李尔广 - 南京大学 - 医药生物技术国家重点实验室

个人简介

2007.10-至今，教授，南京大学医学院 2002.04-2008.06，Assistant Professor and Principal Investigator，斯可瑞普施研究所 1998.12-2002.04，斯可瑞普施研究生Senior Research Associate，免疫学

研究领域

病原生物感染小分子化合物及功能

近期论文

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Guo X, Liu T, Shi H, Hou Y, Tan RX and Erguang Li*. NLRC5 induction regulates MHC II expression during RSV infection of airway epithelial cells. J Virol, 2015 (in press). Lad, S.P., J. Li, J. da Silva Correia, Q. Pan, S. Gadwal, R.J. Ulevitch, and Erguang Li*. Cleavage of p65/RelA of the NF-κB pathway by Chlamydia. Proc Natl Acad Sci USA. 104:2933-2938, 2007. Lad, S.P., G. Yang, D.A. Scott, G. Wang, P. Nair, J. Mathison, V.S. Reddy, and Erguang Li*. Chlamydial CT441 Is a PDZ Domain-Containing Tail-Specific Protease That Interferes with the NF-êB Pathway of Immune Response. J. Bacteriology. 189:6619-6625, 2007. Lad SP, Fukuda EY, Li J, de la Maza LM and Erguang Li*. Up-regulation of the JAK/STAT1 signal pathway during Chlamydia trachomatis infection. J Immunology. 174: 7186-93, 2005. Xie J, Wang JJ, Li R, Dai Q, Yong YH, Bing Zong, Yunxia Xu, Erguang Li*, Albert Ferro*, Biao Xu*. Long-term syndecan-4 overexpression preserves cardiac function through neovascularization and inhibition of inflammation in a rat model of myocardial infarction. J. Mol and Cell Cardiology 53：250-258, 2012. Fukuda EY, Lad SP, Mikolon DP, Iacobelli-Martinez M and Erguang Li*. Upregulation of Prostaglandin Biosynthesis Attributes to IL-8 Production During Chlamydia Trachomatis Infection of Cervical Epithelial Cells. Infection and Immunity. 73:4017-24, 2005. Li, J., S. Lad, G. Yang, Y. Luo, M. Iacobelli-Martinez, F.J. Primus, R.A. Reisfeld, and Erguang Li*. Adenovirus Fiber Shaft Contains a Trimerization Element That Supports Peptide Fusion for Targeted Gene Delivery. J. Virol. 80:12324-12331, 2006. Li Erguang, Stupack DG, Bokoch GM and GR Nemerow. Adenovirus endocytosis requires reorganization of the actin cytoskeleton mediated by Rho family GTPases. J. Virol. 72:8806-12, 1998. Li Erguang, Stupack DG, Klemke R, Cheresh DA and GR Nemerow. Adenovirus endocytosis via av integrins requires phosphoinositide-3-OH kinase. J. Virol. 72:2055-61, 1998. Li Erguang, Stupack DG, Brown SL, Klemke R, Schlaepfer DD and GR Nemerow. Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry. J. Biol. Chem. 275:14729-35, 2000. Li Erguang, Brown SL, Stupack DG, Puente X, Cheresh DA and GR Nemerow. αvβ1 integrin as a co-receptor for adenovirus infection. J. Virol. 75:5405-9, 2001. Li Erguang, Brown SL, von Seggern DJ, Brown GB and GR Nemerow. Signaling antibodies complexed with adenovirus circumvent CAR and integrin interactions and improve gene delivery. Gene Ther. 7, 1593-9, 2000. Qiao H, Chen X, Wang J, Zhao G, Hou Y, Ge H, RX Tan*, and Erguang Li*. Antitumor effect of naturally occurring oligomeric resveratrol derivatives. FASEB J. 27, 4561-4571, 2013. Zhang W, Qiao H, Lv Y, Wang J, Chen X, Hou Y, RX Tan*, Erguang Li*. Apigenin inhibits enterovirus-71 infection by disrupting viral RNA association with trans-acting factors. PLoS One, 9:e110429, 2014. Zhu, H.R., Z.Y. Wang, X.L. Zhu, X.X. Wu, Erguang Li*, and Y. Xu*. Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke. Neuropharmacology. 59:70-76, 2010. Chen X, Wang Z, Yang Z, Wang J, Tan R-X and Erguang Li*. Houttuynia cordata blocks HSV-2 infection through inhibition of NF-kB activation. Antiviral Res 92:341-345, 2011. Wang J, Guo X, Yang Z, RX Tan, Chen X*, and Erguang Li*. Fungal metabolite myriocin promotes human herpes simplex virus-2 infection. Life Sci. 120:31-8, 2015. Chen XQ, Qiao HS, Liu X, Yang ZY, Xu LF, Xu YX, Ge HM, RX Tan* and Erguang Li*. Inhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation. Antiviral Res 95:30-36, 2012. Wang J, Chen X, Wang W, Zhang Y, Yang Z, Jin Y, Ge H.M, Li Erguang* and G Yang*. Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease, J. Ethnopharmacology, 147, 114-121, 2013. Chen X, Wang C, Xu L, Chen XS, Wang W, Yang G, RX Tan, Li Erguang* and Y Jin*. A Laboratory Evaluation of Medicinal Herbs Used in China for the Treatment of Hand, Foot, and Mouth Disease, Evidence-Based Complementary Alternative Med, ID504563 (doi: 10.1155/2013/504563), 2013.