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个人简介

2002-至今,教授,南京大学生命科学学院 2000-2002,副教授, 南京大学生命科学学院 1997-2000,访问学者,新加坡国立大学

研究领域

药物递送系统 组织工程与再生医学 炎症性疾病的调控机制 纳米生物医学

近期论文

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1.Zhang, Z; Wang, C;Zha, Y; Hu, W; Gao, Z;Zang, Y; Chen, J; Zhang, J*; Dong, L. Corona-directed nucleic acid delivery into hepatic stellate cells for liver fibrosis therapy. ACS Nano; 9:2405-19;2015. 2.Huang, Z.; Shi, T.; Zhou, Q.; Shi, S.; Zhao, R.; Shi, H.; Dong, L.; Zhang, C.; Zeng, K.; Chen, J.; Zhang, J*. miR-141 Regulates colonic leukocytic trafficking by targeting CXCL12beta during murine colitis and human Crohn's disease. Gut; 63:1247-57; 2014. 3. Tu, X; Zhang, H; Zhang, J; Zhao, S; Zheng, X; Zhang, Z; Zhu, J; Chen, J; Dong, Lei;Zang, Y;Zhang, J*. microRNA-101 suppresses liver fibrosis by targeting the TGFβ signalling pathway. Journal of Pathology; 234: 46-59, 2014. 4. Zuo, L.; Huang, Z.; Dong, L.; Xu, L.; Zhu, Y.; Zeng, K.; Zhang, C.; Chen, J.; Zhang, J*. Targeting delivery of anti-TNFalpha oligonucleotide into activated colonic macrophages protects against experimental colitis. Gut 59:470-479; 2010. 5. Chen, X.; Ba, Y.; Ma, L.; Cai, X.; Yin, Y.; Wang, K.; Guo, J.; Zhang, Y.; Chen, J.; Guo, X.; Li, Q.; Li, X.; Wang, W.; Wang, J.; Jiang, X.; Xiang, Y.; Xu, C.; Zheng, P.; Zhang, J*.; Li, R.; Zhang, H.; Shang, X.; Gong, T.; Ning, G.; Zen, K.; Zhang, C. Y. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Research 18:997-1006; 2008. 6. Yang, C.; Wang, C.; Chen, X.; Chen, S.; Zhang, Y.; Zhi, F.; Wang, J.; Li, L.; Zhou, X.; Li, N.; Pan, H.; Zhang, J.*; Zen, K.; Zhang, C. Y.; Zhang, C. Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas. International Journal of Cancer 132:116-127; 2013. 7. Chen, X.; Liang, H.; Zhang, J.*; Zen, K.; Zhang, C. Y. Secreted microRNAs: a new form of intercellular communication. Trends in Cell Biology 22:125-132; 2012. 8. Huang, Z.; Zhang, Z.; Jiang, Y.; Zhang, D.; Chen, J.; Dong, L.; Zhang, J*. Targeted delivery of oligonucleotides into tumor-associated macrophages for cancer immunotherapy. Journal of Controlled Release 158:286-292; 2012. 9. Zhang, L.; Hou, D.; Chen, X.; Li, D.; Zhu, L.; Zhang, Y.; Li, J.; Bian, Z.; Liang, X.; Cai, X.; Yin, Y.; Wang, C.; Zhang, T.; Zhu, D.; Zhang, D.; Xu, J.; Chen, Q.; Ba, Y.; Liu, J.; Wang, Q.; Chen, J.; Wang, J.; Wang, M.; Zhang, Q.; Zhang, J*.; Zen, K.; Zhang, C. Y. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Research 22:107-126; 2012. 10. Chen, X.; Hu, Z.; Wang, W.; Ba, Y.; Ma, L.; Zhang, C.; Wang, C.; Ren, Z.; Zhao, Y.; Wu, S.; Zhuang, R.; Zhang, Y.; Hu, H.; Liu, C.; Xu, L.; Wang, J.; Shen, H.; Zhang, J*.; Zen, K.; Zhang, C. Y. Identification of ten serum microRNAs from a genome-wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis. International Journal of Cancer 130:1620-1628; 2012. 11. Wang, C.; Yang, C.; Chen, X.; Yao, B.; Zhu, C.; Li, L.; Wang, J.; Li, X.; Shao, Y.; Liu, Y.; Ji, J.; Zhang, J.*; Zen, K.; Zhang, C. Y.; Zhang, C. Altered profile of seminal plasma microRNAs in the molecular diagnosis of male infertility. Clinical Chemistry 57:1722-1731; 2011. 12. Huang, Z.; Zuo, L.; Zhang, Z.; Liu, J.; Chen, J.; Dong, L.; Zhang, J*. 3,3'-Diindolylmethane decreases VCAM-1 expression and alleviates experimental colitis via a BRCA1-dependent antioxidant pathway. Free Radical Biology & Medicine 50:228-236; 2011. 13. Dong, L.; Xia, S.; Gao, F.; Zhang, D.; Chen, J.; Zhang, J*. 3,3'-Diindolylmethane attenuates experimental arthritis and osteoclastogenesis. Biochemical pharmacology 79:715-721; 2010. 14. Zhang, Y.; Liu, D.; Chen, X.; Li, J.; Li, L.; Bian, Z.; Sun, F.; Lu, J.; Yin, Y.; Cai, X.; Sun, Q.; Wang, K.; Ba, Y.; Wang, Q.; Wang, D.; Yang, J.; Liu, P.; Xu, T.; Yan, Q.; Zhang, J*.; Zen, K.; Zhang, C. Y. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Molecular cell 39:133-144; 2010 15. Zhang, J; Hong, H. Selective Fluorescent Activation for Bioimaging the Expression of Nitric Oxide in Cellular and in vivo Systems, Method in Molecular Biology: Nitric Oxide, 57-71. ISBN: 978-1-61737-964-2 16. Zhang, J.; Huang, Z.; Dong, L. Improving the Tumor-Specific Delivery of Doxorubicin in Primary Liver Cancer. Liver Tumors, 187-200. ISBN: 978-953-51-0036-2 17. Zhang, J.; Huang, Z. Engineering Gene-Activated Matrices for the Repair of Articular Cartilage Defect. Engineering in Translational Medicine, 183-200. ISBN:978-1-4471-4372-7

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