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个人简介

学习经历 2003.08-2006.03 加拿大Saskatchewan大学 博士后 1997.07-2000.12 第三军医大学 人体解剖与组织胚胎学 博士研究生 1992.07-1995.08 第三军医大学 人体解剖与组织胚胎学 硕士研究生 1985.07-1990.08 第三军医大学 临床医学 本科生 工作经历 2017.08-至今 陆军军医大学基础医学院组织胚胎学教研室主任, 教授 2008.09-2017.07 第三军医大学基础部组织胚胎学教研室 主任, 教授 2007.09-2008.08 第三军医大学基础部组织胚胎学教研室 教授 2007.05-2007.11 加拿大Saskatchewan 大学访问教授 2002.09-2007.08 第三军医大学基础部组织胚胎学教研室 副教授 1996.09-2002.08 第三军医大学基础部组织胚胎学教研室 讲师 1990.07-1992.08 第三军医大学训练部组织胚胎学教研室 助教 教学课程有本科五年制、八年制的“组织学与胚胎学”,研究生“组织化学与细胞化学技术”和“发育生物学”。 2.专利: [1] 少突胶质细胞前体细胞的分离纯化方法,牛建钦, 肖岚ZL200910251053X, 证书号:817781 [2] 国家发明专利:李成仁、肖岚、汪云、李红丽《富马酸喹硫平在制备治疗胶质瘤药物中的应用》(专利号:ZL201510449370.8) 3.项目: [1] 国家自然科学基金创新团队(CNSF31921003.2021/01-2025/12)主要成员 [2] 国家自然科学基金面上项目,31970921,OPC分泌Wnt信号调控星形胶质网络形成及其在精神行为中的作用和机制,2020/01-2023/12,58万,在研, 主持。 [3] 国家自然科学基金面上项目,31671117,精神分裂症相关DISC1选择性剪接导致少突胶质细胞分化障碍和精神行为异常,2017/01-2020/12,62万,在研, 主持。 [4] 重庆市科技创新领军人才支持计划,CSTCKJCXLJRC07,2015/10-2018/10。45万元,已结题,主持。 [5] 国家自然科学基金面上项目,81471297,喹硫平促进BAF155依赖的染色质重塑在中枢神经系统髓鞘再生中的作用和机制研究,2015/01-2018/12,70万,已结题,主持。 [6] 国家自然基金海外合作项目,31228011,促中枢神经髓鞘再生因子的筛选和作用研究:工程化髓鞘支架的运用,2013/01-2014/12,20万,已结题,参加。 [7] 国家自然基金面上项目,31171046,胶质细胞间连接通道调控少突胶质前体细胞增殖与分化的作用和机制研究,2012/01-2015/12,52万,已结题,主持。 [8] 国家自然基金面上项目,81071084,精神分裂症缺失基因1(DISC1)调控少突胶质细胞发育分化的作用和机制研究,2011/01-2013/12,34万,已结题,主持。 [9] 重庆市自然科学基金计划重点项目,CSTC2011BA5006,少突胶质细胞异常参与精神分裂症发病机理的实验研究,2011/04-2014/04,20万,已结题,主持。 [10] 科技部国际科技交流与合作专项,2010DBF30820,精神分裂症少突胶质细胞异常假说的系统研究,2010/01-2012/12,40万(子课题),已结题,主持。 [11] 国家自然基金面上项目,30870801,Olig1与SOX10的协同在喹硫平促进少突胶质细胞成熟分化中的作用机制,2009/01-2011/12,25万,已结题,主持。 [12] 国家自然基金面上项目,30672447,非典型性抗精神病药促进少突胶质细胞发育和髓鞘再生的实验研究,2007/01-2009/12,30万,已结题,主持。 4.获奖: [1] 重庆市学位与研究生教育学会研究生教育教学改革研究优秀成果奖:基于TBT教学模式构建研究生医学形态学综合课程的实践探, 2020 (排名1) [2] 2019国际基因工程机器大赛iEGM金奖,及基础进步奖提名(团队负责人) [3] 国务院政府特殊津贴Special government allowances of the State Council 2019/1/16 [4] 军队教学成果三等奖:发育生物学科研创新实践促进医学本科生素质教育的实践,2018,2018-JDJXCG-3-082-01(排名1) [5] 重庆市自然科学二等奖:少突胶质细胞的发育及其异常导致精神分裂症的实验研究,2016年(排名1) [6] 重庆市“科技创新领军人才支持计划”CSTCKJCXLJRC07 2015 [7] 军队育才金奖,2014 [8] 重庆市教学成果一等奖:发育生物学科研创新实践促进医学本科生素质教育的实践,2013年(排名1) [9] 军队育才银奖,2009 [10] 重庆市自然科学二等奖2002年(排名9)

研究领域

研究方向为发育神经生物学,主要集中在中枢神经系统髓鞘发育与再生,以及精神疾病的髓鞘生物学机制。

近期论文

