Gao, Xue (Sherry) - Rice University - Chemical and Biomolecular Engineering

个人简介

Dr. Xue (Sherry) Gao joined Rice University in 2017, as the Ted N. Law Assistant Professor in the Department of Chemical and Biomolecular Engineering. Dr. Gao obtained her doctoral degree in Chemical and Biomolecular Engineering from University of California, Los Angeles in 2013, under the guidance of Professor Yi Tang. She was a postdoctoral associate in the Department of Chemistry and Chemical Biology at Harvard University, working in the laboratory of Professor David R. Liu. She received both of her Bachelor’s and Master’s degrees in Chemical Engineering at Tianjin University in China with the guidance of Prof. Yingjin Yuan. Education 2013 Ph.D., Chemical and Biomolecular Engineering, UC Los Angeles 2007 M.S., Pharmaceutical Engineering, Tianjin University 2005, B.S., Pharmaceutical Engineering, Tianjin University

研究领域

Dr. Gao’s research program lies at the interface of chemical biology and biomolecular engineering with primary focus on small- and macro-molecule discovery and their applications to human health, agriculture, and energy. Natural products from microorganisms of diverse origins have played an extremely important role historically in drug discovery. Recent advances in human microbiome research have expanded our understanding of interactions between microbes and hosts related to human health. This unique microbial community also provides a golden opportunity for the discovery of new therapeutics. One of her main research is microbiome-based natural product discovery and engineering, and moreover, to develop enzymes involved in the natural product biosynthesis as powerful biocatalysts for difficult chemical reactions in the pharmaceutical and biotechnology industries. The recently discovered microbial ribonucleoprotein, CRISPR/Cas9, in complex with a single guide RNA, has been extensively applied to mediate genome—editing both in vitro and in vivo. Human genetic diseases were previously recognized to be untreatable until recent advances in genome-editing research, which have been revolutionizing medicine for treating human genetic diseases. Another main research interest of her group is to discover and develop advanced genome-editing agents and delivery systems and apply these genome-editing tools as next-generation therapeutics to clinical treatment of human genetic diseases.

