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Solution Structure of SpoIVB Reveals Mechanism of PDZ Domain-Regulated Protease Activity. Xie X, Guo N, Xue G, Xie D, Yuan C, Harrison J, Li J, Jiang L, Huang M. Front Microbiol. 2019 Jun 12;10:1232. doi: 10.3389/fmicb.2019.01232. eCollection 2019.
Expression and purification of recombinant serine protease domain of human coagulation factor XII in Pichia pastoris. Peng B, Xue G, Xu D, Feng Z, Chen J, Huang M, Lu H, Gong L. Biosci Biotechnol Biochem. 2019 May 22:1-7. doi: 10.1080/09168451.2019.1621151. [Epub ahead of print]
Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit. Liu M, Lin L, Høyer-Hansen G, Ploug M, Li H, Jiang L, Yuan C, Li J, Huang M. FEBS Lett. 2019 Jun;593(11):1236-1247. doi: 10.1002/1873-3468.13397. Epub 2019 May 15.
Nanoparticle Binding to Urokinase Receptor on Cancer Cell Surface Triggers Nanoparticle Disintegration and Cargo Release. Li S, Yuan C, Chen J, Chen D, Chen Z, Chen W, Yan S, Hu P, Xue J, Li R, Zheng K, Huang M. Theranostics. 2019 Jan 25;9(3):884-899. doi: 10.7150/thno.29445. eCollection 2019.
Structural determination of group A Streptococcal surface dehydrogenase and characterization of its interaction with urokinase-type plasminogen activator receptor. Li R, Liang C, Jiang L, Yuan C, Huang M. Biochem Biophys Res Commun. 2019 Mar 19;510(4):539-544. doi: 10.1016/j.bbrc.2019.01.102. Epub 2019 Feb 6.
A novel ELISA for the detection of active form of plasminogen activator inhibitor-1 based on a highly specific trapping agent. Shang L, Xue G, Gong L, Zhang Y, Peng S, Yuan C, Huang M. Anal Chim Acta. 2019 Apr 11;1053:98-104. doi: 10.1016/j.aca.2018.12.005. Epub 2018 Dec 12.
Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides. Wang D, Yang Y, Jiang L, Wang Y, Li J, Andreasen PA, Chen Z, Huang M, Xu P. J Med Chem. 2019 Feb 28;62(4):2172-2183. doi: 10.1021/acs.jmedchem.8b01908. Epub 2019 Feb 15.
tPA Point Mutation at Autolysis Loop Enhances Resistance to PAI-1 Inhibition and Catalytic Activity. Peng S, Xue G, Chen S, Chen Z, Yuan C, Li J, Huang M. Thromb Haemost. 2019 Jan;119(1):77-86. doi: 10.1055/s-0038-1676518. Epub 2018 Dec 31.
Novel pH-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment. Wang Y, Zheng K, Xuan G, Huang M, Xue J. Int J Nanomedicine. 2018 Nov 19;13:7681-7695. doi: 10.2147/IJN.S181199. eCollection 2018.
Small Peptides as Modulators of Serine Proteases. Xu P, Huang M. Curr Med Chem. 2018 Oct 16. doi: 10.2174/0929867325666181016163630. [Epub ahead of print]
Enhanced anti-microbial effect through cationization of a mono-triazatricyclodecane substituted asymmetric phthalocyanine. Lin H, Chen J, Zhang Y, Ulla A, Liu J, Lin F, Jiang L, Huang M. J Inorg Biochem. 2018 Dec;189:192-198. doi: 10.1016/j.jinorgbio.2018.10.001. Epub 2018 Oct 6.
6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer. Buckley BJ, Aboelela A, Minaei E, Jiang LX, Xu Z, Ali U, Fildes K, Cheung CY, Cook SM, Johnson DC, Bachovchin DA, Cook GM, Apte M, Huang M, Ranson M, Kelso MJ. J Med Chem. 2018 Sep 27;61(18):8299-8320. doi: 10.1021/acs.jmedchem.8b00838. Epub 2018 Sep 7.
Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217. Xu M, Chen Y, Xu P, Andreasen PA, Jiang L, Li J, Huang M. FEBS Lett. 2018 Aug;592(15):2658-2667. doi: 10.1002/1873-3468.13191. Epub 2018 Jul 30.
Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition. Jiang L, Oldenburg E, Kromann-Hansen T, Xu P, Jensen JK, Andreasen PA, Huang M. Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):2017-2023. doi: 10.1016/j.bbagen.2018.06.016. Epub 2018 Jun 27.
Near-infrared-triggered antibacterial and antifungal photodynamic therapy based on lanthanide-doped upconversion nanoparticles. Zhang Y, Huang P, Wang D, Chen J, Liu W, Hu P, Huang M, Chen X, Chen Z. Nanoscale. 2018 Aug 23;10(33):15485-15495. doi: 10.1039/c8nr01967c.
Insights into the binding mechanism of BODIPY-based photosensitizers to human serum albumin: A combined experimental and computational study. Chen Y, Liu J, Song M, Jiang L, Liu L, Liu Y, Fu G, Xue J, Liu JY, Huang M, Li J. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Oct 5;203:158-165. doi: 10.1016/j.saa.2018.05.103. Epub 2018 May 29.
The CD163 long-range scavenger receptor cysteine-rich repeat: expression, purification and X-ray crystallographic characterization. Li R, Ma H, Jiang L, Qiao S, Zhi Y, Huang M, Deng R, Zhang G. Acta Crystallogr F Struct Biol Commun. 2018 May 1;74(Pt 5):322-326. doi: 10.1107/S2053230X18005551. Epub 2018 Apr 25.
A novel purification procedure for recombinant human serum albumin expressed in Pichia pastoris. Li S, Li L, Chen Z, Xue G, Jiang L, Zheng K, Chen J, Li R, Yuan C, Huang M. Protein Expr Purif. 2018 Sep;149:37-42. doi: 10.1016/j.pep.2018.04.012. Epub 2018 Apr 18.
Smart Photosensitizer: Tumor-Triggered Oncotherapy by Self-Assembly Photodynamic Nanodots. Jia Y, Li J, Chen J, Hu P, Jiang L, Chen X, Huang M, Chen Z, Xu P. ACS Appl Mater Interfaces. 2018 May 9;10(18):15369-15380. doi: 10.1021/acsami.7b19058. Epub 2018 Apr 24.
Household light source for potent photo-dynamic antimicrobial effect and wound healing in an infective animal model.Ullah A, Zhang Y, Iqbal Z, Zhang Y, Wang D, Chen J, Hu P, Chen Z, Huang M. Biomed Opt Express. 2018 Feb 6;9(3):1006-1019. doi: 10.1364/BOE.9.001006. eCollection 2018 Mar 1. PMID: 29541500 Free PMC Article
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