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个人简介

2016-至今 苏州系统医学研究所 研究员 2011-2016 美国加州大学洛杉矶分校 博士后 2006-2011 浙江大学免疫研究所 第二军大学医学免疫学国家重点实验室 医学博士 2002-2006 浙江大学理学院化学系 理学学士

研究领域

1. 宿主抗病毒、抗细菌感染免疫反应的调控 2. 脓毒血症、胰腺炎的致病机制与防治 3. 新型、突发感染性疾病的诊治

近期论文

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Li, D., Wu, R., Guo, W., Xie, L., Qiao, Z., Chen, S., Zhu, J., Huang, C., Huang, J., Chen, B., Qin, Y., Xu, F., and Ma, F. (2019) STING-mediated IFI16 degradation negatively controls type I interferon production. Cell Reports 29, 1249-1260. [PMID: 31665637] Huang, C., Chen, S., Zhang, T., Li, D., Huang, Z., Huang, Z., Qin, Y., Chen, B., Cheng, G., Ma, F.#, and Zhou, M.#. (2019) TLR3 ligand polyI:C prevents acute pancreatitis through IFN-b/IFNAR signaling pathway in a caerulein-induced pancreatitis mouse model. Frontiers in Immunology. 10:980. [PMID: 31130960] Zhang, N.*, Zhang. L.*, Deng, YQ. *, Feng, Y.*, Ma, F.*, Wang, Q., Ye, Q., Han, Y., Sun, X., Zhang, FC., Qi, X., Wang, G., Dai, J., Xia, X., and Qin, CF. (2019) Zika virus infection in Tupaia belangeri causes dermatological manifestations and confers protection against secondary infection. Journal of Virology. pii: JVI.01982-18. [PMID: 30728253] Chen, Q.*, Wu, J.*, Ye, Q.*, Ma, F.*, Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, XF., Qin, X., Zhao, T., Wu, H., Shi, PY., Man, J., and Qin, CF. (2018) Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate. MBio. 9(5). pii: e01683-18. [PMID: 30228241] Wu, T.*, Ma, F.*, Ma, X., Jia, W., Pan, E., Cheng, G., Chen, L., and Sun, C. (2018) Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25-Hydroxycholesterol. Frontiers in Immunology. 9:2686. [PMID: 30524435] Liu, Z., Qin. Q., Wu. C., Li, H., Shou, J., Yang, Y., Gu, M., Ma, C., Lin, W., Zou, Y., Zhang, Y., Ma, F., Sun, J., and Wang, X. (2018) Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. Nature Communications 17, 9(1):2789. [PMID: 30018336] Li, C. *, Deng, Y. Q. *, Wang, S. *, Ma, F. *, Aliyari, R. *, Huang, X. Y. *, Zhang, N. N., Watanabe, M., Dong, H. L., Liu, P., Li, X. F., Ye, Q., Tian, M., Hong, S., Fan, J., Zhao, H., Li, L., Vishlaghi, N., Buth, J. E., Au, C., Liu, Y., Lu, N., Du, P., Qin, F. X., Zhang, B., Gong, D., Dai, X., Sun, R., Novitch, B. G., Xu, Z., Qin, C. F., and Cheng, G. (2017) 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model. Immunity 46, 446-456. [PMID: 28314593]. Ni, X.*, Ru, H.*, Ma, F.*, Zhao, L., Shaw, N., Feng, Y., Ding, W., Gong, W., Wang, Q., Ouyang, S., and Cheng, G. (2016) New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16. Journal of Molecular Cell Biology 8, 51-61. (*, co-first author). [PMID: 26246511]. Ma, F., Li, B., Liu, SY., Iyer, S., Yu, Y., Wu, A., and Cheng, G. (2015). Positive feedback regulation of type I IFN production by the IFN-Inducible DNA sensor cGAS. J Immunol 194, 1545-1554. [PMID: 25609843]. Ma, F., Li, B., Yu, Y., Iyer, S., Sun, M, and Cheng, G. (2015). Positive feedback regulation of type I interferon by the interferon-stimulated gene STING. EMBO Reports 16, 202-212. [PMID: 25572843]. Ma, F., Liu, SY., Razani, B., Arora, N., Li, B., Kagechika, H., Tontonoz, P., Núñez, V., Ricote, M., and Cheng, G. (2014). Retinoid X receptor alpha attenuates host antiviral response by suppressing type I interferon. Nature Communications 5:5494. [PMID: 25417649]. Liu, J., Han, C., Xie, B., Wu, Y., Liu, S., Chen, K., Xia, M., Zhang, Y., Song, L., Li, Z., Zhang, T., Ma,F., Wang, Q., Wang, J., Deng, K., Zhuang, Y., Wu, X., Yu, Y., Xu, T., and Cao, X.. (2014). Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO. Nature Immunology 15, 612-622. [PMID: 24859449]. Lin, L.*, Hou, J. *, Ma, F. *, Wang, P., Liu, X., Li, N., Wang, J., Wang, Q., and Cao, X. (2013). Type I IFN inhibits innate IL-10 production in macrophages through histone deacetylase 11 by downregulating microRNA-145. J Immunol 191, 3896-3904. [PMID: 23980205]. Ma, F., Xu, S., Liu, X., Zhang, Q., Xu, X., Liu, M., Hua, M., Li, N., Yao, H., and Cao, X. (2011). The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-gamma. Nature Immunology 12, 861-869. [PMID: 21785411]. Liu, X., Zhan, Z., Li, D., Xu, L., Ma, F., Zhang, P., Yao, H., and Cao, X. (2011). Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nature Immunology 12, 416-424. [PMID: 21441935]. Ma, F., Liu, X., Li, D., Wang, P., Li, N., Lu, L., and Cao, X. (2010). MicroRNA-466l upregulates IL-10 expression in TLR-triggered macrophages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation. J Immunol 184, 6053-6059. [PMID: 20410487].

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