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个人简介

王浩 研究员,洪堡学者,杰青,中青年科技创新领军人才。现任国家纳米科学中心纳米生物效应与安全性实验室主任 2005年于南开大学获理学博士学位。之后在德国维尔茨堡大学作为洪堡研究员进行研究,2007年在美国加州大学洛杉矶分校医学院Crump 分子成像研究所和加州纳米系统研究中心从事纳米技术在癌症诊断与治疗方面的研究。2011年加入国家纳米科学中心中国科学院纳米生物效应与安全性重点实验室。

研究领域

纳米生物材料的设计与合成 生物效应与安全性研究 未来生物技术,包括药物递送,生物成像,肿瘤疫苗,靶向蛋白降解技术等

近期论文

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Yi Wang# ,Sheng-Lin Qiao# ,Jie Wang ,Meng-Zhen Yu ,Nan-Nan Wang ,Muhetaerjiang Mamuti ,Hong-Wei An ,Yao-Xin Lin* ,Hao Wang*. Engineered CpG-Loaded Nanorobots Drive Autophagy-Mediated Immunity for TLR9-Positive Cancer Therapy. Adv. Mater., 202306248. Ya-Nan Li#, Hong-Wen Liang#, Chun-Lin Zhang, Yan-Mei Qiu, David Wang, Hai-Ling Wang, An-Qi Chen, Can-Dong Hong, Lei Wang*, Hao Wang*, Bo Hu*. Ophthalmic Solution of Smart Supramolecular Peptides to Capture Semaphorin 4D against Diabetic Retinopathy. Sci. Adv., 2023, 10, 2203351. Yaqiong Yan, Lei Wang and Hao Wang*. Functional Peptides from One-bead One-compound High-throughput Screening Technique. Chem. Res. Chin. Univ., 2023, 39, 83-91.  Yuxing Jiang#, Hongtao Rong#, Yifan Wang#, Shange Liu, Peng Xu, Zhen Luo, Lamei Guo, Tao Zhu*, Hongpan Rong, Dingsheng Wang, Jiatao Zhang*, Yu Yi* and Hao Wang*。 Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection. Nano Res., 2023, 16, 9752-9759. Lu Wang#, Bo Fu#, Da-Yong Hou#, Yu-Lin Lv#, Guang Yang#, Cong Li, Jia-Chen Shen, Bin Kong, Li-Bo Zheng, Yu Qiu, Hong-Lei Wang, Chen Liu, Jian-Ji Zhang, Shi-Yu Bai, Li-Li Li*, Hao Wang*, Wan-Hai Xu*. PKM2 allosteric converter: A self-assembly peptide for suppressing renal cell carcinoma and sensitizing chemotherapy. Biomaterials, 2023, 296,122060. Anqi Wang, Kai Yue*, Weishen Zhong, Genpei Zhang, Lei Wang, Hao Wang, Hua Zhang, Xinxin Zhang. Ligand-receptor interaction in the specific targeting of biomimetic peptide nanoparticles to lysophosphatidylcholine.Int. J. Biol. Macromol., 2023, 227, 193-202. Yi-Jing Li, Lingze Zhang, Ming-Hao Pang, Pei-Pei Yang, Lu-Ming Guo, Kuo Zhang, Da-Yong Hou, Lei Wang*, Hao Wang*, Hui Cao*. Screened peptides from one-bead one-compound technique extend half-life of peptide drugs in circulation through binding to albumin. Chin. Chem. Lett., 2023,108530, Hong-Wei An#, Da-YongHou#, Jia Yang, Zi-QiWang, Man-DiWang, Rui Zheng, Ni-YuanZhang, Xing-JieHu, Zhi-JiaWang, Lu Wang, Di Liu, Jun-FengHao,WanhaiXu*, YuliangZhao*, HaoWang*. A bispecific glycopeptide spatiotemporally regulates tumor microenvironment for inhibiting bladder cancer recurrence.Sci. Adv., 2023, 9,eabq8225. Yong-Dan Zhao#, Hong-Wei An#, Muhetaerjiang Mamuti#, Xiang-Zhong Zeng, Rui Zheng, Jia Yang, Wei Zhou, Yuxin Liang, Gege Qin, Da-Yong Hou, Xiaolong Liu, Hao Wang*, Yuliang Zhao*, Xiaohong Fang*. Reprogramming Hypoxic Tumor-Associated Macrophages by Nanoglycoclusters for Boosted Cancer Immunotherapy.Adv. Mater., 2023, 35, 2211332.  