个人简介

NSF CAREER Award, 2015 Young Investigator Award of the International Society for Zinc Biology, 2009 Robert A. Welch Professional Development Fellowship, 2006 BASF Endowed Fellowship, University of Texas, 2002 Elio Russo Award, University o

研究领域

Inorganic/Bioinorganic/Chemical Biology/Synthesis/Synthetic Methods Development

Research in the Tomat laboratory focuses on the chemistry and biology of transition metal ions and redox-active species, and addresses open questions regarding their involvement in human health and disease. We are particularly interested in the interplay of biological redox processes and metal complexes.

近期论文

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Akam, E. A.; Chang, T. M.; Astachkine, A. V.; Tomat*, E. "Intracellular reduction/activation of a disulfide switch in thiosemicarbazone iron chelators" Metallomics 2014, 6, 1905-1912. Chang, T. M.; Sinharay, S.; Astachkine, A. V.; Tomat*, E. "Prodigiosin analogue designed for metal coordination: Stable zinc and copper pyrrolyldipyrrins" Inorg. Chem. 2014, 53, 7518-7526. Chang, T. M.; Tomat*, E. "Disulfide/thiol switches in thiosemicarbazone ligands for redox-directed iron chelation" Dalton Trans. 2013, 42, 7846-7849. Blakemore, L. J.; Tomat, E.; Lippard, S. J.; Trombley, P. Q. "Zinc Released from Olfactory Bulb Glomeruli by Patterned Electrical Stimulation of the Olfactory Nerve" Metallomics 2013, 5, 208-213. Pluth, M. D.; Tomat, E.; Lippard S. J. "Biochemistry of Mobile Zinc and Nitric Oxide Revealed by Fluorescent Sensors" Annu. Rev. Biochem. 2011, 80, 333-355. Tomat, E.; Lippard, S. J. "Ratiometric and Intensity-Based Zinc Sensors Built on Rhodol and Rhodamine Platforms" Inorg. Chem. 2010, 49, 9113-9115. You, Y.; Tomat, E.; Hwang, K.; Atanasijevic, T.; Nam, W.; Jasanoff, A. P.; Lippard, S. J. "Manganese Displacement from Zinpyr-1 Allows Zinc Detection by Fluorescence Microscopy and Magnetic Resonance Imaging" Chem. Commun. 2010, 4139-4141. Tomat, E.; Lippard, S. J. "Imaging Mobile Zinc in Biology" Curr. Op. Chem. Biol. 2010, 14, 225-230. Tomat, E.; Nolan, E. M.; Jaworski, J.; Lippard, S. J. "Organelle-specific Zinc Detection Using Zinpyr-labeled Fusion Proteins in Live Cells" J. Am. Chem. Soc. 2008, 130, 15776-15777. Cuesta, L.; Tomat, E.; Lynch, V. M.; Sessler, J. L. "Binuclear Organometallic Ruthenium Complexes of a Schiff-Base Expanded Porphyrin" Chem. Commun. 2008, 3744-3746. Tomat, E.; Cuesta, L.; Lynch, V. M.; Sessler, J. L. "Binuclear Fluoro-Bridged Zinc and Cadmium Complexes of a Schiff Base Expanded Porphyrin: Fluoride Abstraction from the Tetrafluoroborate Anion" Inorg. Chem. 2007, 46, 6224-6226. Sessler, J. L.; Tomat, E. "Transition Metal Complexes of Expanded Porphyrins" Acc. Chem. Res. 2007, 40, 371-379. Sessler, J. L.; Melfi, P. J.; Tomat E.; Lynch, V. M. "Copper(II) and Oxovanadium(V) Complexes of Hexaphyrin(1.0.1.0.0.0)" Dalton Trans. 2007, 629-632. Sessler, J. L.; Tomat, E.; Lynch, V. M. "Coordination of Oxovanadium(V) in an Expanded Porphyrin Macrocycle" Chem. Commun. 2006, 4486-4488 (highlighted as hot article, cover feature). Sessler, J. L.; Tomat, E.; Lynch, V. M. "Positive Homotropic Allosteric Binding of Silver(I) Cations in an Schiff Base Oligopyrrolic Macrocycle" J. Am. Chem. Soc. 2006, 128, 4184-4185. Veauthier, J. M.; Tomat, E.; Lynch, V. M.; Sessler, J. L.; Mirsaidov, U.; Markert, J. T. "Calix[4]pyrrole Schiff-base Macrocycles. Novel Binucleating Ligands for Cu(I) and Cu(II)" Inorg. Chem. 2005, 44, 6736-6743. Sessler, J. L.; Tomat, E.; Mody, T. D.; Lynch, V. L.; Veauthier, J. M.; Mirsaidov, U.; Markert, J. T. "A Schiff Base Expanded Porphyrin Macrocycle that Acts as a Versatile Binucleating Ligand for Late First-Row Transition Metals" Inorg. Chem. 2005, 44, 2125-2127.