Doyle, Michael P. - University of Texas at San Antonio

个人简介

Education Postdoctoral Associate and Instructor, University of Illinois at Chicago Circle, Chicago, Illinois (1968) — Postdoctoral advisor: Jan Rocek Ph.D., Iowa State University, Ames, Iowa (1968) — Thesis advisor: Walter S. Trahanovsky B.S., College of St. Thomas, St. Paul, Minnesota (1964) Employment 2015-present - University of Texas at San Antonio 2003-2014 - University of Maryland, College Park 1997-2003 - University of Arizona 1997-2002 - Research Corporation 1984-1997 - Trinity University, San Antonio, Texas 1968-1984 - Hope College, Holland, Michigan

研究领域

Asymmetric Lewis Acid Catalysis Bioorganic Chemistry of Arenediazonium Salts Bioinorganic Chemistry of Nitrogen Oxides and Nitrosyls Carbocation Chemistry Carbon-Hydrogen Insertion Catalytic Asymmetric Cycloaddition Catalytic Enantioselective Hetero-Diels-Alder Reactions Catalytic Hydroformylation Catalytic Hydrosilylation and Silylcarbonylation Catalytic Oxidation Processes Chemistry of Diazo Compounds Cyclopropane Chemistry Design and Development of Chiral Catalysts Dirhodium(III) Materials Enantioselective Syntheses Formation and Reactions of Diazonium Ions Gold Catalysed Reactions Highly Enantioselective Catalytic Reactions Macrolide Formation in Catalytic Metal Carbene Reactions Mechanisms for Catalysis Metal Carbene Chemistry Organosilane Reductions Metal Carbene [3+n] Reactions Selective Chemical Oxidations Ylide Formation/Reactions