Qian-Ting Wang, Yi-Xuan Liu, Jie Wang, Hao Wang*. Advances in Cancer Nanovaccines: Harnessing Nanotechnology for Broadening Cancer Immune Response.ChemMedChem., 2023, 18, e202200673.  Pengsheng Fan#, Yinghua Guan#, Xiaoying Zhang, Jiaqi Wang, Yinsheng Xu, Benli Song, Suling Zhang, Hao Wang*,Ya Liu* and Zeng-Ying Qiao*.Cell membrane-specific self-assembly of peptide nanomedicine induces tumor immunogenic death to enhance cancer therapy.Nanoscale Horiz., 2023, 8, 1226-1234 Su-Ling Zhang, Cong Liu, Zhi-Xiang Li, Ying-Hua Guan, Lin Ge, Qijun Sun, Jun-An Liu, Yong-Jun Lin, Zi-Xin Yang*, Zeng-Ying Qiao*, Hao Wang*. Sonoactivated Cascade Fenton Reaction Enhanced by Synergistic Modulation of Electron–Hole Separation for Improved Tumor Therapy.Adv. Healthcare Mater., 2023, 2300982. Ziqi Wang#, Changhao Zhao#, Yaowei Li#, Jiaqi Wang, Dayong Hou, Lu Wang, Yueze Wang, Xunwei Wang, Xiao Liu, Hao Wang*, Wanhai Xu*. Photostable Cascade-Activatable Peptide Self-Assembly on a Cancer Cell Membrane for High-Performance Identification of Human Bladder Cancer. Adv. Mater., 2023, 2210732. Xing-Jie Hu#, Ni-Yuan Zhang,# Da-Yong Hou#, Zhi-Jia Wang, Man-Di Wang, Li Yi, Zhang-Zhi Song, Jian-Xiao Liang, Xiang-Peng Li, Hong-Wei An, Wanhai Xu, Hao Wang*. In Vivo Self-Assembled Bispecific Nano-Blocker for Enhancing Tumor Immunotherapy. Adv. Mater., 2023, 2303831. Ni-Yuan Zhang#, Da-Yong Hou#, Xing-Jie Hu, Jian-Xiao Liang, Man-Di Wang, Zhang-Zhi Song, Li Yi, Zhi-Jia Wang, Hong-Wei An*, Wanhai Xu*, Hao Wang*. Nano Proteolysis Targeting Chimeras (PROTACs) with Anti-Hook Effect for Tumor Therapy. Angew. Chem. Int. Ed., 2023, e202308049. Pei-Pei Yang#, Xin-Wei Ye#, Mei-Qin Liu#, Jin-Xuan Yang#, Xiao-Li Feng, Yi-Jing Li, Kuo Zhang, Hong-Wen Liang, Yu Yi, Lei Wang*, Yi-Xuan Liu, Xing-Lou Yang*, Zheng-Li Shi, Li-Qiang Feng, Ling Chen, Yintong Xue, Qiang Pan-Hammarstr?m, Hao Wang*, Yuliang Zhao*. Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2. Adv. Healthcare Mater., 2023, 2300673. Yan-Lei Fan#, Ni-Yuan Zhang#, Da-Yong Hou#, Yi Hao, Rui Zheng, Jia Yang, Zhi Fan*, Hong-Wei An*, Hao Wang*. Programmable Peptides Activated Macropinocytosis for Direct Cytosolic Delivery. Adv. Healthcare Mater., 2023, 2301162. Yu Yi#, Hong-Wei An#, Hao Wang*. Intelligent Biomaterialomics: Molecular Design, Manufacturing, And Biomedical Applications. Adv. Mater., 2023, 2305099. Ning-Bo Yi, Xing-Jie Hu, Fei Wang, Si-Yi Chen, Xiao-Xue Xu, Xin Li, Hao Wang, Taolei Sun, Zeng-Ying Qiao* and Dong-Bing Cheng*. Endogenous formaldehyde responsive fluorescent probe for bioimaging. Nano Res., 2023, DOI: 10.1007/s12274-023-5766-z Xue-Feng Gong, Yi-Jing Li, Dong Wang, Hui Cao, Zhou Yang, Hao Wang, Lei Wang*. Process-biomimetic macromolecular materials for in vivo applications. Prog. Mater. Sci., 2023, 131, 101015. Si Sun, Hong-Wen Liang, Hao Wang*, and Quanming Zou*. Light-Triggered Self-Assembly of Peptide Nanoparticles into Nanofibers in Living