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文章 (* 通讯作者) [1] Li T, Niu J, Yu G, Ezan P, Yi C, Wang X, Koulakoff A, GaoX, Chen X,. Sáez JC Giaume C,Xiao L*. Connexin 43 Deletion in Astrocytes Promotes CNS Remyelination by Modulating Local Inflammation.Glia, 2020 Jun; 68(6):1201-1212. doi: 10.1002/glia.23770.(IF5.984) [2] Wang F#, Ren SY#, Chen JF, Liu K, Li RX, Li ZF, Hu B, Niu JQ,Xiao L, Chan JR*, Mei F*. Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory.Nat Neurosci. 2020 Feb 10. doi: 10.1038/s41593-020-0588-8. [Epub ahead of print] (IF 21.126) [3] Chen X, Liu H., Gan J, Wang X, Yu G, Li T, Liang X,Xiao L*. Quetiapine modulates histone methylation status in oligodendroglia and rescues adolescent behavioral alterations of socially isolated mice.Frontier in Psychiatry. 2020 Jan 31;10:984. (IF3.13) [4] Chen X, Wang F, Gan J, Zhang Z, Liang X, Li T, Huang N, Zhao X, Mei F,Xiao L*. Myelin Deficits Caused by Olig2 Deficiency Lead to Cognitive Dysfunction and Increase Vulnerability to Social Withdrawal in Adult Mice.Neurosci Bull. 2019 Nov 22. doi: 10.1007/s12264-019-00449-7. [Epub ahead of print] (IF4.246) [5] Niu J, Tsai HH, Hoi KK, Huang N, Yu G, Kim K, Baranzini SE,Xiao L, Chan JR, Fancy SPJ*. Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation.Nat Neurosci. 2019 Apr 15. doi: 10.1038/s41593-019-0369-4(IF 21.126) [6] Shen HY, Huang N, Reemmer J,Xiao L*. Adenosine Actions on Oligodendroglia and Myelination in Autism Spectrum Disorder.Front Cell Neurosci. 2018 Dec 7;12:482. doi: 10.3389 (IF4.289) [7] Chen X, Duan H,Xiao L, Gan J. Genetic and Epigenetic Alterations Underlie Oligodendroglia Susceptibility and White Matter Etiology in Psychiatric Disorders.Front Genet. 2018 Nov 22;9:565. doi: 10.3389/fgene.2018.00565. eCollection 2018. Review. [8] Wang F, Yang YJ, Yang N, Chen XJ, Huang NX, Zhang J, Wu Y, Liu Z, Gao X, Li T, Pan GQ, Liu SB, Li HL, Fancy SPJ,Xiao L*, Chan JR*, Mei F*. Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia. Neuron. 2018 Aug 22;99(4):689-701. (IF14.318) [9] Li T, Wang J, Wang H, Yang Y, Wang S, Huang N, Wang F, Gao X, Niu J, Li Z, Mei F*,Xiao L*. The deletion of dicer in mature myelinating glial cells causes progressive axonal degeneration but not overt demyelination in adult mice.Glia. 2018 Sep;66(9):1960-1971. doi: 10.1002/glia.23450. (IF5.846) [10] Li T, Wang L, Ma T, Wang S, Niu J, Li H,Xiao L*. Dynamic Calcium Release From Endoplasmic Reticulum Mediated by Ryanodine Receptor 3 Is Crucial for Oligodendroglial Differentiation. Front Mol Neurosci. 2018 May 18;11:162. doi: 10.3389/fnmol.2018.00162. eCollection 2018. (IF 3.902) [11] Cree BAC, Niu J, Hoi KK, Zhao C, Caganap SD, Henry RG, Dao DQ, Zollinger DR, Mei F, Shen YA, Franklin RJM, Ullian EM,Xiao L, Chan JR, Fancy SPJ. Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury.Brain. 