近期论文

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Weng, Z. Y.†, Zheng, Y.†, Li, H.J.†; Wu, G.F., Song, Y., Sun, H., Lin, M.S., Gao, X.* Zhang, Y.* CRISPR-Cas12a-Mediated Graphene Field-Effect Transistors for Ultrasensitive and Amplification-Free Detection of DNA. In revision, 2023. Weng, Z.Y.†, Zheng, Y.†, Yang, J., Noor, M., Lin, M.S., Wei, Q.S., Gao, X.* Zhang, Y.* CRISPR-Cas Biochemistry and CRISPR-Based Molecular Diagnostics. In revision, 2023. Liu, Z.W.†, Rivera, S.†, Newmister, S. A.†, Sanders, J. N.†, Nie, Q. Y., Liu, S., Zhao, F. L., Ferrara, J., Shi, H. W., Patil, S.#, Xu, W. J., Miller, M. D., Phillips, Jr., G. N., Houk, K. N.*, Sherman, D. H.*, Gao, X.* An NmrA-like enzyme-catalysed redox-mediated Diels-Alder cycloaddition with anti-selectivity. Nature Chemistry. 2023, doi.org/10.1038/s41557-022-01117-6. Ma, D.C.†, Yuan, Q.C.†, Peng, F.†, Paredes, V., Zeng, H.Z., Osikpa, E.C., Yang, Q.C., Peddi, A.#, Patel, A.#, Liu, M.S.#, Sun, Z.*, Gao, X.* Engineered PROTAC-CID systems for mammalian inducible gene regulation. Journal of the American Chemical Society. 2023, Zhao, F.L.†, Sun, C.X.†, Liu, Z.W., Cabrera, A., Escobar, M., Huang, S.Y., Yuan, Q.C., Nie, Q.Y., Lee Luo, K., Lin, A.#, Vanegas, J. A.#, Zhu, T., Isaac B. Hilton, Gao, X.* Multiplex base-editing enables combinatorial epigenetic regulation for genome mining of fungal natural products. Journal of the American Chemical Society. 2023, 145, 1, 413–421, doi.org/10.1021/jacs.2c10211. Yang, J.†, Song, Y.†, Xiang, D, Vanegas, J.A., You, Z., Zhang, Y.X., Weng, Z., Avery, L., Dieckhaus, K.D., Peddi, A., Gao, Y.*, Zhang, Y.*, and Gao, X.* Engineered LwaCas13a with enhanced collateral activity for nucleic acid detection. Nature Chemical Biology. 2022, doi.org/10.1038/s41589-022-01135-y. Nie, Q.Y., Guo, S.Q., and Gao, X.* Unraveling the biosynthesis of penicillenols by genome mining polyketide synthase and nonribosomal peptide synthetase gene clusters in Penicillium citrinumPenicillium citrinum. AIChE J. 2022, e17885. Ditzel, A., Zhao, F.L., Gao, X., Phillips, G.N. Utilizing a Cell-free Protein Synthesis Platform for Natural Product Synthesis. preprint 2022, doi: 10.1101/2022.07.22.501086. Alvarez, V.L., Tao, Y., Li, Y.R., Du, W., Whittaker, M., Zuris, J., Thompson, D., Zhu, W. L., Rameshbabu, A.P., Shu, Y.L., Gao, X., Ju, J., Kong, W.J., Liu, X.Z., Wu, H., Kleinstiver, B., Liu, D.R., Chen, Z.Y. “Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo.” preprint 2022, doi:10.21203/rs.3.rs-1836399/v1. Gao, X., Ma, D.C., Provisional patent filed, 2022. Li, H.J.†, Yang, J.†, Wu, G.F. †, Weng, Z.Y. †, Song, Y., Venegas, J.A., Avery, L., Gao, Z., Sun, H., Dieckhaus, K.D., Gao, X.* and Zhang. Y.* Amplification-free and ultrasensitive nucleic acid detection via the synergy of CRISPR Cas13a and graphene field-effect transistors. Angewandte Chemie International Edition. 2022, e202203826. Yuan, Q.C. and Gao, X*. Multiplex base- and prime-editing with compact tRNA-CRISPR arrays. Nature Communications. 2022, 13 (1), 1-13. Fu, R.J., He, W., Dou, J.Z., Villarreal, O.D., Bedford, E., Wang, H., Hou, C., Zhang, L., Wang, Y.L., Ma, D.C., Chen, Y.W., Gao, X., Depken, M., Xu, H.* Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity. Nature Communications. 2022, 13, 474. Gao, X., Yang, J., and Gao, Y., “Engineered Cas13 for ultrasensitive nucleic acid detection”, U.S. Provisional Application No. 63/285,304, 2021 Wang, Q.†, Yang, J.†, Zhong, Z.C., Vanegas, J.A., Gao, X.*, Kolomeisky, A.B.* A general theoretical framework to design base editors with reduced bystander effects. Nature Communications. 2021, 12, 6529. Liu, Z.W.†, Zhao, F.L.†, Zhao, B.Y.†, Yang, J., Ferrara, J., Sankaran, B., Prasad, B.V.V., Phillips, G.N. Jr., Gao, Y., Hu, L., Zhu, T.*, Gao, X.*. “Structural and molecular basis of the stereoselective formation of the spirooxindole rings in the biosynthesis of citrinadins.” Nature Communications. 2021, 12, 4158. Gao, X., Lee, S., and Ding, N., Single base editing tools with precise accuracy. US Patent App. 17/104,562, 2021 Lee, S.S.†, Ding, N.†, Sun, Y.D, Yuan, T.L., Li, J., Yuan, Q.C., Liu, L.Z., Yang, J., Wang, Q., Kolomeisky, A.B., Hilton, I.B, Zuo, E.W.*, Gao, X.* Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects. Science Advances. 2020, 15, 6(29), eaba1773. Zhao, F.L., Liu, Z.W., Yang, S.Y., Ding, N., Gao, X.* Quinolactacin Biosynthesis Involves NRPSs Catalyzed Dieckmann Condensation to Form the Quinolone‐γ‐lactam Hybrid. Angewandte Chemie International Edition. 2020, 19, 59(43), 1910819114.