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个人简介

1983.07 - 1988.03 上海中医药大学附属龙华医院,中西医结合肿瘤科,医师 1993.04 - 1995.03 日本学术振兴会,博士生/博士后特别研究员 1996.05 - 2000.08 美国国立卫生研究院,国立癌症研究院,实验免疫学分院(NIH/NCI/EIB),细胞介导免疫学研究室,博士后访问学者 2000.08 - 至今 上海药物研究所,免疫药理课题组组长,二级研究员 2000.12 - 至今 上海中医药大学,兼职教授、病毒免疫研究室主任

研究领域

从事免疫药理学研究,致力于难治性自身免疫性疾病和病毒感染性疾病的新药研发,建立了国际水准的免疫抑制和抗病毒药物研发平台,确立了一批原创性候选新药(化学药物1.1类):雷藤舒(治疗类风湿性关节炎)和异噻氟定(治疗乙型病毒性肝炎)已经完成1期临床研究;马来酸蒿乙醚胺(治疗系统性红斑狼疮)已经申报临床研究;另有3个候选新药正在开展全面的临床前研究。

近期论文

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Xu YB, Yang L, Wang GF, Tong XK, Wang YJ, Yu Y, Jing JF, Feng CL, He PL, Lu W, Tang W, Zuo JP*. Benzimidazole Derivative, BM601, a Novel Inhibitor of Hepatitis B Virus and HBsAg Secretion. Antiviral Res. 2014 Apr 15;107C:6-15 Yang L, Shi LP, Chen HJ, Tong XK, Wang GF, Zhang YM, Wang WL, Feng CL, He PL, Zhu FH, Hao YH, Wang BJ, Yang DL, Tang W, Nan FJ, Zuo JP*. Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation. Acta Pharmacol Sin. 2014 Mar;35(3):410-8 He SJ, Lin ZM, Zhang XH, Wu YW, Bai BX, Yang XQ, He PL, Zhu FH, Tang W*, Zuo JP*. Therapeutic effect of a reversible S-adenosyl-L-homocysteine hydrolase inhibitor in lupus-prone NZB×NZW F1 mice via interfering Toll-like receptor engaged antigen-presenting cell responses. Acta Pharmacol Sin. 2014 Feb;35(2):219-29 Li X, Li TT, Zhang XH, Hou LF, Yang XQ, Zhu FH, Tang W*, Zuo JP*. Artemisinin Analogue SM934 Ameliorates Murine Experimental Autoimmune Encephalomyelitis through Enhancing the Expansion and Functions of Regulatory T Cell. PLoS One. 2013 Aug 29;8(8):e74108 Kong FY, Chen W, He SJ, Lin ZM, Li X, Zhang XH, Yang XQ, Zhu FH, Tong XK, Zhou Y, Tang W, Duan WH*, Zuo JP*. Mycophenolic Acid Derivative 118 Treated Acute Skin Grafting Diseases through Suppressing the IL-17 Production. Acta Pharmacol Sin. 2013 Jul;34(7):921-9 Wan CP, Gao LX, Hou LF, Yang XQ, He PL, Yang YF, Tang W, Yue JM*, Li J*, Zuo JP*. Astragaloside triggers T cell activation through regulating the activity of CD45 protein tyrosine phosphatase. Acta Pharmacol Sin. 2013 Apr;34(4):522-30 Shi JJ, Ji FH, He PL, Yang YX, Tang W, Zuo JP, Li YC. Synthesis and hepatitis C antiviral activity of 1-aminobenzyl-1H-indazole-3-carboxamide analogues. ChemMedChem. 2013 May;8(5):722-5 Lu Y, Chen B, Song JH, Zhen T, Wang BY, Li X, Liu P, Yang X, Zhang QL, Xi XD, Chen SD, Zuo JP, Chen Z, Chen SJ. Eriocalyxin B ameliorates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2258-63 Du YJ, Lin ZM, Zhao YH, Feng XP, Wang CQ, Wang G, Wang CD, Shi W, Zuo JP, Li F, Wang CZ. Stability of the recombinant anti?erbB2 scFv?Fc?interleukin?2 fusion protein and its inhibition of HER2?overexpressing tumor cells. Int J Oncol. 