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个人简介

本科毕业于厦门大学,并于2012年在加州大学尔湾分校 (University of California, Irvine)获得博士学位。之后加入诺贝尔奖获得者David Baltimore在加州理工学院(California Institute of Technology)的实验室进行博士后研究。

研究领域

长期从事免疫及肿瘤的转化医学研究。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1、Wang. Z, Cheng. G, Li. G †. (2019). TCR Ligand Discovery via T-Scan, Trends Immunol. (in press) (IF 14.188) 2、Frankiw. L, Baltimore. D, Li. G †. (2019). Alternative mRNA splicing in cancer immunotherapy, Nat. Rev. Immunol, 2019 Jul 30. (IF=44.019) 3、Richard. PD, Baltimore. D†, Li. G †. (2019). The cellular immunotherapy revolution: arming the immune system for precision therapy, Trends Immunol, 40 (4): 292-309. (IF 14.188) 4、Li, G. *†, M.T. Bethune*†, S. Wong, A.V. Joglekar, M.T. Leonard, J.K. Wang, J.T. Kim, D. Cheng, S. Peng, J.M. Zaresky, Y. Su, J.R. Heath, A. Ribas, O.N. Witte, and D. Baltimore†. (2019). T cell antigen discovery via trogocytosis. Nat. Methods, 16 (2): 183-190. (IF 26.919) 5、Segaliny, A.*, G. Li*, L. Kong, C. Chen, X. Chen, J. K. Wang, D. Baltimore, G. Wu and W. Zhao. (2018). Functional TCR T cell screening using single-cell Droplet microfluidics. Lab Chip, 18:3733-3749. (IF 5.995) 6、Li, G.†, A.Y. So, R. Sookram, S. Wong, J.K. Wang, Y. Ouyang, P. He, Y. Su, R. Casellas and D. Baltimore†. (2018). Epigenetic silencing of miR-125b is required for normal B cell development. Blood, 131:1920-1930. (IF 15.132) 7、Li, G., C.A. White, T.S. Lam, E.J. Pone, D. Tran, K.L Hayama. Zan, Z. Xu and P. Casali. (2013). Combinatorial H3K9acS10ph histone modification in IgH locus S regions targets 14-3-3 adaptors and AID to specify antibody class switch. Cell Reports, 5: 702-714. (IF 8.032) 8、Li, G., H. Zan, Z. Xu and P. Casali. (2013). Epigenetics of the antibody response. Trends Immunol., 34.460-470. (IF 14.188) 9、Li, G., E.J. Pone, D.C. Tran, P.J. Patel, L. Dao, Z. Xu and P. Casali. (2012). Iron inhibits AID-mediated deoxycytidine deamination and modulates class switch DNA recombination. J. Biol. Chem., 287: 21520-21529. (IF 4.01) 10、Qiu, X.*, G. Li*, G. Wu*, J. Zhu, L. Zhou, P. Chen, A.R. Chamberlin and W-H. Lee. (2009). Synthesis, and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. J. Med. Chem., 52:1757-1767. (IF 6.253) 11、Li, G., J. Fang, H. Chen, J. Luo, Z. Zheng, Y. Shen and Q. Wu. (2007). Negative regulation of transcription co-activator p300 by orphan receptor TR3. Nucleic Acids Res. 35:7348-7359. (IF 11.561) 12、Joglekar A., M. Leonard, J. Jeppson, G. Li , S. Wong, S. Peng, J. Zaretsky, J. Heath, A. Ribas, M. Bethune, D. Baltimore. (2019) T cell antigen discovery via Signaling and Antigen presenting Bifunctional Receptors. Nat. Methods, 16 (2): 191-198. (IF 26.919) 13、Yi, T., L. Zhuang, G. Song, B. Zhang, G. Li, and T. Hu. (2015). Akt signaling is associated with the berberine-induced apoptosis of human gastric cancer cells. Nutrition and Cancer, 67:523-531 (IF 2.261) 14、White, C.A., E.J. Pone, T.S. Lam, C. Tat, G. Li, H. Zan, and P. Casali. (2014). Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses. J. Immunol., 193: 5933-5950. (IF 4.539) 15、Mai, T., E.J. Pone, G. Li, J. Moehlman, Z. Xu and P. Casali. (2013). Induction of activation-induced cytidine deaminase-targeting adaptor 14-3-3γ is mediated by NF-κB-dependent recruitment of CFP1 to the 5'-CpG-3'-rich 14-3-3γ promoter and is sustained by E2A. J. Immunol., 191: 1895-1906. (IF 4.539) 16、Zhu, J., L. Zhou, G. Wu, X. Lin, G. Li, H. Konig, X. Qiu, R. Bhatia, A.R. Chamberlin P. Chen and W-H.Lee. (2013). A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. EMBO Mol. Med. 5:353-365. (IF 10.293) 17、Lam, T.S., L.M. Thomas, E.J. Pone, T. Mai, G. Li, Z. Xu and P. Casali. (2013). Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination. PLOS ONE, 8:e80414. (IF 2.766) 18、Pone, E.J., J. Zhang, T. Mai, C.A. White, G. Li, P. Patel, A. Al-Qahtani, J. Sakakura, H. Zan, Z. Xu and P. Casali. (2012). BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class switch recombination through the non-canonical NF-κB pathway. Nat. Commun. 3:767. (IF 12.353) 19、Zan, H., C.A. White, L. Thomas, T. Mai, G. Li, Z. Xu, J. Zhang and P. Casali. (2012). Rev1 recruits Ung to switch regions and enhances dU glycosylation for immunoglobulin class switch DNA recombination. Cell Reports, 2:1220-1232. (IF 8.032) 20、Chen,H., L. Li, W. Wang, X. Du, Q. Wen, J. He, B. Zhao, G. Li, W. Zhou and Q. Wu. (2012). Prolylisomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis. Oncogene. 31:2876-2887. (IF 6.854)

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