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De Molinera F, Hulme C (2012) A Van Leusen deprotection-cyclization strategy as a fast entry into two imidazoquinoxaline families. Tetrahedron Lett., 53:5787-5790.
Smith B, Medda F, Gokhale V, Dunckley T, Hulme C (2012) Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's? ACS Chem. Neurosci. DOI: 10.1021/cn300094k.
Medda F, Hulme C (2012) A facile and rapid route for the synthesis of novel 1,5-substituted tetrazole hydantoins and thiohydantoins via a TMSN3-Ugi/RNCX cyclization. Tetrahedron Lett., 53:5593-5596.
Chen YH, Lu PJ, Hulme C, Shaw AY (2012) Synthesis of kojic acid-derived copper-chelating apoptosis inducing agents. Med. Chem. Res. DOI 10.1007/s00044-012-0094-y.
Xu Z, De Moliner F, Cappelli A, Hulme C (2012) Ugi/Aldol sequence: expeditious entry to several families of densely substituted nitrogen heterocycles. Angew. Chem. Int. Ed. Engl., 51:8037-8040.
Sells E, Medda F, Chang H, Gokhale V, Hulme C, Meuillet EJ (2012) Abstract 2834: Discovery of a novel class of prostaglandin e2 synthesis inhibitors with anti-tumor activity in colorectal cancer. Cancer Res., 72:1.
Xu Z, Shaw AY, Nichol GS, Cappelli AP, Hulme C (2012) Applications of ortho-phenylisonitrile and ortho-N-Boc aniline for the two-step preparation of novel bis-heterocyclic chemotypes. Mol. Divers., 16:607-612.
Gunawan S, Keck K, Laetsch A, Hulme C (2012) Synthesis of peptidomimetics, d- and e-lactam tetrazoles. Mol. Divers., 16:601-606.
Ayaz, M, De Moliner F, Dietrich J, Hulme C (2012) Applications of isocyanides in IMCRs for the rapid generation of molecular diversity. In "Isocyanide Chemistry"; Nenajdenko, V. Ed. Wiley-VCH: Weinheim, Germany; pp. 335-384.
Xu Z, Ayaz M, Cappelli A, Hulme C (2012) A general one-pot, two-step protocol accessing a range of novel polycyclic heterocycles with high skeletal diversity. ACS Comb. Sci., 14:460-464. [Congrats also on getting the cover!]
Shaw AY, Denning CR, Hulme C (2012) Selenium dioxide-mediated synthesis of a-ketoamides from arylglyoxals and secondary amines. Tetrahedron Lett., 53:4151-4153.
Xu Z, Shaw AY, Dietrich J, Cappelli AP, Nichol G, Hulme C (2012) Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines. Mol. Divers., 16:73-79.
Gunawan S, Ayaz M, De Moliner F, Frett B, Kaiser C, Patrick N, Xu Z, Hulme C (2012) Synthesis of tetrazolo-fused benzodiazepines and benzodiazepinones by a two-step protocol using an Ugi-azide reaction for initial diversity generation. Tetrahedron, 68:5606-5611.
Smith B, Chang HH, Medda F, Gokhale V, Dietrich J, Davis A, Meuillet EJ, Hulme C (2012) Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells. Bioorg. Med. Chem. Lett., 22:3567-3570.
Shaw AY, McLaren JA, Nichol GS, Hulme C (2012) Hydrazine-mediated cyclization of Ugi products to synthesize novel 3-hydroxypyrazoles. Tetrahedron Lett., 53:2592-2594.
Shaw AY, Xu Z, Hulme C (2012) Ugi/Robinson-Gabriel reactions directed toward the synthesis of 2,4,5-trisubstituted oxazoles. Tetrahedron Lett., 53:1998-2000.
Shaw AY, Medda F, Hulme C (2012) Facile and rapid route for the synthesis of novel norstatine analogs via PADAM-cyclization methodology. Tetrahedron Lett., 53:1313-1315.
De Moliner F, Hulme C (2012) Straightforward assembly of phenylimidazoquinoxalines via a one-pot two-step MCR process. Organic Lett., 14:1354-1357.