2018 Jan 1;141(1):85-98. doi: 10.1093/brain/awx312. [12] Chen X, Ku Li, Mei R, Liu G, Xu C, Wen Z, Zhao X, Wang F,Xiao L* and Feng Y*.. Novel schizophrenia risk factor pathways regulate FEZ1 to advance oligodendroglia development.Transl Psychiatry. 2017 Dec 18;7(12):1293. doi: 10.1038/s41398-017-0028-z. (IF 4.86) [13] Jin XR, Chen XS*,Xiao L*. MeCP2 Deficiency in Neuroglia: New Progress in the Pathogenesis of Rett Syndrome.Front Mol Neurosci. 2017 Oct 4;10:316. doi: 10.3389/fnmol.2017.00316. eCollection 2017 (IF5.076) [14] Wang Y, Huang N, Li H, Liu S, Chen X, Yu S, Wu N, Bian XW, Shen HY, Li C*,Xiao L*. Promoting oligodendroglial-oriented differentiation of glioma stem cell: a repurposing of quetiapine for the treatment of malignant glioma.Oncotarget. 2017 Jun 6;8(23):37511-37524. (IF 5.168) [15] Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, A Sagan S, Xiao L, Teuscher C, von Büdingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan JR. Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery. Elife. 2016 Sep 27;5. pii: e18246. doi: 10.7554/eLife.18246 [16] Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS,Xiao L, Green AJ, Rowitch D, Whistler J, Chan JR. Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination.J Neurosci. 2016 Jul 27;36(30):7925-35. doi: 10.1523/JNEUROSCI.1493-16.2016. [17] Huang N, Chen D, Wu X, Chen X, Zhang X, Niu J*, Shen HY, Xiao L*. Aspirin Promotes Oligodendroglial Differentiation Through Inhibition of Wnt Signaling Pathway. Mol Neurobiol. 2016 Jul; 53(5):3258-66 (IF 6.19) [18] Niu J, Li T, Yi C2, Huang N, Koulakoff A, Weng C, Li C1, Zhao CJ, Giaume C*,Xiao L*. Connexin-based channels contribute to metabolic pathways in the oligodendroglial lineage. J Cell Sci. 2016 May 1;129 (9):1902-14 (IF 4.706) [19] Zhang XS, Huang J, Zhan CQ, Chen J, Li T, Kaye AD, Wu SX*,Xiao L*.Different Influences of Lipofection and Electrotransfection on In Vitro Gene Delivery to Primary Cultured Cortex Neurons.Pain Physician. 2016 Mar;19 (3):189-196. (IF 3.407) [20] Chen X, Zhang W, Li T, Guo Y, Tian Y, Wang F, Liu S, Shen HY, Feng Y*,Xiao L*. Impairment of oligodendroglia maturation leads to aberrantly increased cortical glutamate and anxiety-like behaviors in juvenile mice. Front Cell Neurosci. 2015,Dec 15;9:467 (IF 4.609) [21] Huang N, Feng Y,Xiao L*. Oligodendroglial Development: New Roles for Chromatin Accessibility.Neuroscientist, 2015 Dec; 21(6):579-88 (IF 7.391) [22] Wang H, Liu S, Tian Y, Wu X, He Y, Li C, Namaka M, Kong J, Li H*,Xiao L*. Quetiapine inhibits microglial activation by neutralizing abnormal STIM1 mediated intercellular calcium homeostasis and promotes