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招生方向 抗肿瘤纳米药物 纳米生物效应和安全性 组织工程材料 教育背景 2003-09--2006-07 军事医学科学院 博士 2000-09--2003-07 河北医科大学 硕士 1995-09--2000-07 天津医科大学 学士 工作简历 2018-03~现在, 国家纳米科学中心, 研究员 2015-03~2018-03,国家纳米科学中心, 特聘研究员 2012-04~2015-03,国家纳米科学中心, 副研究员 2009-04~2012-03,国家纳米科学中心, 助理研究员 2006-08~2009-04,中国科学院化学所, 博士后 2003-09~2006-07,军事医学科学院, 博士 2000-09~2003-07,河北医科大学, 硕士 1995-09~2000-07,天津医科大学, 学士 教授课程 纳米能源环境材料 奖励信息 (1) 中国毒理学会优秀青年科技奖, 其他, 2018 (2) 国家自然科学二等奖, 二等奖, 国家级, 2018 (3) 中国科学院卢嘉锡青年人才奖, 院级, 2013 专利成果 ( 1 ) 一种功能化引导肌组织再生膜及其制备方法和应用, 2016, 第 2 作者, 专利号: 201610461624.2 ( 2 ) 一种纳米纤维膜及其制备方法和应用, 2016, 第 2 作者, 专利号: 201611254386.4 ( 3 ) 一种抗氧化静电纺丝膜及其制备方法和应用, 2017, 第 2 作者, 专利号: 201710031197.9 ( 4 ) 一种具有吸附过滤功能的静电纺丝膜及其制备方法和应用, 2017, 第 2 作者, 专利号: 201710386651.2 ( 5 ) 一种静电纺丝膜及其制备方法和应用, 2017, 第 2 作者, 专利号: 201710385104.2 ( 6 ) 一种雷公藤红素/盐酸阿霉素自组装纳米药物及其制备方法和应用, 2017, 第 3 作者, 专利号: 201711217672.8 科研项目 ( 1 ) 功能化富勒烯衍生物增强免疫活性作用机制的研究, 主持, 国家级, 2011-01--2013-12 ( 2 ) 新型药用纳米材料与纳米药物的研究, 参与, 部委级, 2006-01--2011-12 ( 3 ) 重要纳米材料的生物效应机制与安全性评价研究, 参与, 国家级, 2011-01--2016-12 ( 4 ) 基于肿瘤微环境调控的抗肿瘤纳米材料设计和机制研究, 参与, 国家级, 2012-01--2017-12 ( 5 ) 纳米生物效应与安全性, 主持, 国家级, 2017-01--2019-12 ( 6 ) 利用同步辐射技术研Gd@C82(OH)22调控肿瘤细胞EMT的作用机制, 主持, 国家级, 2016-01--2018-12 ( 7 ) 食品用纳米材料的 ADME 研究与生物安全性评价方法, 主持, 国家级, 2017-01--2021-12 参与会议 (1)The Surface Effects of Gold Nanorods on Cell Fates 第九届世界生物材料大会 Liming Wang and Ying Liu 2012-06-01 (2)Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment 金纳米颗粒研讨会 ligeng xu 2012-05-01

近期论文

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(1) Poly(lactic-co-glycolic acid)/Polycaprolactone Nanofibrous Membranes for High-Efficient Capture of Nano- and Microsized Particulate Matter, J Biomed Nanotechnol, 2018, 通讯作者 (2) Nucleosome-inspired nanocarrier obtains encapsulation efficiency enhancement and side effects reduction in chemotherapy by using fullerenol assembled with doxorubicin, Biomaterials, 2018, 第 5 作者 (3) Molecular mechanism of Gd@C82(OH)22 increasing collagen expression: Implication for encaging tumor, Biomaterials, 2018, 第 6 作者 (4) Early-life exposure to three size-fractionated ultrafine and fine atmospheric particulates in Beijing exacerbates asthma development in mature mice, Part Fibre Toxicol, 2018, 第 7 作者 (5) In vivo aggregation-induced transition between T1 and T2 relaxations of magnetic ultra-small iron oxide nanoparticles in tumor microenvironment, Nanoscale, 2017, 第 5 作者 (6) Fullerenol inhibits the cross-talk between bone marrow-derived mesenchymal stem cells and tumor cells by regulating MAPK signaling, Nanomedicine, 2017, 第 3 作者 (7) Dual-Mode Imaging-Guided Synergistic Chemo- and Magnetohyperthermia Therapy in a Versatile Nanoplatform to Eliminate Cancer Stem Cells, ACS Appl Mater Interfaces, 2017, 第 10 作者 (8) C60(OH)n-loaded nano fibrous membranes protect HaCaT cells from ROS-associated damage, Chinese Chem Lett, 2017, 通讯作者 (9) Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes, Sci Bull, 2017, 通讯作者 (10) Mussel Inspired Polynorepinephrine Functionalized Electrospun Polycaprolactone Microfibers for Muscle Regeneration, Sci Rep, 2017, 第 1 作者 (11) A Versatile Imaging and Therapeutic Platform Based on Dual-Band Luminescent Lanthanide Nanoparticles toward Tumor Metastasis Inhibition, ACS Nano, 2016, 第 6 作者 (12) Silver Nanoparticles Induced Oxidative and Endoplasmic Reticulum Stresses in Mouse Tissues: Implications for the Development of Acute Toxicity after Intravenous Administration, Toxicol Res-UK, 2016, 第 4 作者 (13) Gd-Hybridized Plasmonic Au-Nanocomposites Enhanced Tumor-Interior Drug Permeability in Multimodal Imaging-Guided Therapy, Adv Mater, 2016, 第 3 作者 (14) Polyhydroxylated Fullerenols Regulate Macrophage for Cancer Adoptive Immunotherapy and Greatly Inhibit the Tumor Metastasis, Nanomedicine: NBM, 2016, 通讯作者 (15) Superstable Magnetic Nanoparticles in Conjugation with Near-Infrared Dye as a Multimodal Theranostic Platform, ACS Appl Mater Inter, 2016, 通讯作者 (16) Rapid Degradation and High Renal Clearance of Cu3BiS3 Nanodots for Efficient Cancer Diagnosis and Photothermal Therapy in Vivo, ACS Nano, 2016, 通讯作者 (17) Role of Nanotechnology in HIV/AIDS Vaccine Development, Adv Drug Deliver Rev, 2016, 第 1 作者 (18) Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor, Nat Commun, 2015, 第 1 作者 (19) Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells, Nanoscale, 2015, 通讯作者 (20) Parallel Comparative Studies on Mouse Toxicity of Oxide Nanoparticle- and Gadolinium-Based T1 MRI Contrast Agents, ACS Nano, 2015, 第 5 作者 (21) Size- and surface chemistry-dependent pharmacokinetics and tumor accumulation of engineered gold nanoparticles after intravenous administration, Metallomics, 2015, 第 6 作者 (22) Au@Pt nanostructure: a novel photothermal conversion agent for cancer therapy, Nanoscale, 2014, 第 6 作者 (23) Right or left: the role of nanoparticles in pulmonary diseases, Int J Mol Sci, 2014, 通讯作者 (24) Polyhydroxylated Metallofullerenols Stimulate IL-1 Secretion of Macrophage through TLRs/MyD88/NF-κB Pathway and NLRP3 Inflammasome Activation, Small, 2014, 第 1 作者 (25) The Influence on Cell Cycle and Cell Division by Various Cadmium-Containing Quantum Dots, small, 2013, 通讯作者 (26) Morphologically Virus-like Fullerenol Nanoparticles Act as the Dual-functional Nanoadjuvant for HIV-1 Vaccine, Adv Mater, 2013, 第 5 作者 (27) 纳米材料对内分泌系统影响的研究进展, Nanotoxicity: the growing need for study in the endocrine system., Small, 2013, 第 1 作者 (28) 碳纳米管的毒性来源, Understanding the Toxicity of Carbon Nanotubes., Accounts of Chemical Research, 2013, 第 1 作者 (29) 富勒烯衍生物用于肿瘤的诊断和治疗, Fullerenes for Cancer Diagnosis and Therapy: Preparation, Biological and Clinical Perspectives, Current Drug Metabolism, 2012, 通讯作者 (30) Gd@C82(OH)22抗胰腺癌肿瘤生长机制研究, Molecular mechanism of pancreatic tumor metastasis inhibition by Gd@C82(OH)22 and its implication for de novo design of nanomedicine, PNAS, 2012, 第 4 作者 (31) 功能性富勒烯衍生物在肿瘤治疗中的应用, Application of Functionalized Fullerenes to Tumor