李川 - 中国科学院上海药物研究所 -

研究领域

1.探索和建立中药多成分体系和多药体系药代动力学研究方法，发展关键技术，构建满足中药药代动力学研究需求的独特技术体系。 2.围绕中药有效性和安全性，研究中药活性成分药代属性、体内暴露特征与调控机制，鉴定反映给药后机体对中药物质暴露及影响因素的“药代标识物”，研究方剂配伍的药代作用机理与模式，为优化中药治疗创造条件。 3.开展中药大品种的药代动力学研究，支持中药制药企业的品种科技提升和新药研发。

近期论文

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Cheng C, Liu X-W, Du F-F, Li M-J, Xu F, Wang F-Q, Liu Y, Li C, Sun Y. Sensitive assay for measurement of volatile borneol, isoborneol, and the metabolite camphor in rat pharmacokinetic study of Borneolum (Bingpian) and Borneolum syntheticum (synthetic Bingpian). Acta Pharmacol Sin 2013; 34: 1337-1348. Chen F, Li L, Xu F, Sun Y, Du F-F, Ma X-T, Zhong C-C, Wang F-Q, Zhang N-T, Li C. Systemic and cerebral exposure to and pharmacokinetics of flavonols and terpene lactones after dosing standardized Ginkgo biloba leaf extracts to rats via different administration routes. Br J Pharmacol 2013; 170: 440–457. Hu Z-Y, Yang J-L, Cheng C, Huang Y-H, Du F-F, Wang F-Q, Niu W, Xu F, Jiang R-R, Gao X-M, Li C. Combinatorial metabolism notably affects human systemic exposure to ginsenosides from orally administered extract of Panax notoginseng roots (Sanqi). Drug Metab Dispos 2013; 41: 1457–1469. Li L, Zhao Y-S, Du F-F, Yang J-L, Xu F, Ren Y-H, Niu W, Li C. Intestinal absorption and presystemic elimination of various chemical constituents present in GBE50 extract, a standardized extract of Ginkgo biloba leaves. Curr Drug Metab 2012; 13: 494–509. Li C. Editorial: absorption, disposition, and pharmacokinetics of herbal medicines: what and how? Curr Drug Metab 2012; 13: 491–493. Niu W, Zhu X-H, Li L, Yu K, Sun Y, Li C. Nebulizing conditions of pneumatic electrospray ionization significantly influence electrolyte effects on compound measurement. J Mass Spectrom 2012; 47: 370–380. Yang J-L, He M.M, Niu W, Wrighton S.A., Li L, Liu Y, Li C. Metabolic capabilities of cytochrome P450s in Chinese liver microsomes compared with those in Caucasian liver microsomes. Br J Clin Pharmacol 2012; 73: 268–284. Hu Z-Y, Sun Y, Du F-F, Niu W, Xu F, Huang Y-X, Li C. Accurate determination of the anticancer prodrug simmitecan and its active metabolite chimmitecan in various plasma samples based on immediate deactivation of blood carboxylesterases. J Chromatogr A 2011; 1218: 6646–6653. Liu H-F, Yang J-L, Du F-F, Gao X-M, Ma X-T, Huang Y-H, Xu F, Niu W, Wang F-Q, Mao Y, Sun Y, Lu T, Liu C-X, Zhang B-L, Li C. Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats. Drug Metab Dispos 2009; 37: 2290–2298. Sun Y, Dai J-Y, Hu Z-Y, Du F-F, Niu W, Wang F-Q, Liu F, Jin G-Z, Li C. Oral bioavailability and brain penetration of (−)-stepholidine, a tetrahydroprotoberberine agonist at dopamine D1 and antagonist at D2 receptors, in rats. Br J Pharmacol 2009; 158: 1302–1312.