李毓龙 - 北京大学 - Idg/麦戈文大脑研究所

个人简介

Academic History 2000-2006 Ph.D., Dept. of Neurobiology, Duke University. 1996-2000 BS, School of life sciences, Peking University. Positions 2020.8- Full Professor (tenured), School of Life Sciences, Peking University. 2012.11- Principal Investigator, PKU-THU Center for Life Sciences. IDG/McGovern Institute For Brain Research. 2019.8-2020.7 Associate Professor (tenured), School of Life Sciences, Peking University. 2012.11-2019.7 Assistant Professor, School of Life Sciences, Peking University. 2006-2012.7 Postdoctoral Fellow, Dept. of Molecular and Cellular Physiology, Stanford University. Professional Experience 2019- Reviewing Editor of Journal of Neurochemistry

研究领域

人的大脑由数十亿的神经元组成，后者又通过数万亿的突触组成复杂的神经网络。不同种类的神经元经过或远或近的投射，通过突触与其他神经元进行信息交流，实现感知觉、决策和运动等高级神经功能。研究大脑的最大挑战在于脑的高度复杂性。我们实验室集中在神经元通讯的基本结构突触上，从两个层面上开展研究：一是开发前沿的工具，即开发新型成像探针，用于在时间和空间尺度上解析神经系统的复杂功能；二是借助先进的工具探究突触传递的调节机制，特别是在生理及病理条件下对神经递质释放的调节。具体而言，对于工具开发，我们集中于： 1、结合光遗传学和荧光成像，无损伤性的研究神经元之间的电突触连接。电突触的异常可导致耳聋、癫痫、脑部肿瘤和心脏功能异常等疾病。 2、开发可遗传编码的检测神经递质/调质的荧光探针。神经递质/调质是神经元化学突触传递的关键介导分子，与感知、学习和记忆以及情绪密切相关。利用上述荧光探针，我们的功能性和生理性的研究集中于： 1、结合双光子成像和可遗传编码的荧光探针，使用果蝇和小鼠作为模式生物，研究嗅觉传导或睡眠过程中脑的工作机制。 2、寻找上述新型化学递质/调质小分子的对应受体，即寻找“孤儿”受体的配体。 3、结合生物信息学、分析化学、生物化学、生理学和成像学方法，系统地探索和鉴定潜在的新型小分子神经递质。

近期论文

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