李成文 - 中国医学科学院血液学研究所 -

个人简介

教育 9/1982 - 7/1987同济医科大学获学士学位 9/1990 - 7/1995协和医科大学获博士学位工作 8/1987 - 8/1990医科院血液学研究所住院医生 8/1995 - 9/1996医科院血液学研究所主治医生 10/1996 - 3/1997日本冈山大学医学院访问学者 4/1997 - 12/1998医科院血液学研究所副教授 1/1999 - 1/ 2000日本Tokai医科大学助理研究员 2/2000 – 9/2004北卡罗拉那大学实习研究员 10/2004 - 2/2010北卡罗拉那大学助理研究员 10/2009 - 血液学研究所兼职教授 3/2010 - 北卡罗拉那大学助理教授

近期论文

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1. Li C, Ando K, Kametani Y, Oki M, Hagihara M, Shimamura K, Habu S, Kato S, Hotta T. Reconstitution of functional human B lymphocytes in NOD/SCID mice engrafted with ex vivo expanded CD34(+) cord blood cells. Exp Hematol, 2002 Sep;30(9):1036-43. 2. Rabinowitz JE, Rolling F, Li C, Conrath H, Xiao W, Xiao X, Samulski RJ. Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity. J Virol, 2002 Jan;76(2):791-801. 3. Li C, Samulski RJ. Serotype-specific replicating AAV helper constructs increase recombinant AAV type 2 vector production. Virology, 2005 Apr 25;335(1):10-21. 4. Li C, Bowles DE, van Dyke T, Samulski RJ. Adeno-associated virus vectors: potential applications for cancer gene therapy. Cancer Gene Ther, 2005 Dec;12(12):913-25. 5. Li C, Hirsch M, Asokan A, Zeithaml B, Ma H, Kafri T, Samulski RJ. AAV2 Capsid Specific Cytotoxic T lymphocytes only Eliminate vector transduced Cells Co-expressing the AAV2 Capsid in vivo. J Viol 2007: 81(14):7540-7 6. Chengwen Li, Matt Hirsch, Pam Carter, Aravind Asokan, Xiaohuai Zhou, Zhijian Wu and R. Jude Samulski. A Small Regulatory Element from Chromosome 19 Enhances Liver Specific Gene Expression. Gene Ther. 2009 Jan;16(1):43-51 7. F. Curtis Hewitt, Chengwen Li (first two authors contribute equally), Steven J. Gray, Shelley Cockrell, Michael Washburn, and R. Jude Samulski. Reducing the Risk of AAV Vector Mobiloization with AAV5 Vectors. J Virol. 2009 Apr;83(8):3919-29 8. Chengwen Li, Matt Hirsch, Nina DiPrimio, Aravind Asokan, Kevin Goudy, Roland Tisch and R. Jude Samulski. Cytotoxic T lymphocyte mediated elimination of target cells transduced with engineered AAV2 vector in vivo. J Virol. 2009 Jul;83(13):6817-24 9. Chengwen Li, Kevin Goudy, Matt Hirsch, Aravind Asokan, Yun Fan, Jeff Alexander, Junjiang Sun, Paul Monahan, David Seiber, Roland Tisch, Jeff Frelinger and R. Jude Samulski. Cellular Immune Response to Cryptic Epitopes During Therapeutic Gene Transfer. PNAS. 2009 Jun 30;106(26):10770-4 10. Asokan A, Conway JC, Phillips JL, Li C, Hegge J, Sinnott R, Yadav S, DiPrimio N, Nam HJ, Agbandje-McKenna M, McPhee S, Wolff J, Samulski RJ. Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle. Nat Biotechnol. 2010 Jan;28(1):79-82.