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1. Jia Liu#, Shan Jiang#, Yue Zhao#, et al., Bin Xue*, Chao-Jun Li*. Geranylgeranyl diphosphate synthase(GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions. J Pathol. 2018; 246(3):277-288. (Commentary by Fullerton MD. Does prenylationpredict progression in NAFLD? J Pathol. 2018; Oct 30)
2. Zhong Chen, et al., Chao-Jun Li*. Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart. Cardiovasc Res. 2018;114(7):965-978. (Commentary by Helen M. Phillips. Protein geranygeranylation: a possible new player in congenital heart defects. Cardiovasc Res. 2018;114:922-924)
3. Jing Wu*, Wei-Wei Tao*, Dan-Yang Chong, Shan-Shan Lai, Chuang Wang, Qi Liu, Tong-Yu Zhang, Bin Xue#, Chao-Jun Li#. Early growth response-1 negative feedback regulates postprandial insulin sensitivity via activating PTP1B expression. FASEB J. 2018, 32(8): 4370-4379
4. Chen Jiang#, Fan Diao#, et al., Chao-Jun Li*. GGPP-mediated protein geranylgeranylation in oocyte is essential for the establishment of oocyte- granulosa cell communication and primary-secondary follicle transition in mouse ovary. PLoS Genetics, 2017, 13(1): e1006535.
5. Fan Diao#, Chen Jiang#, Xiu-Xing Wang, Rui-Lou Zhu, Qiang Wang, Bing Yao* , Chao-Jun Li*. Alteration of protein prenylation promotes spermatogonial differentiation and exhausts spermatogonial stem cells in newborn mice. Scientific Reports, 2016, 6:28917|DOI: 10.1038/srep28917
6. Wen-Jun Jia#, Shan Jiang#, Qiao-Li Tang, Di Shen, Bin Xue, Wen Ning*, Chao-Jun Li*. GGPPS (Geranylgeranyl diphosphate synthase) modulates fetal lung branching morphogenesis possibly through controlling K-Ras prenylation. Am J Pathol, 2016. 186(6):1454-1465
7. Shan-Shan Lai, Dan-Dan Zhao, Peng Cao, Ke Lu, Ou-Yang Luo, Wei-Bo Chen, Jia Liu, En-Ze Jiang, Zi-Han Yu, Gina Lee, Jing Li, De-Cai Yu, Xiao-Jun Xu, Min-Sheng Zhu, Xiang Gao*, Chao-Jun Li*, Bin Xue* PP2Acα Positively Regulates Mice Liver Regeneration Termination through AKT/GSK3β/Cyclin D1 Pathway. J Hepatology 2016, 64(2):352-360
8. Shan Jiang*, Di Shen*, Ning Shen, Xiao Han, Bin Xue*, and Chao-Jun Li*. GGPPS mediated Rab27A geranylgeranylation regulates β-cell dysfunction during type 2 diabetes development via affecting insulin granule docked pool formation. J Path, 2016; 238: 109–119.(Commentary by Kowluru A. A lack of "glue" misplaces Rab27A to cause islet dysfunction in diabetes. J Pathol. 2015, doi: 10.1002/path.4671. )
9. Weiwei Tao, Jing Wu, Qian Zhang, Shan-Shan Lai, Shan Jiang, Chen Jiang, Ying Xu, Bin Xue, Jie Du & Chao-Jun Li.EGR1 regulates hepatic clock gene amplitude by activating Per1 transcription. Scientific Reports, 2015; 5:15212 DOI: 10.1038/srep15212
10. Weiwei Tao, Jing Wu, Bing-Xian Xie, Yuan-Yuan Zhao, Ning Shen, Shan Jiang, Xiu-Xing Wang, Na Xu, Chen Jiang, Shuai Chen, Xiang Gao, Bin Xue, and Chao-Jun Li. Lipid-induced Muscle Insulin Resistance Is Mediated by GGPPS via Modulation of the RhoA/Rho Kinase Signaling Pathway. J Biol. Chem, 2015; 290(33):20086–20097
11. Na Xu, Shan Guan, Zhong Chen, Yang Yu, Jun Xie, Fei-Yan Pan, Ning-Wei Zhao, Li Liu, Zhong-Zhou Yang, Xiang Gao, Biao Xu, Chao-Jun Li*. The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb/mTORC1 signaling and leads to chronic heart failure. J Pathol. 2015; 235: 672–685. (Cover story)
12. Ning Shen#, Shan Jiang#, Jia-Ming Lu, Xiao Yu, Shan-Shan Lai, Jing-Zi Zhang, Jin-Long Zhang, Wei-Wei Tao, Xiu-Xing Wang, Na Xu, Bin Xue*, Chao-Jun Li*. The constitutive activation of Egr-1/C/EBPa mediates the development of type 2 diabetes mellitus by enhancing hepatic gluconeogenesis. Am J Pathol. 2015, 185(2): 513-523.
