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个人简介

教育情况 1981.9-1987.7山东医科大学医学系,医学学士 工作简历 1987.8-1995.7中国医学科学院血液学研究所血液病医院实习研究员、助理研究员 1995.8-1999.7美国国立卫生研究院访问学者 1999.9-2005.9中国医学科学院血液学研究所血液病医院,副研究员 2005.9-至今中国医学科学院血液学研究所血液病医院,研究员

研究领域

长期从事白血病发病机理相关基础,研究了多种转录调节因子、癌基因、抑癌基因在白血病中的表达,及其对白血病细胞增殖、分化和凋亡的影响,探索白血病的治疗靶标,研发具有自主知识产权的抗白血病细胞的嵌合性抗原受体T细胞

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Chen S, Li H, Li S, Yu J, Wang M, Xing H, Tang K, Tian Z, Rao Q*, Wang J*. Rac1 GTPase promotes interaction of hematopoietic stem/progenitor cell with niche and participates in leukemia initiation and maintenance in mouse. Stem Cells. 2016 Mar 4. doi: 10.1002/stem.2348. [Epub ahead of print] 2. Na An, Zhongfei Tao, Saisai Li, Haiyan Xing, Kejing Tang, Zheng Tian, Qing Rao, Min Wang* and Jianxiang Wang*, Construction of a new anti-CD19 chimeric antigen receptor and the anti-leukemia function study of the transduced T cells, Oncotarget, 2016, 7(9): 10638-49. 3. Shuying Chen, Haiyan Xing, Shouyun Li, Jing Yu, Huan Li, Shuang Liu, Zheng Tian, Kejing Tang, Qing Rao, Min Wang and Jianxiang Wang*, Up-regulated A20 promotes proliferation, regulates cell cycle progression and induces chemotherapy resistance of acute lymphoblastic leukemia cells, Leukemia Res, 2015, 39: 976–98 4. Jing Yu, ShaoweiQiu, Qiufu Ge, Ying Wang, Hui Wei, DianwuGuo, Shuying Chen, Shuang Liu, Shouyun Li, Haiyan Xing, Qing Rao, Jianxiang Wang* and Min Wang*, A novel SAHA-bendamustine hybrid induces apoptosis of leukemia cells, Oncotarget, 2015, 6(24):20121-31 5. ShaoweiQiu, Min Wang, Jianxiang Wang*, New insight of leukemic stem cell, Stem Cell Transl Invest, 2014; 1: 1-3 6. Yirui Chen#, Shouyun Li#, Chunlin Zhou, Chengwen Li, Kun Ru, Qing Rao, Haiyan Xing, Zheng Tian, Kejing Tang, YingchangMi, Baohong Wang, Min Wang*, and Jianxiang Wang*, TBLR1 fuses to retinoid acid receptor alpha in a variant t(3;17)(q26;q21) translocation of acute promyelocytic leukemia, Blood, 2014, 124(6):936-945 7 Houcai Wang, Jing Yu, Lixia Zhang, YuanyuanXiong, Shuying Chen, Haiyan Xing, Zheng Tian, Kejing Tang, Hui Wei, Qing Rao, Min Wang and Jianxiang Wang*, RPS27a promotes proliferation, regulates cell cycle progression and inhibits apoptosis of leukemia cells, BBRC, 2014, 446: 1204–1210 8. YujiaoJia#, Leiwen Peng#, Qing Rao, Haiyan Xing, Lei Huai, Pei Yu, Yirui Chen, Cuicui Wang, Min Wang, YingchangMi, Jianxiang Wang*, Oncogene iASPP enhances self-renewal of hematopoietic stem cells and facilitates their resistance to chemotherapy and irradiation, FASEB J. , 2014, 28: 2816–2827 9. ShaoweiQiu, YujiaoJia, Haiyan Xing, Tengteng Yu, Jing Yu, Pei Yu, Kejing Tang, Zheng Tian, Huijun Wang, YingchangMi, Qing Rao, Min Wang, Jianxiang Wang*, N-cadherin and Tie2 positive CD34+CD38-CD123+ leukemic stem cell populations can develop acute myeloid leukemia more effectively in NOD/SCID mice, Leukemia Res, 2014, 38: 632–637 10. Ji-Ying Wang#, Pei Yu#, Shuying Chen#, Haiyan Xing, Yirui Chen, Min Wang, Kejing Tang, Zheng Tian, Qing Rao*, Jianxiang Wang*, Activation of Rac1 GTPase promotes leukemia cell chemotherapy resistance, quiescence and niche interaction. MolOncol. 2013, 7: 907-916 11. Shuning Wei, Siping Wang, ShaoweiQiu, Junyuan Qi, YingchangMi, Dong Lin, Chunlin Zhou, Bingcheng Liu, Wei Li, Ying Wang, Min Wang, Jianxiang Wang*, Clinical and laboratory studies of 17 patients with acute myeloid leukemia harboring t(7;11)(p15;p15) translocation, Leukemia Res, 2013, 37(9): 1010-1015 12. Qihui Li, Lei Huai, Cuiping Zhang, Cuicui Wang, YujjaoJia, Yirui Chen, Pei Yu, Houcai Wang, Qing Rao, Min Wang, Jianxiang Wang*, Icaritin induces AML cell apoptosis via the MAPK/ERK and PI3K/AKT signal pathways, Int J Hematol, 2013, 97(5): 617-623 13. Lin Wang, Haiyan Xing, Zheng Tian, Leiwen Peng, Yan Li, Kejing Tang, Qing Rao, Min Wang, Jianxiang Wang*, iASPPsv antagonizes apoptosis induced by chemotherapeuticagents in MCF-7 cells and mouse thymocytes, BiochemBiophys Res Commun, 2012, 424(3): 414-20 14. Lei Huai, Cuicui Wang, Cuiping Zhang, Qihui Li, Yirui Chen, YujiaoJia, Yan Li, Haiyan Xing, Zheng Tian, Qing Rao, Min Wang, Jianxiang Wang*, Metformin induces differentiation in acute promyelocytic leukemia by activating the MEK/ERK signaling pathway, BBRC, 2012, 422(3): 398–404 15. Jiazhuo Liu, Haiyan Xing, Yirui Chen, Lin Wang, Donghai Wang, Qing Rao, Kejing Tang, Zheng Tian, Kan He, Min Wang*, Jianxiang Wang*, PIG7, transactivated by AML1, promotes apoptosis and differentiation of leukemia cells with AML1-ETO fusion gene, Leukemia, 2012, 26: 117–126 16. Yiqun Zhang , Hui Wei, Kejing Tang, Dong Lin, Cuiping Zhang, YingchangMi, Lin Wang, Cuicui Wang, Min Wang, Jianxiang Wang*, Mutation analysis of isocitrate dehydrogenase in acute lymphoblastic leukemia, Genet Test Mol Biomarkers, 2012, 16 (8): 991-995 17. Yiqun Zhang, Hui Wei, Min Wang, Lei Huai, YingchangMi, Yizhi Zhang, Dong Lin, Bingcheng Liu, Wei Li, Chunlin Zhou, Qing Rao, Jianxiang Wang*, Some novel features of IDH1-mutated acute myeloid leukemia revealed in Chinese patients, Leukemia Res, 2011 Oct, 35(10): 1301–1306 18. Qing Rao, Jiying Wang, JihongMeng, Kejing Tang, Yanzhong Wang, Min Wang, Haiyan Xing, Zheng Tian, Jianxiang Wang*, Low-expression of E-cadherin in leukemia cells causes loss of homophilic adhesion and promotes cell growth, Cell Biol. Int., 2011, 35: 945–951

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