刘合宾 - 中国医学科学院苏州系统医学研究所 -

个人简介

Qualifications Ph.D., Umeå University, 2005 M.Sc., Immune Biochemistry, Zhejiang University, 1996 B.Sc., Veterinary Medicine, Zhejiang University, 1993 Experience Faculty member, Department of Biological Science, XJTLU, (2012 - Now) Senior Investigator, Department of Pathology, University of Cambridge, (2009 - 2012) Research associate, Department of Pathology, University of Cambridge, (2006 - 2009) Postdoctoral Research associate, Department of Molecular Immunology, Imperial College London, (2005 - 2006) Lecturer, Centre for Disease Control and Preventions of Zhejiang Province, (1996 - 2000)

研究领域

Our laboratory investigates the molecular basis and regulation of T cell activation, focusing on the functional roles of immune adapter proteins e.g. SLP-76 in TCR signalling.

近期论文

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Hebin Liu, Helga Schneider, Asha Recino, Christine Richardson, Martin Goldberg, CE Rudd, (2015), The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells., Molecular Cell, 59 (5), 840-9 (Cover story) Hebin Liu, Thaker Raj, Stagg Loren, Schneider Helga, E John, Ladbury and Christopher E. Rudd, (2013), SLP-76 sterile alpha motif (SAM) and individual H5 alpha helix mediates oligomer formation for microclusters and T-cell activation, J Biol Chem, 288 (41), 29539-49 H Smith, K Schneider, H Kohler, Hebin Liu, Y Lu, C.E. Rudd., (2013), The Chemokine CXCL12 Generates Costimulatory Signals in T Cells to Enhance Phosphorylation and Clustering of the Adaptor Protein SLP-76, Science (Signal), 6 (286), ra65 M.A Purbhoo, Hebin Liu, S Oddos, D Owen, M Neil, S.V. Pageon, P.M. French, C.E. Rudd, and D.M. Davis., (2010), Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse, Science (Signal), 3 (121), ra36 Hebin Liu, M Purbhoo, D Davis, C Rudd, (2010), SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering, Proc Natl Acad Sci USA (107), 10166-1017 Helga Schneider, Xin Smith, Hebin Liu, Georges Bismuth, Christopher Rudd, (2008), CTLA-4 disrupts ZAP-70 microcluster formation with reduced T-cell/APC dwell times and calcium mobilization, Eur J Immunol, 38 (1), 40-7 H Wang, Hebin Liu, Y Lu, M Lovatt, B Wei, Rudd, C. E, (2007), Functional defects of SKAP-55 deficient T-cells identify a regulatory role for the adaptor in LFA-1 adhesion, Mol Cell Biol, 27 (9), 6863-75 Hebin Liu, L Carlsson, T Grundstrom, (2006), Identification of an N-terminal transactivation domain of Runx1 that separates molecular function from global differentiation function, J Biol Chem (281), 25659-69 S Duke-Cohan, H Kang,, Hebin Liu, E Rudd, (2006), Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein, J Biol Chem (281), 13743-50 Hebin Liu, M Holm, XQ Xie, M Wolf-Watz, T Grundstrom, (2004), AML1/Runx1 recruits calcineurin to regulate granulocyte macrophage colony-stimulating factor by Ets1 activation, J Biol Chem (279), 29398-408 Hebin Liu, T Grundstrom, (2002), Calcium regulation of GM-CSF by calmodulin-dependent kinase II phosphorylation of Ets1, Mol Biol Cell (13), 4497-507