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个人简介

杨延莲,博士,国家纳米科学中心研究员。1992年9月至1999年7月在山东大学化学学院进行大学本科和硕士研究生学习,1999年9月至2004年6月于北京大学化学与分子工程学院攻读博士学位并从事博士后研究。2004年7月至今,被聘为国家纳米科学中心副研究员和研究员,2007年10月-2008年11月到美国麻省理工学院生物医学工程中心做访问学者。2014年9月联合创办北京中科纳泰生物科技有限公司,任公司副总经理、首席科学家兼研发总监,2018年6月起,任公司CEO兼首席科学家。

研究领域

基于多肽纳米结构的液体活检技术、疾病相关的多肽组装结构及其调控的分子机制、基于扫描探针显微技术的纳米表征方法等。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Mei Jiang?, Yuchen Lin?, Xiaocui Fang, Mingpeng Liu, Lilusi Ma, Jingyi Liu, Mengting Chen, Yanlian Yang* ,Chen Wang *,“Enhancement of gold-nanocluster-mediated chemotherapeutic efficiency of cisplatin in lung cancer”, Journal of Materials Chemistry B,2021,9, 4895-4905,DOI: 10.1039/d1tb00276g Mingpeng Liu, Xiaocui Fang, Yanlian Yang*, Chen Wang*, “Peptide-enabled targeted delivery systems for therapeutic applications”, Front. Bioeng. Biotechnol, DOI : 10.3389/fbioe.2021.701504 Xiaocui Fang ,Kaiyue Zhang, Mei Jiang, Lilusi Ma, Jian Liu, Haiyan Xu,*,Yanlian Yang,*, Chen Wang,*,“Enhanced lymphatic delivery of nanomicelles encapsulating CXCR4-recognizing peptide and doxorubicin for the treatment of breast cancer.”, International Journal of Pharmaceutics,2021, 594:120183, DOI: 10.1016/j.ijpharm.2020.120183 Yongfang Zheng?, Xiaocui Fang?, Yanlian Yang*, Chen Wang*, “Peptide-directed delivery of drug-loaded nanocarriers targeting CD36 overexpressing cells” , Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2021, 125970, DOI: 10.1016/j.colsurfa.2020.125970 Kaiyue Zhang?, Xiaocui Fang?, Qing You, Yuchen Lin, Lilusi Ma, Shilin Xu, Yangyang Ge, Haiyan Xu,* Yanlian Yang*, and Chen Wang,* “A Novel Peptide-directed Liposomes for Targeted Combination Therapy of Breast Tumor”, Materials Advances, 2020, DOI: 10.1039/D0MA00536C. Lanlan Yu, Wenbo Zhang, Wendi Luo, Robert L. Dupont, Yang Xu, Yibing Wang, Bin Tu, Haiyan Xu, Xiaoguang Wang, Qiaojun Fang*, Yanlian Yang, Chen Wang, Chenxuan Wang*, “Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T”, Science Advances, 2020, 6(32), eabc1449, DOI: 10.1126/sciadv.abc1449. Jie Meng, Yangyang Ge, Haiyan Xing, Hui Wei, Shilin Xu, Jian Liu, Doudou Yan, Tao Wen, Min Wang, Xiaocui Fang, Lilusi Ma, Yanlian Yang, Chen Wang,* Jianxiang Wang,* Haiyan Xu*, “Synthetic CXCR4 Antagonistic Peptide Assembling with Nanoscaled Micelles Combat Acute Myeloid Leukemia”, Small, 2020, 16, 200189, DOI:10.1002/smll.202001890. Houqian Gao?, Mingzhu Liu?, Zijian Zhao, Caixia Yang, Ling Zhu,* Yanning Cai,* Yanlian Yang,* Zhiyuan Hu*, “Diagnosis of Mild Cognitive Impairment and Alzheimer’s Disease by the Plasma and Serum Amyloid-beta 42 Assay through Highly Sensitive Peptoid Nanosheet Sensor”, ACS Applied Materials & Interfaces, 2020, 12, 9693-9700, DOI: acsami.0c00370. Yimin Zou?, Lanlan Yu?, Xiaocui Fang, Yongfang Zheng, Yanlian Yang*, Chen Wang*, “Position-coded multivalent peptide–peptide interactions revealed by tryptophan-scanning mutagenesis”, Journal of Peptide Science, 2020, 26:e3273, DOI: 10.1002/psc.3273. Ruijuan Zu?, Xiaocui Fang?, Yuchen Lin, Shilin Xu, Jie Meng, Haiyan Xu*, Yanlian Yang *, Chen Wang*, “Peptide-enabled receptor-binding-quantum dots for enhanced detection and migration inhibition of cancer cells” , Journal