myelin repair in a cuprizone -induced mouse model of de-myelination.Front Cell Neurosci, 2015 Dec 21;9:492. (IF 4.609) [23] Chen XS, Huang N, Michael N,Xiao L*. Advancements in the Underlying Pathogenesis of Schizophrenia: Implications of DNA Methylation in Glial Cells. Front Cell Neurosci.2015 Dec 2;9:451 doi: 10.3389/fncel.2015.00451. eCollection 2015. Review. (IF 4.609) [24] Teng Ma, Xiyan Wu, Qiyan Cai, Yun Wang,Lan Xiao, Yanping Tian,* and Hongli Li*. Lead Poisoning Disturbs Oligodendrocytes Differentiation Involved in Decreased Expression of NCX3 Inducing Intracellular Calcium Overload.Int. J. Mol. Sci. 2015, 16,19096-19110. [25] Wang H, Shen W, Hu X, Zhang Y, Zhuo Y, Li T, Mei F, Li X,Xiao L*, Chu T*. Quetiapine inhibits osteoclastogenesis and prevents human breast cancer-induced bone loss through suppression of the RANKL-mediated MAPK and NF-κB signaling pathways. Breast Cancer Res Treat. 2015 Feb;149(3):705-14 (IF 3.94) [26] Li T, Giaume C.Xiao L*. Connexins-mediated Glia Networking Impacts Myelination and Remyelination in the Central Nervous System.Mol Neurobiol. 2014 49(3):1460-71. (IF 5.286) [27] Mei F, Fancy S, ShenYA, Niu J, Zhao C, Bryan Presley, Miao E, Lee S, Mayoral S, Stephanie A. Redmond1, Ainhoa Etxeberria,Xiao L, Robin J. M. Franklin, Ari Green, Stephen L. Hauser, Chan JR. Fabricated micropillar arrays as a novel high-throughput screening.Nat Med. 2014 20 (8) 954-960 (IF 28.054) [28] Xiang A, Yunlai Liu, Maolin Qin, Chengren Li, Xingshu Chen, Lan Xiao, Jianjun Liu*, Expression of Dbn1 during mouse brain development and neural stem cell differentiation.Biochem Biophys Res Commun. 2014, 449(1):81-7. [29] Mei F, Wang H, Liu S, Wang L,Niu J,He Y,Etxeberria A, JChan JR* and Xiao L*,Stage-specific deletion of Olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes,J Neurosci .2013, 33(19):8454–8462(IF6.908) [30] Li C, Guan T, Chen X, Li W, Cai Q, Niu J,Xiao L*, Kong J*. BNIP3 mediates pre-myelinating oligodendrocyte cell death in hypoxia and ischemia.J Neurochem.2013 Nov;127(3):426-33 (IF4.25) [31] Wang H, Li C, Mei F, Liu Z, Shen HY, Xiao L*. Cuprizone-induced demyelination in mice: age-related vulnerability and exploratory behavior deficit. Neurosci Bull,2013, 29:251-259.(IF 1.832) [32] Yuan Ren, Hanzhi Wang and Xiao L*. Improving myelin/oligodendrocyterelated dysfunction: a new mechanism of antipsychotics in the treatment of schizophrenia?Int J Neuropsychopharmacol. 2013 Apr;16(3):691-700.(IF 5.641) [33] Tian Y, Chen W, Yang Y, Xu X, Zhang J, Wang J,Xiao L*,Chen Z*. Identification of B cell epitopes of dengue virus 2 NS3 protein by monoclonal antibody. Appl Microbiol Biotechnol. 