Gunawan S, Petit J, Hulme C (2012) Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles. ACS Comb. Sci., 14:160-163.
Gunawan S, Nichol G, Hulme C (2012) Concise route to a series of novel 3-(tetrazol-5-yl)quinoxalin-2(1H)-ones. Tetrahedron Lett., 53:1664-1667.
Roberts SA, Martinez-Ariza G, Dietrich J, Hulme C (2012) 2,4-Diphenyl-6-trifluoro-methyl-2,3-dihydro-1H,5H-pyrrolo-[3,4-c]pyrrole-1,3-dione. Acta Crystallogr. Sec. E: Struct. Rep. Online:E68.2:o496-o497.
Ayaz M, Dietrich J, Hulme C (2011) A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations. Tetrahedron Lett., 52:4821-4823.
Dömling A, Hulme C (2011) Editorial in "Special issue on Mini-MCR issue and SCS-09 - Second International Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials." Mol. Divers., 15:1-2.
Gunawan S, Nichol GS, Chappeta S, Dietrich J, Hulme C (2011) Concise preparation of novel tricyclic chemotypes: fused hydantoin-benzodiazepines. Tetrahedron Lett., 51:4689-4692.
Xu ZG, Dietrich J, Shaw AY, Hulme C (2010) Two-step syntheses of fused quinoxaline-benzodiazepines and bis-benzodiazepines. Tetrahedron Lett., 51:4566-4569.
Dietrich J, Hulme C, Hurley LH (2010) The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec®, Nexavar®, and BIRB-796. Bioorg. Med. Chem., 18:5738-5748.
Dietrich J, Kaiser C, Meurice N, Hulme C (2010) Concise two-step solution phase syntheses of four novel dihydroquinazoline scaffolds. Tetrahedron Lett., 51:3951-3955.
Meurice N, Wang L, Lipinski CA, Yang ZB, Hulme C, Loftus JC (2010) Structural conservation in band 4.1, ezrin, radixin, moesin (FERM) domains as a guide to identify inhibitors of the proline-rich tyrosine kinase 2. J. Med. Chem., 53:669-677.
Hulme C, Chappeta S, Dietrich J (2009) A simple, cheap alternative to designer convertible isonitriles' expedited with microwaves. Tetrahedron Lett., 50:4054-4057.
Hulme C, Dietrich J (2009) Emerging molecular diversity from the intra-molecular Ugi reaction: iterative efficiency in medicinal chemistry. Mol. Divers., 13:195-207.
Hulme C, Chappeta S, Griffith C, Lee YS, Dietrich J (2009) An efficient solution phase synthesis of triazadibenzoazulenones: 'designer isonitrile free' methodology enabled by microwaves. Tetrahedron Lett., 50:1939-1942.
Hulme C, Lee YS (2008) Emerging approaches for the syntheses of bicyclic imidazo[1,2-x]-heterocycles. Mol. Divers., 12:1-15.
Hulme C, Maggiora GM (2008) Molecular diversity: from small to large, emerging to enabling. Curr. Opin. Chem. Biol., 12:257-259.
Umkehrer M, Ross G, Jager N, Burdack C, Kolb J, Hu H, Alvini-Gaston M, Hulme C (2007) Expeditious synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition. Tetrahedron Lett., 48:2213-2216.
Masquelin T, Bui H, Brickley B, Stephenson G, Schwerkoske J, Hulme C (2006) Sequential Ugi/Strecker reactions via microwave assisted organic synthesis: novel 3-center-4-component and 3-center-5-component multi-component reactions. Tetrahedron Lett., 47:2989-2991.
Ma V, Bannon AW, Baumgartner J, Hale C, Hsieh F, Hulme C, Rorrer K, Salon J, Van Staden C, Tempest P (2006) Solid-phase synthesis and structure-activity relationships of novel biarylethers as melanin-concentrating hormone receptor-1 antagonists. Bioorg. Med. Chem. Lett., 16:5066-5072.
Salamant W, Hulme C (2006) Unique one step, multicomponent a,β,β-oxidations of carbamates with Willgerodt-like hypervalent iodine reagents - an example of triple C-H bond activation. Tetrahedron Lett., 47:605-609.