张翱 - 上海交通大学

个人简介

1988.09-1992.07 西华师范大学学士 1992.09-1995.07 南开大学硕士 1995.07-1997.10 上海有机化学研究所研究实习员 1997.11-2000.12 上海有机化学研究所理学博士 2001.02-2002.03 美国乔治城大学医学中心博士后 2002.04-2004.03 美国哈佛大学医学院博士后 2004.04-2006.02 美国哈佛大学医学院讲师、助理主任 2006.02-2020.04 中科院上海药物研究所研究员、博导、课题组长 2020.05- 上海交通大学药学院教授、博导、课题组长

研究领域

张翱课题组长期致力于药物化学技术创新推动的新药发现研究，尤其是通过基于靶标变构位点药物设计技术、泛素介导的靶向蛋白降解技术、蛋白翻译后修饰动态调控技术、DNA编码集中库设计技术、基因转录模拟物设计、药物分子后期修饰等药物设计新技术，结合基于药物代谢及血脑屏障通透性等药物结构优化策略，在与化学生物学、结构生物学和药理学等合作基础上，建立了多学科联合攻关的创新药物研究团队，聚焦新靶标新分子实体原创新药发现的药物化学和化学生物学研究、难靶蛋白的药物设计、分子靶向个性化药物研究等领域，取得了显著成绩

近期论文

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Liu X., Ding C., Tan W.*, Zhang A.* Medulloblastoma: “molecular understanding, treatment evolution, and new developments.” Pharmacol Ther. 2020,107516. Ding C., Chen H., Liang B., Jiao M., Liang G.*, Zhang A.* “Biomimetic synthesis of the natural product salviadione and its hybrids: discovery of tissue-specific anti-inflammatory agents for acute lung injury.” Chem. Sci. 2019, 10, 4667-4672. Xue Y., Song P., Song Z., Wang A., Tong L., Geng M., Ding J., Liu Q., Sun L.*, Xie H.*, Zhang A.* “Discovery of 4,7-diamino-5-(4-phenoxyphenyl) -6-methylene-pyrimido[5,4-b]pyrrolizines as novel Bruton's tyrosine kinase (BTK) inhibitors.” J. Med. Chem. 2018, 61, 4608-4627. Wang D., Yang Z., Wang C.*, Zhang A.*, Uchiyama M.* “From aniline to aryl ether: a facile, efficient and versatile synthetic protocol employing mild conditions.” Angew Chem. Int. Ed. 2018, 57, 3641-3645. Ding C., Tian Q., Li J., Jiao M., Song S., Wang Y.*, Miao Z.*, Zhang A.* “Structural modification of natural product tanshinone I leading to discovery of novel nitrogen-enriched derivatives with enhanced anticancer profile and improved drug-like properties.” J. Med. Chem. 2018, 61, 760-776. Liu G., Yang J., Wang J., Liu X., Huang W., Geng, Y., Tan W.*, Zhang A.* “Discovery of novel macrocyclic hedgehog pathway inhibitors acting by suppressing the Gli-mediated transcription.” J. Med. Chem. 2017, 60, 8218-8245. Liu G., Xue D., Yang J., Wang J., Liu X., Huang W., Li J., Long Y.*, Tan W.*, Zhang A.* “Design, synthesis and pharmacological evaluation of 2-(2,5-dimethyl- 5,6,7,8-tetrahydroquinolin -8-yl)-N-aryl propanamides as novel smoothened (Smo) antagonists.” J. Med. Chem. 2016, 59, 11050-11068. Wang Y., Wang P., Wang Y., Yang G., Zhang A.*, Miao Z.* “An update on poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors: opportunities and challenges in cancer therapy.” J. Med. Chem. 2016, 59, 9575-9598. Fan Z., Ni J., Zhang A.* “Meta-selective CAr-H nitration of arenes through a Ru3(CO)12-catalyzed ortho-metalation strategy.” J. Am. Chem. Soc. 2016, 138, 8470-8475. Wang M., Shen A., Zhang C., Song Z., Ai J., Liu H., Sun L.*, Ding J., Geng M.*, Zhang A.* “Development of heat shock protein (Hsp90) inhibitors to combat resistance to tyrosine kinase inhibitors through Hsp90-kinase interactions.” J. Med. Chem. 2016, 59, 5563-5586. Fan Z., Shu S., Ni J., Yao Q., Zhang A.* “Ligand-promoted Pd(II)-catalyzed functionalization of unactivated C(sp3)−H bond: regio- and stereoselective synthesis of arylated rimantadine derivatives.” ACS Catalysis, 2016, 6, 769-774. Wei M., Wang X., Song Z., Jiao M., Ding J., Meng L.*, Zhang A.* “Targeting PI3Kδ: emerging therapy for chronic lymphocytic leukemia and beyond.” Med. Res. Rev. 2015, 35,720-752. Song Z., Yang Y., Liu Z., Peng X., Guo J., Yang X., Wu K., Ai J.*, Ding J., Geng M.*, Zhang A.* “Discovery of novel 2,4-diarylaminopyrimidine analogues (DAAPalogues) showing potent inhibitory activities against both wild-type and mutant ALK kinases.” J. Med. Chem. 2015, 58, 197-211. Ye N., Neumeyer J. L., Baldessarini R. J., Zhen X., Zhang A.* “Recent progress in the development of dopamine receptor subtype compounds: potential therapeutic agents for neurological and neuropsychiatric disorders.” Chem. Rev. 2013, 113, PR123-PR178. Ye N., Chen C., Chen T., Song Z., He J., Huan X., Song S., Liu Q., Chen Y., Ding J., Xu Y.*, Miao Z.*, Zhang A.* “Design, synthesis and biological evaluation of a series of benzo[de][1,7] naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors.” J. Med. Chem. 2013, 56, 2885-2903. Zhang H., Ye N., Zhou S., Guo L., Zheng L., Liu Z., Gao B., Zhen X.*, Zhang A.* “Identification of N-propylnoraporphin-11-yl 5-(1,2-Dithiolan-3-yl)pentanoate as a new anti-parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile.” J. Med. Chem. 2011, 54, 4324-4338. Wang Y., Ai J., Wang Y., Chen Y., Wang L., Liu G., Geng M.*, Zhang A.* “Synthesis and c-Met kinase inhibition of 3,5-di- and 3,5,7-tri- substituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)- 5-(3-nitrobenzylamino)- 7- (trifluoromethyl)quinoline as a novel anticancer agent.” J. Med. Chem. 2011, 54, 2127-2142.