2013 Feb; 97(4):1553-60.(IF3.762) [34] Niu J, Mei F, Wang L, Liu S, Tian Y, Mo W, Li HL, Lu Q. Richard and Xiao L*. Phosphorylated Olig1 Localizes to the Cytosol of Oligodendrocytes and Promotes Membrane Expansion and Maturation.Glia.2012 Sep; 60(9):1427-36.(IF 5.066) [35] Niu J, Wang L, Liu S, Li C, Kong J,and Xiao L*. An Efficient and Economical Culture Approach for Increasing the Yield of Purified Oligodendrocyte Progenitor Cells.J Neurosci Methods. 2012 Jun 9;209(1):241-249(IF 2.484) [36] Mei F, Guo S He Y, Wang L, Niu J, Wang H, Kong J, Li XM,Xiao L*. Quetiapine, an atypical antipsychotic, is protective against autoimmune-mediated demyelination by inhibiting effector T cell proliferation. PloSOne.2012 2012;7(8):e42746 (IF4.244) [37] Zhang Y, Zhang H, Wang L, Jiang W, Xu H, Xiao L, Bi X, Wang J, Zhu S, Zhang R, He J, Tan Q, Zhang D, Kong J, Li XM. Quetiapine enhances oligodendrocyte regeneration and myelin repair aftercuprizone-induced demyelinationSchizophrenia Res2012 138:8-17. (IF4.45) [38] He X, Yang WC, Wen XY, Tang D,Xiao L, Han J, Yu B, Zhang W, Mei F. Late embryonic and postnatal development of interstitial cells of cajal in mouse esophagus: distribution, proliferation and kit dependence.Cells Tissues Organs. 2012;196(2):175-88. Epub 2012 Jan 20.(IF2.433) [39] Wang Y, Zhang Y, He J, Zhang H,Xiao L, Nazarali A, Zhang Z, Zhang D, Tan Q, Kong J, Li XM. Hyperforin promotes mitochondrial function and development of oligodendrocytes. J Neurochem,2011 Nov, 119(3): 555-68.(IF4.25) [40] Wang HZ, Xu HY, Niu J, Mei F, Li X-M, Kong J, Cai W andXiao L*.Haloperidol activates quiescent oligodendroglia precursor cells in the white matter of adult brain, Schizophrenia Res, 2010 119:164-174(IF4.45) [41] Niu J, Mei F, Li N, Wang HZ andXiao L*. Haloperidol promotes proliferation but inhibits differentiation in rat oligodendrocyte progenitor cell cultures,Biochem Cell Biol, 2010, 88:611-620(IF 2.915) [42] Yunlai Liu, Minghui Huang, Yanqi Zhang, Hongli Li,Lan Xiao, Jianjun Liu, Bibo Yuan, Maolin Qin, Chengren Li,Micheal Yang,Wenqin Cai.Screening Genes Related to Development and Injury of the Mouse Optic Nerve by cDNA Microarrays.Cellular and Molecular Neurobiology. 2010; 30:869–876 (IF2.506) [43] Xu, H., Yang, H-J., Wang, H., Zhang, Y.,Xiao, L., Clough, R.W., Browning, R., Li, X-M. Region-specific susceptibilities to cuprizone-induced lesions in the mouse forebrain: implications for the pathophysiology of schizophrenia. Brain Res 2009, 123:418-429. [44] Zhang, Y., Xu, H., Jiang, W.,Xiao, L., Yan, B., He, J., Wang, Y., Bi, X., Li, X., Kong, J., and Li, X.