研究领域
1. 糖基化修饰对多肽与蛋白的结构功能的影响
利用固相多肽合成，生物物理， 及纳米技术解析糖基化修饰对蛋白错误折叠和自组装的抑制机理。
结合分子生物方法和生物化学方法解析糖基化修饰对抗体结构及功能的影响，在分子水平上调控改善抗体的生物活性。
2.藻毒素anatoxin-a的快速特异性检测
近期论文
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Chong Li, Marzena Pazgier, Jing Li, Changqing Li, Min Liu, Guozhang Zou, Zhenyu Li, Jiandong Chen, Sergey G. Tarasov, Wei-Yue Lu, and Wuyuan Lu*. Limitations of peptide retro-inverso isomerization in molecular mimicry, and why. J Biol. Chem (in press)
Gang Wei, Marzena Pazgier, Erik de Leeuw, Mohsen Rajabi, Jing Li, Guozhang Zou, Grace Jung, Weirong Yuan, Wei-Yue Lu, Robert I. Lehrer*, and Wuyuan Lu*. Trp-26 Imparts Functional Versatility to Human α-Defensin HNP1. J Biol. Chem. (in press)
Gang Wei, Erik de Leeuw, Marzena Pazgier, Weirong Yuan, Guozhang Zou, Jianfeng Wang, Bryan Ericksen, Wei-Yue Lu, Robert I. Lehrer, and Wuyuan Lu*. Through the looking glass: Mechanistic insights from enantiomeric human defensins. J Biol. Chem 2009, 284, 29180-29192.
Erik de Leeuw*, Mohsen Rajabi, Guozhang Zou, Marzena Pazgier and Wuyuan Lu. Selective arginines are important for the antibacterial activity and host cell interaction of human -defensin 5 FEBS Lett 2009, 583, 2507-2512
Marzena Pazgier, Min Liu, Guozhang Zou, Weirong Yuan, Changqing Li, Cong Li, Jing Li, Juahdi Monbo, Davide Zella, Sergey Tarasov, and Wuyuan Lu*. Structural basis for high-affinity peptide inhibition of P53 interactions with MDM2 and MDMX Proc. Natl. Acad. Sci. USA 2009, 106, 4665-4670.
Guozhang Zou*. Structural and functional elements of human alpha defensins Curr Top Pept Protein Res 2008, 9, 37-46.
Cong Li, Min Liu, Juandi Monbo, Guozhang Zou, Changqing Li, Weirong Yuan, Davide Zella, Wei-Yue Lu, and Wuyuan Lu*. Turning a scorpion toxin into an antitumor miniprotein J. Am. Chem. Soc. 2008, 130, 13546-13548.
Guozhang Zou, Erik de Leeuw, Jacek Lubkowski, and Wuyuan Lu*. Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its pro peptide J. Mol. Biol. 2008, 381, 1281-1291
Guozhang Zou, Erik de Leeuw, Chong Li, Changqing Li, Pengyun Zeng, Jacek Lubkowski, Wei-Yue Lu, and Wuyuan Lu* Toward understanding the cationicity of defensins: Arg and Lys versus their noncoded analogs J. Biol. Chem. 2007, 282, 19653-19665.
Jingsong Wang, Hengguang Li, Guozhang Zou, and Lai-Xi Wang*. Novel template-assembled obligosaccharide clusters as HIV-1 candidate vaccine: design, synthesis, and binding to human antibody 2G12 Org. Biomol. Chem. 2007, 5, 1529-1540.
Xianqun Li, Guozhang Zou, Weirong Yuan, and Wuyuan Lu*. Defining the native disulfide topology in the somatomedin B domain of human vitronectin. J. Biol. Chem. 2007, 282, 5318-5326
Zhibin Wu, Xiangqun Li, Bryan Ericksen, Erik de Leeuw, Guozhang Zou, Pengyun Zeng, Cao Xie, Cong Li, Jacek Lubkowski, Wei-Yue Lu, and Wuyuan Lu*. Impact of pro segments on the folding and function of human neutrophil α-defensins J. Mol. Biol. 2007, 368, 537-549.
Guozhang Zou and Gregory L. Boyer*. Synthesis and Properties of Different Metal Complexes of the Siderophore Desferriferricrocin. BioMetals 2005, 18, 63-74.
Yuqing Qi, Guozhang Zou, Daizheng Liao, Zonghui Jiang*, and Genglin Wang Synthesis and properties of the complexes of gadolinium with nitronyl nitroxides. Pol. J. Chem. 1997, 71, 1365-1369.
Xiangjun Meng, Huizhong Kou, Guozhang Zou, Daizheng Liao*, Zonghui Jiang*, and Genglin Wang Synthesis and magnetism of dinuclear Cu(II) complexes bridged through iodanilic acid anion. Yingyong Huaxue 1997, 14, 60-62.
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