13. Shanshan Lai，Jun Yuan，Dandan Zhao，Ning Shen，Weibo Chen，Yao Ding，Decai Yu, Jing Li, Feiyan Pan, Minsheng Zhu, Chao-Jun Li*, Bin Xue*. Regulation of Mice Liver Regeneration by Early Growth Response-1 through the GGPPS/RAS/MAPK Pathway. Int J Biochem Cell Biol, 2015, 64:147-154.
14. Wei-Bo Chen, Shan-Shan Lai, De-Cai Yu, Jia Liu, Shan Jiang, Dan-Dan Zhao, Yi-Tao Ding*, Chao-Jun Li*, Bin Xue*. GGPPS deficiency aggravates CCl4-induced liver injury by inducing hepatocyte apoptosis. FEBS Letters 2015, 589(10):1119-1126.
15. Yu De-Cai, Liu Jia, Chen Jun, Shao Jiao-jiao, Shen Xiao,, Xia Hong-Guang, Li Chao-Jun，Xue, Bin*，Ding, Yi-Tao*. GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis. BMC Cancer, 2014, 14: 248-256.
16. Dai Gu, Qian Yan, Chen Jie, Meng Fan-Li, Pan Fei-Yan, Shen Wei-Gan, Zhang Sheng-Zhou, Xue Bin, Li Chao-Jun. Calmodulin activation of polo-like kinase 1 is required during mitotic entry, Biochemistry and Cell Biology, 2013, 91(5):287-294.
17. Tao Weiwei, Shi Jun-Feng, hang Qian, Xue Bin,Sun Yu-Jie, Li Chao-Jun. Egr-1 enhances drug resistance of breast cancer by modulating MDR1 expression in a GGPPS-independent manner. Biomedicine & Pharmacotherapy 2013,67(3):197-202.
18. Yunxia Zhu, Ai Ma, Hongxiu Zhang, Chaojun Li. PPARc Activation Attenuates Glycated-Serum Induced Pancreatic Beta-Cell Dysfunction through Enhancing Pdx1 and Mafa Protein Stability. PLOS One. 2013.8(2): e56386
19. Xiu-Xing Wang, Pu Ying, Fan Diao, Qiang Wang, Dan Ye, Chen Jiang, Ning Shen, Na Xu, Wei-Bo Chen, Shan-Shan Lai, Shan Jiang, Xiao-Li Miao, Jin Feng, Wei-Wei Tao, Bing Yao, Zhi-Peng Xu, Hai-Xiang Sun, Jian-Min Li, Jia-Hao Sha, Xing-Xu Huang, Bin Xue, Hong Tang, Xiang Gao, Chao-Jun Li. The protein prenylation alteration in Sertoli cells is associated with adult infertility resulted from childhood Mumps infection. J Exp Med. 2013, 210(8):1559-1574.
20. Ning Shen#, Yue Shao#, Long Qiao, Run-Lin Yang, Bin Xue, Fei-Yan Pan, Hua-Qun Chen*, Chao-Jun Li*. GGPPS, a new egr-1 target gene, reactivates erk1/2 signaling through increasing ras prenylation. Am J Pathol., 2011,179(6):2740-2750.
21. Xiao Yu#, Ning Shen#, Ming-Liang Zhang Fei-Yan Pan, Chen Wang, Wei-Ping Jia, Chang Liu, Qian Gao, Xiang Gao, Bin Xue*, Chao-Jun Li*. Egr-1 enhances insulin resistance by tilting the balance of PI3K/Akt and MAPK signaling in mice. The EMBO J., 2011, 30(18):3754-3765
22. Ning Shen#, Xiao Yu#, Fei-Yan Pan, Xiang Gao, Bin Xue*, Chao-Jun Li*. An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism. J Biol Chem., 2011, 286(16):14508-15.
23. Ning Shen, Tao Gong, Jian-Dong Wang, Fan-Li Meng, Long Qiao, Run-Lin Yang, Bin Xue, Fei-Yan Pan, Xiao-Jun Zhou Hua-Qun Chen, Wen Ning*, Chao-Jun Li*. Cigarette-smoke induced pulmonary inflammatory responses are mediated by egr-1/ggpps/mapk signaling. Am J Pathol., 2011, 178(1):111–119.
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