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个人简介

1984年毕业于武汉大学获学士学位,1990年在美国纽约Albert Einstein医学院分子生物学专业获得博士学位,后曾分别在美国洛克菲洛大学和麻省理工学院做博士后研究。

研究领域

从事感染,免疫,癌症和代谢等多学科的研究。

近期论文

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1.Cheng, G., Cleary, A. M., Ye, Z. S., Hong, D. I., Lederman, S., and Baltimore, D. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science 267:1494-1498, 1995. PMID: 7533327 2.Chin, A. I., Dempsey, P. W., Bruhn, K., Miller, J. F., Xu, Y., and Cheng, G. Involvement of Receptor Interacting Protein 2 in Innate and Adaptive Immune Responses. Nature 416:190-194, 2002. PMID: 11894097 3.Doyle, S. E., Vaidya, S. A., O’Connell, R., Dadgostar, H., Dempsey, P. W., Wu, T. T., Rao, G., Sun, R., Haberland, M. E., Modlin, R. L., Cheng, G. IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program. Immunity 17:251-263, 2002. PMID: 12354379 4.Doyle, S. E., O’Connell, R. M., Miranda, G. A., Vaidya, S. A., Chow, E. K., Liu, P. T., Suzuki, S., Suzuki, N., Modlin, R. L., Yeh, W. -C., Lane, F. T. and Cheng, G. Toll-like Receptors Induce a Phagocytic Gene Program through p38. J Exp Med., 199:81-90. 2004. PMID: 14699082 5.O’Connell, RM, Saha, SK., Vaidya SA, Bruhn, KW., Gustavo A. Miranda, GA., Brian Zarnegar, B., Perry, AK., Nguyen, B., Lane, TF., Taniguchi, T., Miller, JF., and Cheng, G. Type I Interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med., 200:437-445, 2004. PMID: 15302901 6.Oganesyan, G., Saha, SK, Guo, B., He, J., Shahangian, A., Zarnegar B., Perry, AK., Cheng, G. Critical role of TRAF3 in the Toll-like receptor-dependent and independent antiviral response. Nature, 439:208-211, 2006. PMID: 16306936 7.Saha, SK., Pietras, EM., He, JQ., Kang, JR., Liu, SY., Oganesyan, G., Shahangian, A., Zarnegar, B., Shiba TL., and Cheng, G. Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J. 25:3257-3263, 2006 PMID: 16858409 8.He, JQ., Zarnegar, B., Yamazaki, S., Oganesyan, G., Saha, SK., Doyle, S., Dempsey, P., and Cheng, G. Rescue of TRAF3 null mice by p100 NF-κB deficiency. J Exp Med., 203 (11):2413-2418, 2006. PMID: 17015635 9.Chow, EK., Castrillo, A. Shahangian, A., Pei, L., O’Connell, RM., Modlin, RL., Tontonoz, P., and Cheng, G Critical role of IRF3-dependent RXRα repression in hepatotoxicity associated with viral infections. J Exp Med., 203 (12):2589-2602, 2006. PMID: 17074929 10.Zanegar, B., Yamazak S. He JQ, Cheng G. Control of Canonical NF-κB Activation through the NIK-IKK-Complex Pathway. PNAS, 2008 Feb 21; [Epub ahead of print], PMCID: 2265190 11.Guo B, Chang EY, Cheng G. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. Journal of clinical investigation (JCI), 118:1680-1690. 2008, PMCID: 2276397 12.Zarnegar BJ, Wang Y.,, Mahoney DJ, Dempsey PD, Cheung HH, He J, Shiba T, Yang X., Yeh WC, Mak TW, Korneluk RG, and Cheng G. Activation of noncanonical NF-κB requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2, TRAF3 and the kinase NIK Nature Immunology, 2008 Dec;9(12):1371-8. PMCID: 2676931 13.Bahram Razani, Brian Zarnegar, Anders J. Ytterberg, Travis Shiba, Paul Dempsey, Carl F. Ware, Joseph A. Loo, Genhong Cheng Negative Feedback in Non-canonical NF-kB Signaling Modulates NIK Stability Through IKKα-mediated Phosphorylation Science Signaling, May 25;3(123):ra41., 2010, PMCID: 2913610 14.Su-Yang Liu, David Jesse Sanchez, Roghiyh Aliyari, and Genhong Cheng Systematic Identification of Type-I and Type-II Interferon Induced Anti-Viral Factors. PNAS, 2012, Feb 27. [Epub ahead of print], PMID:22371602. 15.Su-Yang Liu, Roghiyh Aliyari, Kelechi Chikere, Guangming Li, Matthew D Marsden, Jennifer K Smith, Olivier Pernet, Haitao Guo, Rebecca Nusbaum, Jerome A Zack; Alexander N Freiberg, Lishan Su, Benhur Lee, and Genhong Cheng Cholesterol-25-Hydroxylase Broadly Inhibits Viral Replication by Production of 25-Hydroxycholesterol. Immunity, 2012 Dec 27. PMID:23273844

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