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个人简介

2014-至今,苏州系统医学研究所,研究员 2010-至今,美国MD安德森癌症中心,兼职教授 2010-2014年,中山大学,生命科学学院,教授 2003-2010年,美国德州大学,MD安德森癌症中心,助理教授 1998-2003年,加州理工学院,博士后 1998年,美国洛克菲勒大学免疫学和病毒学,博士

研究领域

1. 免疫激活,免疫逃逸在肿瘤免疫治疗中的作用及其调控机制的研究 2. 肿瘤的免疫检查点封锁治疗及其免疫抵抗机制 3. 癌症免疫基因组学和肿瘤微环境中肿瘤免疫相互作用的全局分析 4. F-box和DUB基因在敲除小鼠的IFN信号通路交谈机制中抗病毒和抗肿瘤免疫应答中的体内功能 5. 抗肿瘤药物在小动物水平药效以及免疫学特征检测分析 6. 病毒学和抗感染天然免疫分子机制分析

近期论文

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(1) F. Xiao-Feng Qin, Chengyu Jiang, Taijiao Jiang and Genhong Cheng, New Targets for Controlling Ebola Virus Disease, National Science Review, 2015, 2: 1–3 (2) F. Xiao-Feng Qin, Taijiao Jiang, Genhong Cheng, New Strategies to Fight Against Emerging Viral Infectious Diseases-Systems Medicine for Innate Defense and Development of Broad-Spectrum Antiviral Therapeutics Targeting Host Factors. SCIENTIA SINICA Vitae, 2015, 45:1-9 (3) Xinxin Cia, Hongming Lv, Lidong Wang, Xiaosong Wang, Liping Peng, F. Xiao-Feng Qin*, Genhong Cheng*, The Antioxidative Potential of Farrerol Occurs via the Activation of Nrf2 Mediated HO-1 Signaling in RAW 264.7 Cells, Chemico-Biological Interactions, 2015, 239: 192-199 (4) Limo Chen, John V Heymach, F. Xiao-Feng Qin*, Don L Gibbons*, The Mutually Regulatory Loop of Epithelial–mesenchymal Transition and Immunosuppression in Cancer Progression, OncoImmunology, 2015, 4(5): e1002731 (5) Yongzhi Chen, Shanshan Wang, Zhaohong Yi, Huabin Tian, Roghiyh Aliyari, Yanhua Li, Gang Chen, Ping Liu, Jin Zhong, Xinwen Chen, Peishuang Du, Lishan Su, F. Xiao-Feng Qin*, Hongyu Deng*, Genhong Cheng*, Interferon-inducible Cholesterol-25-hydroxylase Inhibits Hepatitis C Virus Replication via Distinct Mechanisms, Scientific Reports, 2014, 4: 7242 (6) Limo Chen, Don L. Gibbons, John V. Heymach*, Jonathan M. Kurie*, F. Xiao-Feng Qin*, et al. Metastasis is Regulated via MicroRNA-200/ZEB1 Axis Control of Tumour Cell PD-L1 Expression and Intratumoral Immunosuppression, Nature Communications, 2014, 5:5241 (7) F. Xiao-Feng Qin, Dynamic Behavior and Function of Foxp3+ Regulatory T Cells in Tumor Bearing Host, Cellular and Molecular Immunology, 2009, 6(1): 3 (8) Dongsung An#, F. Xiao-Feng Qin#, Vincent C. Auyeung, Sihua Mao, Sam K.P. Kung, David Baltimore, Irvin S.Y. Chen, Optimization of Lentiviral Vector Mediated Expression of Short Hairpin RNAs for Gene Silencing in Primary Human Lymphocytes, Molecular Therapy, 2006, 14: 494-504 (9) F. Xiao-Feng Qin#, Dongsung An#, Irvin S.Y. Chen, David Baltimore, Inhibiting HIV-1 Infection in Human T cells by Lentiviral-mediated Delivery of Small Interfering RNA against CCR5. Proceedings of the National Academy of Sciences, 2003, 100(1): 183-188 (10) F. Xiao-Feng Qin, Stephan Schwers, Wong Yu, Fotini Papavasiliou, Heikyung Suh, Andre Nussenzweig, Klaus Rajewsky, Michel C. Nussenzweig, Secondary V(D)J Recombination in B-1 cells, Nature, 1999, 397(6717): 355-359 (11) F. Xiao-Feng Qin, Amy Reichlin, Yan Luo, Robert G. Roeder, Michel C. Nussenzweig, OCA-B Integrates B Cell Antigen Receptor-, CD40L- and IL 4-mediated Signals for the Germinal Center Pathway of B Cell Development, The EMBO Journal, 1998, 17(17): 5066-5075 (12) F. Xiao-Feng Qin, Yan Luo, Heikyung Suh, Jay Wayne, Ziva Misulovin, Robert G. Roeder and Michel C. Nussenzweig, Transformation by Homeobox Genes can be Mediated by Selective Transcriptional Repression, The EMBO Journal, 1994, 13(24): 5967-5976 (13) F. Xiao-Feng Qin, Loreto Holuigue, Diana M. Horvath, and Nam-Hai Chua, Immediate Early Transcription Activation by Salicylic Acid via the Cauliflower Mosaic Virus as-1 Element, The Plant Cell, 1994, 6(6): 863-874 (14) Lauren Kastner, David Dwyer, F. Xiao-Feng Qin*, Synergistic Effect of IL-6 and IL-4 in Driving Fate Revision of Natural Foxp3+ Regulatory T cells, The Journal of Immunology, 2010, 185(10): 5778-5786 (15) Jun Wei, Omar Duramad, Olivia A. Perng, Steven L. Reiner, Yong-Jun Liu, F. Xiao-Feng Qin*, Antagonistic Nature of T Helper 1/2 Developmental Programs in Opposing Peripheral Induction of Foxp3+ Regulatory T Cells. Proceedings of the National Academy of Sciences, 2007, 104(46): 18169-18174 (16) Yiyue Zhang, Hao Jin, Li Li, F. Xiao-Feng Qin, Zilong Wen, cMyb Regulates Hematopoietic Stem/progenitor Cell Mobilization during Zebrafish Hematopoiesis. Blood, 2011, 118(15): 4093-4101 (17) Tomoki Ito, Shino Hanabuchi, Yi-Hong Wang, Woong Ryeon Park, Kazuhiko Arima, Laura Bover, F. Xiao-Feng Qin, Michel Gilliet, Yong-Jun Liu, Two Functional Subsets of Foxp3+Regulatory T Cells in Human Thymus and Periphery, Immunity, 2008, 28(6): 870-880 (18) Eiji Esashi, Yui-Hsi Wang, Olivia Perng, F. Xiao-Feng Qin, Yong-Jun Liu, Stephanie S. Watowich, The Signal Transducer STAT5 Iinhibits Plasmacytoid Dendritic Cell Development by Suppressing Transcription Factor IRF8, Immunity, 2008, 28(4): 509-520 (19) Kihwan Kim, Omar Duramad, F. Xiao-Feng Qin, Bing Su, MEKK3 is Essential for Lipopolysaccharide-induced Interleukin-6 and Granulocyte-macrophage Colony-stimulating Factor Production in Macrophages, Immunology, 2007, 120(2): 242-250 (20) Jong-Ik Hwang, Iain D.C. Fraser, Sangdun Choi, F. Xiao-Feng Qin, Melvin I. Simon, Analysis of C5a-mediated Chemotaxis by Lentiviral Delivery of Small Interfering RNA, Proceedings of the National Academy of Sciences, 2004, 101(2): 488-493

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