李华顺 - 中国医学科学院苏州系统医学研究所 -

个人简介

2013-至今：阿思科力生物科技有限公司董事长、总裁、首席科学家 2013-2015：中科院同济大学附属东方医院干细胞工程转化医学中心主任 2005-2007：美国乔治亚州医学院终身系列助理教授 1999-2005：美国加州大学旧金山分校博士后 1994-1999：美国圣路易斯华盛顿大学博士

研究领域

1、不对称性细胞分裂 2、抗肿瘤药物研发 3、肿瘤免疫细胞治疗

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Li Z, Zhang T, Lin Z, Hou C, Zhang J, Men Y, Li H, Gao J. (2016). Lgl1 Is Required for Olfaction and Development of Olfactory Bulb in Mice. PLoS One. 11(9):e0162126. 2. Zhang, J., Shao, X., Sun, H., Liu, K., Ding, Z., Chen, J., Fang, L., Su, W., Hong, Y., Li, H., Li, H.S. (2016). NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling. Oncotarget 7(38):61036-61053. 3. Lei, R., Zhang, K., Wei, Y., Chen, M., Weinstein, L., S., Hong, Y., Zhu, Y., Li, H., and Li, H.S. (2016). G-protein α-Subunit Gsα is Required for Craniofacial Morphogenesis. Plos One 11(2):e0147535. 4. Shao., X., Liu, Y., Yu, Q., Ding, Z., Qian, W., Zhang, L., Zhang, J., Jiang., N., Gui, L., Xu, Z., Hong, Y., Ma, Y., Wei, Y., Liu, X., Jiang, C., Zhu, M., Li, H., and Li, H.S. (2016) Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b. Cell Research 26:593-612 5. Liu, K., Lei, R., Li, Q., Wang, X., Wu, Q., An, P., Zhang, J., Zhu, M., Xu, Z., Hong, Y., Wang, F., Shen, Y., Li, H., and Li, H.S. (2016) Transferrin receptor controls AMPA receptor trafficking efficiency and synaptic plasticity. Sci Reports Feb 16;6:21019. doi: 10.1038/srep2101. 6. Jiang NW, Wang DJ, Xie YJ, Zhou L, Su LD, Li H, Wang QW, Shen Y. (2016). Downregulation of glutamate transporter EAAT4 by conditional knockout of Rheb1 in cerebellar Purkinje cells. Cerebellum 15:314-21 7. He Q, Yan H, Wo D, Liu J, Liu P, Zhang J, Li L, Zhou B, Ge J, Li H, Liu S, Zhu W. (2016). Wnt3a suppresses Wnt/β-catenin signaling and cancer cell proliferation following serum deprivation. Exp Cell Res 341: 32-41. 8. Shao, X., Liu, K., Fan, Y., Ding, Z., Chen, M., Zhu, M., Weinstein, L.S., Li, H., Li, H. (2015). Gαs Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity. Journal of Genetics and Genomics 11:613-624 9. Liu, K., Lin, Q., Wei, Y., He,R., Shao, X., Ding,Z., Zhang, J., Zhu, M., Lee S. Weinstein, L.S., Hong, Y., Li, HC., and Li, HS. (2015). Gαs regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression. Neurosci. Lett. 597: 97-103 10. Men Y, Zhang A, Li H, Jin Y, Sun X, Li H, Gao J. (2015). LKB1 regulates cerebellar development by controlling Sonic Hedgehog-mediated granule cell precursor proliferation and granule cell migration. Sci Rep. 5: 16232. 11. Men Y, Zhang A, Li H, Zhang T, Jin Y, Li H, Zhang J, Gao J. (2015) LKB1 Is required for the development and maintenance of stereocilia in inner ear hair cells in mice. PLOS One 10(8): 20135841 12. Wang C, Cui T, Feng W, Li H, Hu L. (2015). Role of Numb expression and nuclear translocation in endometrial cancer. Onco Lett 9: 1531-1536 13. Hou, C., Ding, L., Zhang , J.1, Jin , Y., Sun, C., Li, Z., Sun, X., Zhang , T., Zhang, A., Li , H. , Gao, J.. (2014). Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice. Developmental Biology (14)00343-1 14. Sun, C., Zhao, J., Jin, Y., Hou, C., Zong, W., Lu, T., Li H and Gao J. (2014). PTEN regulation of the proliferation and differentiation of auditory progenitors through the PTEN/PI3K/Akt-signaling pathway in mice. Neuroreport. 25:177-83 15. Wang, C., Wang, C., Dong, H., Wu, X.M., Wang , C., Xia, F., Li, G., Jia, X., He, S., Jiang, X., Li H. and Xu, H. (2013). Immune-related GTPase Irgm1 exacerbates experimental auto-immune encephalomyelitis by promoting the disruption of blood-brain barrier and blood-cerebrospinal fluid barrier. Mol. Immunol. 53:43-51 16.Yang, T., Sun, Y., Zhang, F., Zhu, Y., Shi, L., Li, HS*., and Xu, ZH*. (2012). POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration. Cell Reports 2:640-651. * Co-corresponding author. 17. Sun, Y., Fei, T., Yang, T., Zhang, F., Chen, Y., Li, HS. and Xu, ZH. (2010). The suppression of CRMP2 expression BMP-SMAD gradient signaling controls multiple stage of neuronal development. J Biol. Chem. 285: 39039-50. 18. Rasin MR, Gazula VR, Breunig JJ, Kwan KY, Johnson MB, Liu-Chen S, Li HS, Jan LY, Jan YN, Rakic P, Sestan N. (2007). Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci. 10:819-27. 19. Huang, E.J., Li, H-S., Tang, A.A., Luo, E. J., Wiggins, A. K., Neve, R. L., Zhong, W., Jan, L. Y., and Jan, Y. N. (2005). Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev. 19, 138-51 20. Li, H-S., Wang, D, Shen, Q, Schonemann, M. D., Gorski, J.A., Jones, K. R., Temple, S., Jan, L.Y., and Jan, Y.N. (2003). Inactivation of numb and numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40, 1105-18.