李扬 - 中国科学院上海药物研究所 -

个人简介

教育经历： 1988年9月-1992年7月山东大学，生物化学本科、学士 1996年9月-1999年7月华东师范大学，生理学硕士 1999年9月-2002年7月中国科学院上海药物研究所，药学博士工作经历： 2002年7月-2009年9月美国德克萨斯大学，博士后、研究员 2009年9月-至今中国科学院上海药物研究所，课题组长、博士生导师、研究员

研究领域

研究领域主要包括抗精神疾病的药理机制和新药研发，以及针对突触传递和离子通道的新靶标发现。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Wang QC, Zheng Q, Tan H, Zhang B, Li X, Yang Y, et al. TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel. Cell 2016;165:1454-66. (IF = 29) Zhang X, Wang J, Feng Y, Ge J, Li W, Sun W, et al. Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance. PNAS 2012;109:18180-5. (IF = 9.5) Derebe MG, Zeng W, Li Y, Alam A, Jiang Y. Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore. PNAS. 2011 Jan 11;108(2):592-7. (IF = 9.5) Sheng Ye, Yang Li & Youxing Jiang. Novel insights into K+ selectivity from high-resolution structures of an open K+ channel pore. Nature structural & molecular biology 2010, Vol.17, 1019-1023 (IF = 13.3) Zhou TT, Quan LL, Chen LP, Du T, Sun KX, Zhang JC, et al. SP6616 as a new Kv2.1 channel inhibitor efficiently promotes beta-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways. Cell death & disease 2016;7:e2216. (IF = 5.4) Guo F, Zhang B, Fu Z, Ma Y, Gao Y, Shen F, et al. The rapid antidepressant and anxiolytic-like effects of YY-21 involve enhancement of excitatory synaptic transmission via activation of mTOR signaling in the mPFC. European neuropsychopharmacology 2016;26:1087-98. (IF = 4.5) Chen L, Zhang Q, Qiu Y, Li Z, Chen Z, Jiang H, et al. Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation. Scientific reports 2015;5:15079. (IF = 5.2) Ye D, Li Y, Zhang X, Guo F, Geng L, Zhang Q, et al. TREK1 channel blockade induces an antidepressant-like response synergizing with 5-HT1A receptor signaling. European neuropsychopharmacology 2015;25:2426-36. (IF = 4.5) Geng LY, Ye DQ, Shi YY, Xu Z, Pu MJ, Li ZY, et al. Influence of genetic polymorphisms involved in the hypothalamic-pituitary-adrenal axis and their interactions with environmental factors on antidepressant response. CNS neuroscience & therapeutics 2014;20:237-43. (IF = 4.1) Ning Shi, Weizong Zeng, Sheng Ye, Yang Li* and Youxing Jiang*. Crucial Points within the Pore as Determinants of K+ Channel Conductance and Gating. JOURNAL OF MOLECULAR BIOLOGY, 411(1), pp 27-35, 2011/8/5. (IF = 4.5) Wang JJ, Li Y. KCNQ potassium channels in sensory system and neural circuits. Acta pharmacologica Sinica 2016;37:25-33. Zhang Q, Guo F, Fu ZW, Zhang B, Huang CG, Li Y. Timosaponin derivative YY-23 acts as a non-competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice. Acta pharmacologica Sinica 2016;37:166-76. Guo F, Zhang Q, Zhang B, Fu Z, Wu B, Huang C,. Li Y. Burst-firing patterns in the prefrontal cortex underlying the neuronal mechanisms of depression probed by antidepressants. The European journal of neuroscience 2014; 40 (10): 3538-47. Zhang B, Li Y. Research progress of the antidepressants targeting the glutamate receptors. Chinese Pharmacological Bulletin. 2014，(09):1197-1200 YE Dongqing, ZHANG Zhijun, LI Yang. TREK1potassium channels and depression. Acta Pharmaceutica Sinica. 2012, 47(11):1403-1408.