-M. Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse. Schizophrenia Res, 2008,106(2-3):182-91. [45] Xiao, L., Xu, H., Zhang, Y., Wei, Z., Dyck, L., Devon, R.M., He, J., Jiang, W., and Li, X.-M.. (2008) Quetiapine facilitates oligodendrocyte development and prevents mice from cortical demyelination and behavioral changes. Mol Psychiatry, 2008, Jul;13(7):697-708.(5年IF 13.985) [46] Jiang W, Zhang Y,Xiao L, Van Cleemput J, Ji SP, Bai G and Zhang X. J Clin Invest. 2005 Nov;115(11):3104-16l. Cannabinoid promotes embryonic and adult hippocampus neurogenesis and produces anxiolytic- and antidepression-like effects. J. Clin. Invest., 2005, 115:3104-16(IF15.43) [47] Wen Jiang,Xiao L, Jin-Cun Wang, and et al. Effects of nitric oxide on dentate gyrus cell proliferation after seizures induced by pentylenetrazol in the adult rat brain. Neurosci Lett.2004 Sep 9; 367(3): 344-8 [48] Wen Jiang, Ken Wolfe,Lan Xiao and et al. Ion tropic glutamate receptor antagonists inhibit the proliferation of granule cell precursors in the adult brain after seizures induced by pentylenetrazol.Brain Res. 2004 Sep 10; 1020 (1-2): 154-60. [49] Xiao Lan, Cai wenqin. Expression and Distribution of Aromatase mRNA in the Developing Mouse Brain. Biomedical Research, 2003, 14 (2): 138-146 [50] 庾光丹,牛建钦,肖岚*。胶质细胞中葡萄糖转运机制研究进展。中国组织化学与细胞化学杂志,2016, 25(1):80-83 [51] 王小蕊, 孙豪,蔡其燕,肖岚*。小胶质细胞极化在中枢神经系统髓鞘再生中的作用研究进展。生理科学进展, 2016,47(5):386-390 [52] 郑杰,黄南昕,肖岚*。多发性硬化症中的表观遗传学调控研究进展, 生理科学进展, 2016, 47(6):455-458 [53] 刘淑宝,田衍平,陈显军,吴锡艳,肖岚* DISC1基因过表达对星形胶质细胞质膜伸展的影响第三军医大学学报2013, 35(10):938-942 [54] 陈显军,田衍平,肖岚*. 磷酸化Oligl/1Olig2参与少突胶质细胞发育调控作用的研究进展. 生命科学,2013, 25(5):474-477 [55] 王凌云,肖岚*。少突胶质细胞的钙信号。中华神经医学杂志,2013, 1(12):93-5 [56] 刘梦龙,李杰,肖岚*。少突胶质细胞的骨架在髓鞘形成中作用的研究进展。生理科学进展,2012, 43(6):422-26 [57] 任远,王晗知,肖岚*。Wnt /β-catenin 信号通路在髓鞘发育和再生过程中的作用*生理科学进展,2013,43(1)71-74 [58] 燕增奎,秦茂林,刘运来,李成仁,刘建军,肖岚*。C5aR1促进神经干细胞增殖作用的实验研究。免疫学杂志,2012;28(11):946~949。 [59] 王洪凯,梅峰,刘志,韦美,肖岚*。不同年龄小鼠脱髓鞘动物模型中脑内星形胶质细胞激活情况的观察。第三军医大学学报,2012;34(8):696~700 [60] 王凌云,田衍平,牛建钦,肖岚*。Cx43基因干扰对大鼠星形胶质细胞谷氨酸基础释放的影响,第三军医大学学报,2012, 34(8):701-704 [61] 张翔,卢楠,颜怀城,谢馨,肖岚.精神分裂症断裂基因1 在精神分裂症发病机制中的研究进展. 中国药业. 2011, 20(3): 77-78 [62] 贺雪莲,于洋,周永杰,何立,陈祥,肖岚,鲁青,王凡. 少突胶质细胞相关MicroRNA 差异性调控大脑和小脑神经前体细胞的增殖, 第三军医大学学报,2011,33(16):1667-1671 [63] 刘淑丹, 张桂祯,王晗知,肖岚,李红丽. 幼鼠癫痫持续状态成年后脑内髓鞘变化的研究. 第三军医大学学报, 2010; 32(13):1375-1378.刘淑丹, 张桂祯等,幼鼠癫痫持续状态成年后脑内髓鞘变化的研究. 第三军医大学学报, 2010; 32(13):1375-1378. 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