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个人简介

2018-至今 苏州系统医学研究所 研究员 2017-2018 瑞士洛桑大学路德维格癌症研究中心 课题负责人 2012-2017 瑞士洛桑大学路德维格癌症研究中心 博士后 2004-2011 中国科学院动物研究所 膜生物学国家重点实验室 理学博士

研究领域

主要从事肿瘤免疫学及免疫代谢方面的研究工作,我们将通过靶向CD8 T细胞内信号通路及代谢途径,结合炎性肿瘤微环境的代谢及表观遗传学调控机制研究,期望发现肿瘤免疫治疗的新靶点及策略。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1、Dumauthioz N, Tschumi B, Wenes M, Marti B, Wang H, Franco F, Li W, Lopez-Mejia IC, Fajas L, Ho PC, Donda A, Romero P*, Zhang L*. Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and anti-tumor immunity. Cellular and Molecular Immunology. 2020 Feb 13. doi: 10.1038/s41423-020-0365 2、Wenes M, Romero P, Zhang L. Assessment of memory formation by metabolically engineered antigen-specific CD8 T cells. Methods Enzymol. 2020;631:77-90 3、Duan Q, Zhang H, Zheng J, Zhang L*. Turning cold into hot: firing up the TME. Trends in Cancer, 2020 in press 4、Geller S, Arribat Y, Netzahualcoyotzi C, Lagarrigue S, Carneiro L, Zhang L, Amati F, Lopez- Mejia IC, Pellerin L. Tanycytes Regulate Lipid Homeostasis by Sensing Free Fatty Acids and Signaling to Key Hypothalamic Neuronal Populations via FGF21 Secretion. Cell Metab. 2019 Oct 1;30(4):833-844 5、Martínez-Carreres L, Puyal J, Leal-Esteban LC, Orpinell M, Castillo-Armengol J, Giralt A, Dergai O, Moret C, Barquissau V, Nasrallah A, Pabois A, Zhang L, Romero P, Lopez-Mejia IC, Fajas L. CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival. Cancer Res. 2019 Oct 15;79(20):5245-5259 6、Vannini N, Campos V, Girotra M, Trachsel V, Rojas-Sutterlin S, Tratwal J, Ragusa S, Stefanidis E, Ryu D, Rainer PY, Nikitin G, Giger S, Li TY, Semilietof A, Oggier A, Yersin Y, Tauzin L, Pirinen E, Cheng WC, Ratajczak J, Canto C, Ehrbar M, Sizzano F, Petrova TV, Vanhecke D, Zhang L, Romero P, Nahimana A, Cherix S, Duchosal MA, Ho PC, Deplancke B, Coukos G, Auwerx J, Lutolf MP, Naveiras O. The NAD-booster nicotinamide riboside potently stimulates hematopoiesis through increased mitochondrial clearance. Cell Stem Cell, 2019 Mar 7;24(3):405-418 7、Tschumi BO, Dumauthioz N, Marti B, Zhang L, Lanitis E, Irving M, Schneider P, Mach JP, Coukos G, Romero P, Donda A. CAR T cells are prone to Fas- and DR5 mediated cell death. J Immunother Cancer. 2018 Jul 13;6(1):71. 8、Bantug GR, Fischer M, Grählert J, Balmer ML, Unterstab G, Develioglu L, Steiner R, Zhang L, Costa ASH, Gubser PM, Burgener AV, Sauder U, Löliger J, Belle R, Dimeloe S, Lötscher J, Jauch A, Recher M, Hönger G, Hall MN, Romero P, Frezza C, Hess C. Mitochondria–ER contact sites are immunometabolic hubs that orchestrate the rapid recall response of memory CD8+ T cells. Immunity. 2018 Mar 20;48(3):542-555. 9、Zhang L*, Romero P*. Metabolic control of CD8+ T cell fate decisions and anti-tumor immunity. (Feature review) Trends Mol Med. 2018 Jan;24(1):30-48 10、Lopez-Mejia IC, Lagarrigue S, Giralt A, Martinez-Carreres L, Zanou N, Denechaud PD, Castillo-Armengol J, Chavey C, Orpinell M, Delacuisine B, Nasrallah A, Collodet C, Zhang L, Viollet B, Hardie DG, Fajas L. CDK4 phosphorylates AMPKα2 to inhibit its activity and repress fatty acid oxidation. Molecular Cell, 2017 Oct 19;68(2):336-349. 11、Zhang L, Alena Donda*. aGalCer/CD1d-antibody fusion proteins redirect iNKT cell immunity to solid tumors and promote prolonged therapeutic responses. Front Immunol. 2017 Nov 1;8:1417 12、Lai Q, Giralt A, Le May C, Zhang L, Cariou B, Denechaud PD, Fajas L. E2F1 inhibits circulating cholesterol clearance by regulating PCSK9 expression in the liver. JCI Insight. 2017;2(10):e89729 13、Jandus C, Usatorre AM, Viganò S, Zhang L, Romero P. The Vast Universe of T Cell Diversity: Subsets of Memory Cells and Their Differentiation. Methods Mol Biol. 2017;1514:1-17. 14、Chen H1,#, Zhang L1,#, Wang P1, Su H1, Wang W2, Chu Z1, Zhang L3,4,5, Zhang X2, Zhao Y1. mTORC2 controls Th9 differentiation and airway inflammation. Allergy 2017 Mar 8. doi: 10.1111/all.13152 15、Wang P#, Su H#, Zhang L#, Chen H, Hu X, Yang F, Lv J, Zhang L, Zhao Y. Phosphatase Wip1 controls the development 1 of Th9 cells and allergic airway inflammation. J Allergy Clin Immunol. 2017 Jul 18. pii: S0091-6749(17)31106-5. 16、Liang Z#, Zhang L#, Su H#, Luan R#, Na N, Sun L, Zhao Y, Zhang X, Zhang Q, Li J, Zhang L, Zhao Y. MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance. Autophagy 2018;14(3):505-517 17、Zhang L*, Tschumi BO, Lopez-Mejia IC, Oberle SG, Meyer M, Samson G, Rüegg MA, Hall MN, Fajas L, Zehn D, Mach JP, Donda A, Romero P*. Mammalian target of rapamycin complex 2 controls CD8 T cell memory differentiation in a Foxo1- dependent manner. Cell reports, 2016 Feb 9;14(5):1206-17; 18、Scholz G, Jandus C, Zhang L, Grandclément C, Lopez-Mejia IC, Soneson C, Delorenzi M, Fajas L, Held W, Dormond O, Romero P. Modulation of mTOR signaling triggers the formation of stem cell-like memory T cells. EBiomedicine, 2016 Jan 16;4:50-61 19、Lagarrigue S, Lopez-Mejia IC, Denechaud PD, Escoté X, Castillo-Armengol J, Jimenez V, Chavey C, Giralt A, Lai Q, Zhang L, Martinez-Carreres L, Delacuisine B, Annicotte JS, Blanchet E, Huré S, Abella A, Tinahones FJ, Vendrell J, Dubus P, Bosch F, Kahn CR, Fajas L. CDK4 is an essential insulin effector in adipocytes. J Clin Invest. 2016 Jan;126(1):335-48. 20、Corgnac S#, Perret R#, Zhang L, Mach JP, Romero P, Donda A. iNKT/CD1d-antitumor immunotherapy significantly increases the efficacy of therapeutic CpG/peptide-based cancer vaccine. J Immunother Cancer. 2014 Nov 18;2(1):39.

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