2013 Feb;42(2):507-16 Feng E, Shin WJ, Zhu X, Li J, Ye D, Wang J, Zheng M, Zuo JP, No KT, Liu X, Zhu W, Tang W, Seong BL, Jiang H, Liu H. Structure-Based Design and Synthesis of C-1- and C-4-Modified Analogs of Zanamivir as Neuraminidase Inhibitors. J Med Chem. 2013 Feb 14;56(3):671-84 Zhang B, Wang Y, Yang SP, Zhou Y, Wu WB, Tang W, Zuo JP, Li Y, Yue JM. Ivorenolide A, an unprecedented immunosuppressive macrolide from Khaya ivorensis: structural elucidation and bioinspired total synthesis. J Am Chem Soc. 2012 Dec 26;134(51):20605-8 Tang W, Zuo JP*. Immunosuppressant discovery from Tripterygium wilfordii Hook f: the novel triptolide analog (5R)-5-hydroxytriptolide (LLDT-8). Acta Pharmacol Sin. 2012 Sep;33(9):1112-8 Ye D, Shin WJ, Li N, Tang W, Feng E, Li J, He PL, Zuo JP, Kim H, Nam KY, Zhu W, Seong BL, Tai No K, Jiang H, Liu H. Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities. Eur J Med Chem. 2012 Aug;54:764-70 Hou LF, He SJ, Li X, Wan CP, Yang Y, Zhang XH, He PL, Zhou Y, Zhu FH, Yang YF, LiY, Tang W, Zuo JP*. SM934 Treated Lupus-prone NZB × NZW F1 Mice by Enhancing Macrophage Interleukin-10 Production and Suppressing Pathogenic T Cell Development. PLoS ONE. 2012(7)2:e32424. doi:10.1371/journal.pone. 0032424 Deng J, Li N, Liu H, Zuo Z, Liew OW, Xu W, Chen G, Tong X, Tang W, Zhu J, Zuo J, Jiang H, Yang CG*, Li J*, Zhu W*. Discovery of Novel Small Molecule Inhibitors of Dengue Viral NS2B-NS3 Protease Using Virtual Screening and Scaffold Hopping. J Med Chem. 2012 Jul 26;55(14):6278-93 Liu MM, Zhou L, He PL, Zhang YN, Zhou JY, Shen Q, Chen XW, Zuo JP*, Li W*, Ye DY*. Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy. Eur J Med Chem. 2012 Jun;52:33-43 Wu J, Zhou Y, Wang LY, Zuo JP, Zhao WM*. Terpenoids from root bark of Celastrus orbiculatus. Phytochemistry 2012 Mar;75:159-68 Chao B, Tong XK, Tang W, Li DW, He PL, Jean-Michel Garcia, Zeng LM, Gao AH, Yang L, Li J, Nan FJ, Michael Jacobs, Ralf Altmeyer, Zuo JP*, Hu YH*. Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors. J Med Chem. 2012 Apr 12;55(7):3135-43 Zhang M, Yang XY, Tang W, Tom W.L.Groeneveld, He PL, Zhu FH, Li J, Lu W, Anna M. Blom, Zuo JP*, Nan FJ*. Discovery and Structural Modification of 1-Phenyl-3-(1-phenylethyl)urea Derivatives as Inhibitors of Complement. ACS Medicinal Chemistry Letters. 2012, 3, 317-321 Feng XJ, Yang XY, Luo Y, Li X, Tang W, Zuo JP*, Lu W*. Synthesis and immunomodulating activity of new analogues of fingolimod. Arch Pharm (Weinheim). 2012 Feb;345(2):93-100

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