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从事有机不对称合成及有重要生理活性化合物的合成研究,致力于以一些重要有机分子及药物分子合成为导向的手性化学和手性技术探索。² 1.有机不对称合成、手性药物² 2.新型手性配体/催化剂的设计、合成以及在不对称反应中的应用研究² 3.具生理活性的有机分子、天然产物分子和药物合成中间体的高效合成策略及方法学研究² 4.治疗Alzheimer, COPD及糖尿病等重要疾病的小分子化学药物的研究和发现

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Lin Su, Ting-Shun Zhu and Ming-Hua Xu*, “Indium-mediated Asymmetric Intramolecular Allenylation of N-tert-Butanesulfinyl Imines: Efficient and Practical Access to Chiral 3-Allenyl-4-Aminochromanes”, Org. Lett. 2014, 16, 4118-4121. Diao Chen, and Ming-Hua Xu*, “Lewis Acid Promoted Diastereoselective Addition of TMSCN and TMSCF3 to Isatin-Derived N-Sulfinyl Ketimines: Synthesis of Optically Active Tetra-substitued 3-Aminooxindoles”, J. Org. Chem. 2014, 79, 7746-7751. Hui Wang, Yi Li, and Ming-Hua Xu*, “Rh-Catalyzed Highly Enantioselective Arylation of Cyclic Diketimines: Efficient Synthesis of Chiral Tetrasubstituted 1,2,5-Thiadiazoline-1,1-dioxides”, Org. Lett. 2014, 16, 3962-3965. Yue-Na Yu, and Ming-Hua Xu*, “Chiral Phosphite–Olefin Ligands: Application in Rh-Catalyzed Asymmetric 1,4-Addition of β-Aryl-α,β-unsaturated Sulfonates”, Acta Chimica Sinica 2014, 72, 815-819. (Invited contribution, Special Issue on Asymmetric Catalysis) Yue-Na Yu, and Ming-Hua Xu*, “Design of New Chiral Phosphite–Olefin Ligands and Their Application in Asymmetric Catalysis”, Org. Chem. Front. 2014, 1, 738-741. (Cover Article) Yi Li, and Ming-Hua Xu*, “Glyoxylic Acid” 2014, Encyclopedia of Reagents for Organic Synthesis [Online], John Wiley & Sons Ltd., DOI: 10.1002/047084289X.rg009. Yi Li, and Ming-Hua Xu*, “Rhodium-Catalyzed Asymmetric Tandem Cyclization for Efficient and Rapid Access to Underexplored Heterocyclic Tertiary Allylic Alcohols Containing a Tetrasubstituted Olefin”, Org. Lett. 2014, 16, 2712-2715. (Highlighted by SYNFACTS, 2014, 10(7), 0680) Yi Li, and Ming-Hua Xu*, “Simple sulfur-olefins as new promising chiral ligands for asymmetric catalysis”, Chem. Commun. 2014, 50, 3771-3782. (Invited Feature Article; Cover Article) Yi Li, Dong-Xing Zhu, and Ming-Hua Xu*, “A New Versatile Approach to Enantioenriched 3-Hydroxyoxindoles, 1,3-Dihydroisobenzofuran and 3-Isochromanone Derivatives by Rhodium-Catalyzed Asymmetric Arylation/Cyclization Sequence”, Chem. Commun. 2013, 49, 11659-11661. (Highlighted by SYNFACTS, 2014, 10(3), 0285; selected as an article of ChemComm Editor’s Choice) Hui Wang, and Ming-Hua Xu*, “Rhodium-Catalyzed Highly Enantioselective Addition of Arylboronic Acids to Cyclic Aldimines: Practical Asymmetric Synthesis of Cyclic Sulfamidates”, Synthesis 2013, 2125-2133. (Invited contribution, Special Issue on Rhodium Catalysis; Abstracted by ChemInform, 2013, 44, 52-195) Ting-Shun Zhu, and Ming-Hua Xu*, “Chiral Sulfinamide-Olefin Ligands: Switchable Selectivity in Rhodium-Catalyzed Asymmetric 1,2-Addition of Arylboronic Acids to Aliphatic