Cells through Molecular Conformation Changes and H-Bond Interactions. ACS Nano., 2022, 16, 11, 18978-18989. Jiaqi Wang#, Peipei Yang#, Dayong Hou#, Yaqiong Yan, Kai Yue, Weishen Zhong, Ting Xiao, Xiuhai Wu, Ziqi Wang, Peng Wu, Lei Wang*, Hao Wang*, Wanhai Xu*.Bacteria-inspired transformable nanoparticle targets and covers residual tumor against bladder cancer recurrence.Nano Today, 2022, 45, 101551. Man-Di Wang#, Gan-Tian Lv#, Hong-Wei An, Ni-Yuan Zhang, & Hao Wang*. In Situ Self-Assembly of Bispecific Peptide for Cancer Immunotherapy. Angew. Chem. Int. Ed., 2022, 61, e202113649. Zi-Qi Wang#, Zhong-Qing Liu#, Chang-Hao Zhao#, Kuo Zhang, Zhi-Jian Kang, Tian-Rui Qu, Fan-Shu Zeng, Peng-Yu Guo, Zhi-Chao Tong, Chang-Lin Wang, Ke-Liang Wang, Hong-Lei Wang, Yin-Sheng Xu, Wan-Hui Wang, Mao-lin Chu, Lu Wang*, Zeng-Ying Qiao*, Hao Wang*, & Wanhai Xu*. An Ultrasound-Induced Self-Clearance Hydrogel for Male Reversible Contraception. ACS Nano 2022, 16, (4), 5515-5528. Da-Yong Hou#, Man-Di Wang#, Ni-Yuan Zhang#, Shaoxin Xu#, Zhi-Jia Wang, Xing-Jie Hu, Gan-Tian Lv, Jia-Qi Wang, Mei-Yu Lv, Li Yi, Lu Wang, Dong-Bing Cheng*, Taolei Sun*, Hao Wang*, & Wanhai Xu*. A Lysosome-Targeting Self-Condensation Prodrug-Nanoplatform System for Addressing Drug Resistance of Cancer Nano Letters 2022, 22 (10), 3983-3992. Jia Yang#, Rui Zheng#, Muhetaerjiang Mamuti, Da-Yong Hou, Yong-Dan Zhao, Hong-Wei An*, Hao Wang*, & Yuliang Zhao*. Oncolytic peptide nanomachine circumvents chemo resistance of renal cell carcinoma.Biomaterials, 2022, 284, 121488 Weishen Zhong, Kai Yue#, Anqi Wang, Genpei Zhang, Jiaqi Wang, Lei Wang, Hao Wang, Hua Zhang, & Xinxin Zhang. Mechanisms of deformation and drug release of targeting polypeptides based on fibronectin induction. Colloids and Surfaces B: Biointerfaces, 2022, 219, 112836 Hong-Wen Liang, Tian Jia, Xue Yong, Jing-Kun Yu, Yu Yi, Siyu Lu, Lei Wang*, & Hao Wang*. Photoinduced Single-Crystal to Single-Crystal Transformation via Conformational Change with Turn-On Fluorescence Crystal Growth & Design, 2022, 22 (4), 2082-2086 Yong Liu*, Juanjuan Li, Li Yi, & Hao Wang*. Polymeric Nanoshell-Stabilized Liquid Metal for Bactericidal Photonanomedicine ACS Applied Bio Materials, 2022, 5 (2), 779-788. Meng-Ru Ding, Qi-Lin Liang, Huan-Ge Xu, Xiang-Dan Li*, Kuo Zhang, Zi-Jin Wei, Yong-Hong Gao, Qing-Shi Zhang, Rui Huang, Huai Yang*, Lei Wang*, & Hao Wang*. Smart Peptide Defense Web In Situ Connects for Continuous Interception of IgE against Allergic Rhinitis ACS Applied Materials & Interfaces, 2022, 14, (26), 29639-29649 Kuo Zhang, Yong-Hong Gao, Wei-Shen Zhong, Hui Cao, *Kai Yue, *Lei Wang * and Hao Wang. Ca2+ accelerates peptide fifibrillogenesis via a heterogeneous secondary nucleation pathway.Nanoscale, 2022, 14, 3899–3906 Xiao-Ying Zhang#, Cong Liu#, Peng-Sheng Fan, Xue-Hao Zhang, Da-Yong Hou,Jia-Qi Wang, Hui Yang*, Hao Wang*, & Zeng-Ying Qiao*. Skin-like wound