of Biomaterials Science, 2020, 31, 1604-1621, DOI: 10.1080/09205063.2020.1764191. Qing You, Kaiyue Zhang, Jingyi Liu, Changliang Liu, Huayi Wang, Mengting Wang, Siyuan Ye, Houqian Gao, Letian Lv, Chen Wang, Ling Zhu*, Yanlian Yang*, “Persistent Regulation of Tumor Hypoxia Microenvironment via a Bioinspired Pt-Based Oxygen Nanogenerator for Multimodal Imaging-Guided Synergistic Phototherapy”, Advanced Science, 2020, 7, 1903341, DOI: 10.1002/advs.201903341. Liang Naixin, Liu Lei, Li Ping, Xu Yuan, Hou Yingshuo, Peng Jiaxi, Song Yang, Bing Zhongxing, Wang Yadong, Wang Yanyu, Jia Ziqi, Yang Xiaoying, Li Da, Xu Huihui, Yu Qian, Li Shanqing*, Hu Zhiyuan*, Yang,Yanlian*,“Efficient isolation and quantification of circulating tumor cells in non-small cell lung cancer patients using peptide-functionalized magnetic nanoparticles”, Journal of Thoracic Disease, 2020, 12, 4262-4273, DOI: 10.21037/jtd-20-1026A. Xiangyu Sha, Ping Li, Yonghai Feng, Dan Xia, Xiaohua Tian, Zengkai Wang, Yanlian Yang, Xiaobo Mao*, and Lei Liu*, “Self-Assembled Peptide Nanofibrils Designed to Release Membrane-Lysing Antimicrobial Peptides” ACS Applied Bio Materials, 2020, 3, 6, 3648–3655, DOI: 10.1021/acsabm.0c00281. Zou, Yimin; Tu, Bin; Yu, Lanlan; Zheng, Yongfang; Lin, Yuchen; Luo, Wendi; Yang, Yanlian; Fang, Qiaojun; Wang, Chen, “Peptide conformation and oligomerization characteristics of surface-mediated assemblies revealed by molecular dynamics simulations and scanning tunneling microscopy” Rsc Adv,2019,9,41345-41350 Changliang Liu, Huan Huang, Lilusi Ma, Xiaocui Fang, Chen Wang*, Yanlian Yang,*, “Modulation of β-Amyloid Aggregation by Graphene Quantum Dots”, Royal society open science, 6, 190271,DOI: 10.1098/rsos.190271 Changliang Liu, Zijian Zhao, Houqian Gao, Iman Rostami, Qing You, Xinru Jia, Chen Wang*, Ling Zhu*, Yanlian Yang*,“Enhanced blood-brain-barrier penetrability and tumor-targeting efficiency by peptide-functionalized poly(amidoamine) dendrimer for the therapy of gliomas”, Nanotheranostics, 2019; 3(4): 311-330. doi:10.7150/ntno.38954 Huayi Wang, Dengzhi Jiang, Wenzhe Li, Xiang Xiang, Jun Zhao, Bin Yu, Chen Wang, Zhaohui He*, Ling Zhu*, Yanlian Yang*, “Evaluation of serum extracellular vesicles as noninvasive diagnostic markers of glioma”, Theranostics, 2019, 9(18):5347-5358. doi:10.7150/thno.33114 Yongfang Zheng,Lanlan Yu,Yimin Zou,Yanlian Yang*, Chen Wang* “Steric Dependence of Chirality Effect in Surface-Mediated Peptide Assemblies Identified with Scanning Tunneling Microscopy”, Nano Letters, 2019, 19(8), 5403-5409, DOI: 10.1021/acs.nanolett.9b01904 Huayi Wang, Kelin Chen, Zhijun Yang, Wenzhe Li, Chen Wang, Guojun Zhang*, Ling Zhu*, Pinan Liu*, Yanlian Yang*,“Diagnosis of Invasive Nonfunctional Pituitary Adenomas by Serum Extracellular Vesicles” Analytical Chemistry, 2019, 91(15), 9580-9589, DOI: 10.1021/acs.analchem.9b00914 Houqian Gao, Zijian Zhao, Zhaohui He, Huayi Wang, Mingzhu Liu, Zhiyuan Hu, Oumei Cheng*, Yanlian Yang*, Ling Zhu*, “Detection of Parkinson’s Disease through the Peptoid Recognizing α-Synuclein in Serum”ACS Chemical Neuroscience, 2019, 10, 3, 1204-1208, DOI: 10.1021/acschemneuro.8b00540

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