Theranostics, Theranostics, 2012, 通讯作者 (32) 金纳米棒可以作为DNA疫苗的载体应用于HIV治疗, Surface-engineered gold nanorods: promising DNA vaccine adjuvant for HIV-1 treatment., Nano Lett, 2012, 通讯作者 (33) 未修饰石墨烯通过MAPK和TGF-beta通路诱导巨噬细胞的凋亡, The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways, Biomaterials, 2012, 第 1 作者 (34) Au@Pt模拟氧化酶和过氧化物酶应用于免疫分析, Au@Pt Nanostructures as Oxidase and Peroxidase Mimetics for Use in Immunoassays, Biomaterials, 2011, 第 2 作者 (35) 纳米材料的细胞摄入,内吞途径和细胞毒性, Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials., small, 2011, 第 2 作者 (36) 铜纳米颗粒剂量依赖性的毒性和潜在性神经系统影响研究, The dose-dependent toxicological effects and potential perturbation on the neurotransmitter secretion in brain following intranasal instillation of copper nanoparticles., Nanotoxicology, 2011, 第 2 作者 (37) 纳米颗粒进入细胞不与有丝分裂纺锤体和染色体直接作用, Intracellular dynamics of cationic and anionic polystyrene nanoparticles without direct interaction with mitotic spindle and chromosomes., Biomaterials, 2011, 第 3 作者 (38) 碳纳米管与血液蛋白质结合降低细胞毒性, Binding of blood proteins to carbon nanotubes reduces cytotoxicity., Proc Natl Acad Sci U S A, 2011, 第 4 作者 (39) 碳纳米管与血浆蛋白的相互作用, The interaction of serum proteins with carbon nanotubes depend on the physicochemical properties of nanotubes., J Nanosci Nanotechnol, 2011, 第 3 作者 (40) 金纳米棒可以选择性进入肿瘤细胞的线粒体:在肿瘤治疗的应用前景, Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy, Nano Lett, 2011, 第 1 作者 (41) 不同表面化学和长径比的金纳米棒对细胞摄入的影响, Chemistry and Aspect Ratio Mediated Cellular Uptake of Au Nanorods, Biomaterials, 2010, 第 2 作者 (42) 富勒醇抗乳腺癌生长和转移研究, Studies on anti-tumor and antimetastatic activities of fullerenol in a mouse breast cancer model, Carbon, 2010, 第 2 作者 (43) 环境纳米技术在食品工业中的应用和毒性评价, Applications and toxicological issues surrounding nanotechnology in the food industry, Pure Applied Chem, 2010, 第 2 作者 (44) 多技术分析金纳米棒在动物体内的摄入、潴留和化学形态, Characterization of gold nanorods in vivo by integrated analytical techniques: their uptake, retention, and chemical forms, Anal Bioanal Chem, 2010, 第 4 作者 (45) 小鼠气管滴入打印机粉尘肺脏反应的研究, Pulmonary responses to printer toner particles in mice after intratracheal instillation, Toxicol Lett, 2010, 第 2 作者 (46) Gd@C82(OH)22在荷瘤小鼠不同组织的亚细胞分布研究, Subcellular distribution of polyhydroxylated metallofullerene Gd@C82(OH)22 in different tissues of tumor-bearing mice., J Nanosci Nanotechnol, 2010, 第 3 作者 (47) 功能化富勒烯对肺癌转移小鼠氧化应激功能的调节, Modulation of oxidative stress by functionalized fullerene materials in the lung tissues of female C57/BL mice with a metastatic Lewis lung carcinoma., J Nanosci Nanotechnol, 2010, 第 4 作者 (48) Gd@C82(OH)22调节Th1/Th2细胞因子的释放诱导TNF-α介导的细胞免疫调节, The effect of Gd@C82(OH)22 nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-α mediated cellular immunity, Biomaterials, 2009, 第 1 作者 (49) C60(OH)20诱导TNF-α介导的细胞免疫, Immunostimulatory Properties and enhanced TNF-α Mediated Cellular Immunity for tumor therapy By C60(OH)20 Nanoparticles, Nanotechnology, 2009, 第 1 作者

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