dressings with on-demand administration based on in situ peptide self assembly for skin regeneration J. Mater. Chem. B, 2022, 10, 3624. Hong-Wen Liang#, Tian Jia#, Zhen-Zhen Wang#, Jia-Qi Wang, Da-Yong Hou, Lei Wang, Xingfa Gao*, He-Lue Sun*, & Hao Wang*. Anti-solvatochromic and highly emissive twisted D–A structure with intramolecular hydrogen bond Mater. Chem. Front., 2022, 6, 512–518 Han Ren*, Xiang-Zhong Zeng*, Xiao-Xiao Zhao*, Da-yong Hou, Haodong Yao , Muhammad Yaseen, Lina Zhao, Wan-hai Xu, Hao Wang, Li-Li Li *. A bioactivated in vivo assembly nanotechnology fabricated NIR probe for small pancreatic tumor intraoperative imaging Nat. Commun., 2022, 13, 418 Kui Xiao#, Niyuan Zhang#, Feifei Li#, Dayong Hou#, Xiaoyi Zhai, Wanhai Xu* , Gelin Wang*, Hao Wang*, Liang Zhao*. Pro-oxidant response and accelerated ferroptosis caused by synergetic Au(I) release in hypercarbon-centered gold(I) cluster prodrugs Nat. Commun., 2022, 13:4669 Lu Wang, Bo Fu, Da-Yong Hou, Yulin Lv, Guang Yang, Cong Li, Jiachen Shen, Bin Kong, Libo Zheng, Yu Qiu, Honglei Wang, Chen Liu, Jianji Zhang, Li-Li Li, Hao Wang, Wanhai Xu*. PKM2 allosteric converter: a self-assembly peptide for suppressing renal cell carcinoma and sensitizing chemotherapy. Research Square [https://doi.org/10.21203/rs.3.rs-1598044/v1] Wei-Hai Chen , Qi-Wen Chen , Qian Chen , Chunyan Cui , Shun Duan , Yongyuan Kang , Yang Liu , Yun Liu, Wali Muhammad , Shiqun Shao, Chengqiang Tang, Jinqiang Wang, Lei Wang, Meng-Hua Xiong, Lichen Yin, Kuo Zhang, Zhanzhan Zhang, Xu Zhen, Jun Feng*, Changyou Gao*, Zhen Gu*, Chaoliang He*, Jian Ji*, Xiqun Jiang*, Wenguang Liu*, Zhuang Liu*, Huisheng Peng*, Youqing Shen*, Linqi Shi*, Xuemei Sun*, Hao Wang*, Jun Wang*, Haihua Xiao*, Fu-Jian Xu*, Zhiyuan Zhong*, Xian-Zheng Zhang* & Xuesi Chen*. Biomedical polymers: synthesis, properties, and applications Sci China Chem., (2022), 65. 1010–1075 Sisi Chen#, Liu Yang#, Xia Ou#, Jin-Yu Li#, Cheng-Ting Zi , Hao Wang*, Jiang-Miao Hu* & Ye Liu*. A new polysaccharide platform constructs self-adjuvant nanovaccines to enhance immune responses Journal of Nanobiotechnology (2022) 20:320 Sheng-Lin Qiao, Muhetaerjiang Mamuti, Hong-Wei An, Hao Wang*. Thermoresponsive Polymer Assemblies: From Molecular Design to Theranostics Application,Progress in Polymer Science, 2022, 131, 101578, Ni-Yuan Zhang#, Xing-Jie Hu# Hong-Wei An, Jian-Xiao Liang, Hao Wang*. Programmable design and self assembly of peptide conjugated AIEgens for biomedical applications Biomaterials, 2022, 287, 121655 Xue-Feng Gong, Yi-Jing Li, Dong Wang, Hui Cao, Zhou Yang, Hao Wang, Lei Wang*. Process-biomimetic macromolecular materials for in vivo applications Progress in Materials Science, 2023, 131, 101015 Ya-Qiong Yan, Hao Wang*, Yuliang Zhao*. Radiolabeled peptide probe for tumor imaging.Chinese Chemical Letters, 2022, 33, 7

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