, D. J., Flowers, R. A. Back-Scattering Interferometry: An Ultrasensitive Method for the Unperturbed Detection of Acetylcholinesterase-Inhibitor Interactions. Angewandte Chemie-International Edition. 2012, 51 (44): 11126-11130. Wyatt, S. K., Manning, H. C., Bai, M. F., Ehtesham, M., Mapara, K. Y., Thompson, R. C., Bornhop, D. J. Preclinical Molecular Imaging of the Translocator Protein (TSPO) in a Metastases Model Based on Breast Cancer Xenografts Propagated in the Murine Brain. Current Molecular Medicine. 2012, 12 (4): 458-466. Kussrow, A., Enders, C. S., Bornhop, D. J. Interferometric Methods for Label-Free Molecular Interaction Studies. Analytical Chemistry. 2012, 84 (2): 779-792. Olmsted, I. R., Xiano, Y., Cho, M., Csordas, A. T., Sheehan, J. H., Meiler, J.,Soh, H. T. Measurement of Aptamer-Protein Interactions with Back-Scattering Interferometry. Analytical Chemistry. 2011, 83 (23): 8867-8870. Lau, J. L., Baksh, M. M., Fiedler, J. D., Brown, S. D., Kussrow, A., Bornhop, D. J., Ordoukhanian, P., Finn, M. G. Evolution and Protein Packaging of Small-Molecule RNA Aptamers. ACS NANO. 2011, 5 (10): 7722-7729. Baksh, M. M., Kussrow, A. K., Mileni, M., Finn, M. G. Label-free quantification of membrane-ligand interactions using backscattering interferometry. Nature Biotechnology. 2011, 29 (4): 357-U173. Luke, Z., Moss, F., Loukachevitch, L. V., Bornhop, D. J. , Wagner, C. Histone Demethylase LSD1 Is a Folate-Binding Protein. Biochemistry. 2011, 50 (21): 4750-4756. Sexton, M., Woodruff, G., Horne, E. A., Lin, Y. H., Muccioli, G. G., Bai, M. F., Stern, E., Bornhop, D. J., Stella, N. NIR-mbc94, a Fluorescent Ligand that Binds to Endogenous CB(2) Receptors and Is Amenable to High-Throughput Screening. Chemistry & Biology. 2011, 18 (5): 563-568. Pesciotta, E., Bornhop, D. J. , Fowers II, A.A. Back-scattering interferometry: A Versatile Platform for the Study of Free-Solution versus Surface -Immobilized Hybridization. Chemistry: An Asian Journal. 2011, 6 (1): 70-3. PMID: 21082726 Baksh, M. M. , Kussrow, A., Mileni, M., Finn, M. G., Bornhop, D. J. Quantitation of Membrane-Ligand Interactions Using Backscattering Interferometry. Nature Biotechnology. 2011, Mar 13. DOI: 10.1038/nbt.1790. PMID: 21399645 Kussrow, A. , Baksh, M. M. , Bornhop, D. J. , Finn, M. G. Universal sensing by transduction of antibody binding with backscattering interferometry. Chembiochem. 2011, 12 (3): 367-70. Kussrow, A., Enders, C. S., Castro, A. R., Cox, D. L., Ballard, R. C., Bornhop, D. J. The potential of backscattering interferometry as an in vitro clinical diagnostic tool for the serological diagnosis of infectious disease. Analyst. 2010, 135 (7): 1535-1537.