近期论文

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Kuiyong Dong, Haifeng Zheng, Yongliang Su, Ahmad. Humeidi, Hadi Arman, Xinfang Xu,* and Michael P. Doyle* Catalyst-Directed Divergent Catalytic Approaches to Expand Structural and Functional Scaffold Diversity via Metallo-Enolcarbene Intermediates. ACS Catal. 2021, accepted. Kuiyong Dong, Ahmad Humeidi, Wendell Griffith, Hadi Arman, Xinfang Xu,* Michael P. Doyle* A General Methodology to Highly Functionalized Pyrroles by Ag(I)-Catalyzed Transformations of Imino Ethers. Angew. Chem. Int. Ed. 2021, accepted. Zheng, H.; Wang, R.; Wang, K.; Wherritt, D.; Arman, H.; Doyle, M. P. “Formal [4+4]-, [4+3]-, and [4+2]-Cycloaddition Reactions of Donor-Acceptor Cyclobutenes, Cyclopropenes and Siloxyalkynes Induced by Brønsted Acid Catalysis” Chem. Sci. 2021, 12, DOI: 10.1039/D1SC00158B De Angelis, L.; Crawford, A. M.; Su, Y.-L.; Wherritt, D.; Arman, H.; Doyle, M. P. “Catalyst-Free Formation of Nitrile Oxides and Their Further Transformations to Diverse Heterocycles” Org. Lett. 2021, 23, 925-929. DOI: 10.1021/acs.orglett.0c04130 Marichev, K. O.; Wang, K.; Greco, N.; Dong, K.; Chen, J.; Lei, J.; Doyle, M. P. Strain-Induced Nucleophilic Ring Opening of Donor-Acceptor Cyclopropenes for Synthesis of Monosubstituted Succinic Acid Derivatives. Chem. Eur. J. 2021, 27, 340-347. DOI: 10.1002/chem.202003427 Su, Y.-L.; Tram, L.; Wherritt, D.; Arman, H.; Griffith, W. P.; Doyle, M. P.* α-Amino Radical-Mediated Diverse Difunctionalization of Alkenes: Construction of C-C, C-N and C-S Bonds. ACS Catal. 2020, 10, 13682−13687. DOI: 10.1021/acscatal.0c04243 Su, Y.-L.;† Liu, G.-X.;† Liu, J.-W.; Tram, L.; Qiu, H.;* Doyle, M. P.* Radical-Mediated Strategies for the Functionalization of Alkenes with Diazo Compounds. J. Am. Chem. Soc. 2020, 142, 13846-13855. DOI: doi.org/10.1021/jacs.0c05183 Dong, K.; Xu, X.; Doyle, M. P. “Copper(I)-catalyzed highly enantioselective [3+3]-cycloaddition of γ-alkyl enoldiazoacetates with nitrones” Org. Chem. Front. 2020, 7, 1653 –1657. DOI: 10.1039/D0QO00539H Wang, R.; Marichev, K. O.; Dong, K.; Jensen, J. A.; Doyle, M. P. Chiral 3‑Acylglutaric Acid Derivatives from Strain-Induced Nucleophilic Retro-Claisen Ring-Opening Reactions. J. Org. Chem. 2020, 85, 9475–9490. DOI: 10.1021/acs.joc.0c01176 Zheng, H.; Dong, K.; Wherritt, D.; Arman, H.; Doyle, M. P. “Brønsted Acid Catalyzed Friedel-Crafts-type Coupling and Dedinitrogenation Reactions of Vinyldiazo Compounds” Angew. Chem. Int. Ed. 2020, 59, 13613–13617. DOI: 10.1002/ange.202004328 Su, Y.-L.; De Angelis, L.; Tram, L.; Yu, Y.; Doyle, M. P. “Catalytic Oxidative Cleavage Reactions of Arylalkenes by tert-Butyl Hydroperoxide – A Mechanistic Assessment” J. Org. Chem. 2020, 85, 5, 3728–3741. DOI: 10.1021/acs.joc.9b03346 Marichev, K. O.; Dong, K.; Massey, L. A.; Deng, Y.; De Angelis, L.; Wang, K.; Arman, H.; Doyle, M. P. “Chiral donor−acceptor azetines as powerful reactants for synthesis of amino acid derivatives” Nature Commun. 2019, 10, 5328. DOI: 10.1038/s41467-019-13326-8. Neff, R. K., Su, Y.-L., Liu, S., Rosado, M., Zhang, X., Doyle, M. P. “Generation of Halomethyl Radicals by Halogen Atom Abstraction and Their Addition Reactions with Alkenes” J. Am. Chem. Soc. 2019, 141, 16443–16450. DOI: 10.1021/jacs.9b05921 Marichev, K. O.; Wang, K.; Dong, K.; Greco, N.; Massey, L. A.; Deng, Y.; Arman, H.; Doyle, M. P. “ Synthesis of Chiral Tetrasubstituted Azetidines from Donor-Acceptor Azetines via Asymmetric Copper(I)-Catalyzed Imido-Ylide [3+1]-Cycloaddition with Metallo-Enolcarbenes” Angew. Chem. Int. Ed. 2019, 58, 16188–16192. DOI: 10.1002/anie.201909929. Su, Y.-L.; De Angelis, L.; Doyle, M. P. “Discussion Addendum for: Allylic Oxidation Catalyzed by Dirhodium(II) Tetrakis[e-caprolactamate] of tert-Butyldimethylsilyl-protected trans-Dehydroandrosterone” Org. Synth. 2019, 96, 300-311. DOI: 10.15227/orgsyn.096.0300 Dong, K.; Marichev, K. O.; Doyle, M. P. “The Role of Donor-Acceptor Cyclopropenes in Metal Carbene Reactions. Conversion of E-Substituted Enoldiazoacetates to Z-Substituted Metallo-Enolcarbenes” Organometallics 2019, 38, 4043–4050. DOI: 10.1021/acs.organomet.9b00427 Zheng, H.; Doyle, M. P. “Catalytic Desymmetric Cycloaddition of Diaziridines with Metalloenolcarbenes. The Role of Donor-Acceptor Cyclopropenes” Angew. Chem. Int. Ed. 2019, 58, 10343-10346. DOI: 10.1002/anie.201906754 Dong, K.; Marichev, K. O.; Xu, X.; Doyle, M. P. “High Stereocontrol in the Preparation of Silyl-Protected γ-Substituted Enoldiazoacetates” Synlett 2019, 30, 1457-1461. DOI: 10.1055/s-0037-1611865 Marichev, K. O.; Doyle, M. P. “Catalytic asymmetric cycloaddition reactions of enoldiazo compounds” Org. & Biomol. Chem. 2019, 17, 4183 – 4195. DOI: 10.1039/C9OB00478E Adly, F. G.; Marichev, K. O.; Jensen, J. A.; Arman, H.; Doyle, M. P. “Enoldiazosulfones for Highly Enantioselective [3+3]-Cycloaddition Reactions with Nitrones Catalyzed by Copper(I) with Chiral BOX Ligands” Org. Lett. 2019, 21, 40 – 44. DOI: 10.1021/acs.orglett.8b03421