α-Ketoesters”, Chin. J. Chem. 2013, 31, 321-328. (Dedicated to Professor Guo-Qiang Lin on the occasion of his 70th birthday; Abstracted by ChemInform, 2013, 44, 44-091) Yue-Na Yu, and Ming-Hua Xu*, “Enantioselective Synthesis of Chiral 3-Aryl-1-indanones through Rhodium-Catalyzed Asymmetric Intramolecular 1,4-addition”, J. Org. Chem. 2013, 78, 2736-2741. (Highlighted by SYNFACTS, 2013, 9(7), 0756; Abstracted by Organic Chemistry Portal and ChemInform, 2013, 44, 30-105) Thomas Gossas, Helena Nordström, Ming-Hua Xu, Zhi-Hua Sun, Guo-Qiang Lin, Hans Wallberg and Helena Danielson*, “The high affinity of hydroxamate-based MMP-12 inhibitors is due to an inherently slow dissociation of the enzyme-inhibitor complex”, Med. Chem. Commun. 2013, 4, 432-442. Hui Wang, Tao Jiang, and Ming-Hua Xu*, “Simple Branched Sulfur-Olefins as Chiral Ligands for Rh-Catalyzed Asymmetric Arylation of Cyclic Ketimines: Highly Enantioselective Construction of Tetrasubstituted Carbon Stereocenters”, J. Am. Chem. Soc. 2013, 135, 971-974. (Highlighted by SYNFACTS, 2013, 9(4), 0416; Abstracted by ChemInform, 2013, 44, 26-123) Jiahui Wu, Yi Li, Kaixian Chen, Hualiang Jiang, Ming-Hua Xu*, Dongxiang Liu*, “Identification of Benzofuran-3-yl(phenyl)methanones as Novel SIRT1 Inhibitors: Binding Mode, Inhibitory Mechanism and Biological Action”, Eur. J. Med. Chem. 2013, 60, 441-450. Hong-Yu Yang, and Ming-Hua Xu*, “Design and Synthesis of Polymeric Chiral Bicyclo[3.3.0] Diene as Reusable Ligand for Rhodium-Catalyzed Asymmetric 1,4-Addition”, Chin. J. Chem. 2013, 31, 119-122. (Invited contribution, Special Issue in Memory of Professor Weishan Zhou) Diao Chen, and Ming-Hua Xu*, “Zn-Mediated Asymmetic Allylation of N-tert-Butanesulfinyl Ketimines: An Efficient and Practical Access to Chiral Quaternary 3-Aminooxindoles”, Chem. Commun. 2013, 49, 1327-1329. (Abstracted by ChemInform, 2013, 44, 23-107) Yi Li, and Ming-Hua Xu*, “Lewis Acid-Catalyzed Intramolecular Aza-Friedel-Crafts Reaction of N-tert-Butanesulfinyl Imines: Efficient Synthesis of Optically Active 9-Aminofluorene Derivatives”, Asian J. Org. Chem. 2013, 2, 50-53. (Cover Article; One of the most-accessed papers in April of 2013) Ting-Shun Zhu, Jian-Ping Chen, and Ming-Hua Xu*, “Rh-catalyzed Enantioselective 1,2-Addition to Unsymmetrical α-Diketones: Tandem One-Pot Synthesis of Optical Active 3-Tetrasubstituted Isochroman Derivatives”, Chem. Eur. J. 2013, 19, 865-869. (Highlighted by SYNFACTS, 2013, 9(4), 0360; Abstracted by ChemInform, 2013, 44, 23-129) Hui Wang, Ting-Shun Zhu, and Ming-Hua Xu*, “Rhodium-Catalyzed Enantioselective 1,2-Addition of Arylboronic Acids to Heteroaryl α-Ketoesters: An Efficient Route to Heteroaromatic α-Hydroxy Esters”, Org. Biomol. Chem. 2012, 10, 9158 - 9164. (Cover Article, highlighted on the OBC blog; Abstracted by ChemInform, 2013, 44, 19-115)

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