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个人简介

教育经历 2002.09 - 2005.07 浙江大学药学院 1999.09 - 2002.07 广州中医药大学临床药理研究所 1995.09 - 1999.07 广州中医药大学中药学院 工作经历 2010.07 - 至今 中国科学院上海药物研究所 2008.09 - 2010.06 University of Michigan, Senior Research Fellow 2005.11 - 2008.08 University of Michigan, Research Fellow 社会任职: 1.上海市药学会药剂学专业委员会委员 2.世中联中药药理专业委员会委员 3.世中联经皮给药专业委员会常务理事 4.中药新药与临床药理编委会委员 5.药学学报(中英文版)青年编委 6.中国现代应用药学编委会委员 7.Heliyon 编委 获奖及荣誉: 2011 上海市浦江人才计划 2013 中国药学会-赛诺菲青年生物药物奖 2014 国家自然科学基金优秀青年基金 2016 中和多肽青年科学家奖

研究领域

1.靶向给药系统 2.透皮给药 3.难溶性药物给药技术

近期论文

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Kan XJ, Wang HY, Peng HG, Chen BF, Zhang WY, Wu AH, Xu Q*, Huang YZ*. Mannosylated Liposomal Codelivery of Dihydroartemisinin and Doxorubicin for Drug-Resistant Colon Cancer Therapy. Acta Pharmacologica Sinica, 2017. Accepted. (Serving as Co-Guest Editors for the featured issue) Wang HY, Moon C, Shin MC, Wang YP, He HN, Yang V, Huang YZ*. Heparin-Regulated Prodrug-Type Macromolecular Theranostic Systems for Cancer Therapy. Nanotheranostics, 2017. Accepted Chen YZ, Zhang M, Jin HY, Tang YS, Wu AH, Xu Q, Huang YZ*. Prodrug-like, PEGylated Protein Toxin Trichosanthin for Reversal of Chemoresistance. Molecular Pharmaceutics, 2017, DOI: 10.1021/acs.molpharmaceut.6b00987 Tan J, Wang HY, Xu F, Chen YZ, Zhang M, Peng HG, Sun X*, Huang YZ*. Poly-γ-glutamic acid-based GGT-targeting and surface camouflage strategy for improving cervical cancer gene therapy. Journal of Materials Chemistry B, 2017,5: 1315-1327 Chen YZ, Zhang M, Jin HY, Tang YS, Wang HY, Xu Q, Li YP, Li F, Huang YZ*. Intein-mediated site-specific synthesis of tumor-targeting protein delivery system: Turning PEG dilemma into prodrug-like feature. Biomaterials 2017, 116: 57-68 Lin TT, Zhao PF, Jiang YF, Tang YS, Jin HY, Pan ZZ, He HN, Yang V, Huang YZ*. Blood–Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy. ACS Nano 2016, 10:9999–10012 Cui YN, Zhang M, Zeng F, Jin HY, Xu Q, Huang YZ*. Dual-targeting magnetic PLGA nanoparticles for codelivery of paclitaxel and curcumin for brain tumor therapy. ACS Applied Materials & Interfaces 2016, 8: 32159-32169 Pan ZZ, Wang HY, Zhang M, Lin TT, Zhang WY, Zhao PF, Tang YS, Xiong Y, Zeng YE* and Huang YZ*. Nuclear-targeting TAT-PEG-Asp8-doxorubicin polymeric nanoassembly to overcome drug-resistant colon cancer. Acta Pharmacologica Sinica 2016, 37: 1110–1120 (Editor choice) Lin TT, Liu EG, He HN, Shin MC, Moon C, Yang V*, Huang YZ*. Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides. Acta Pharmaceutica Sinica B 2016, 6: 352–358 (Back cover story) Liang JM, Zeng F, Zhang M, Pan ZZ, Chen YZ, Zeng YE, Xu Y, Xu Q*, Huang YZ*. Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44+ cancer cells. RSC Advances 2015,5, 43733-43740 Wang HY, Jiang YF, Peng HG, Chen YZ, Zhu PZ, Huang YZ*. Recent Progress in microRNA Delivery for Cancer Therapy by Non-viral Synthetic Vectors. Advanced Drug Delivery Reviews 2015, 81:142-60 Wang YP, Lin TT, Zhang WY, Jiang YF, Jin HY, Yang VC, Chen Y and Huang YZ*. A Prodrug-type, MMP-2-targeting Nanoprobe for Tumor Detection and Imaging. Theranostics 2015, 5:787-795 Hu Y, Xu BH, Xu JJ, Shou D, Liu EG, Gao JQ, Liang WQ, and Huang YZ*, Microneedle-assisted Dendritic Cell-targeted Nanoparticles for Transcutaneous DNA Immunization. Polymer Chemistry 2015, 6: 373-379 (Front Cover Story) Jiang YF, Lu JY, Wang YP, Zeng F, Wang HY, Peng HG, Huang M, Jiang HL, Luo C* and Huang YZ*, Molecular-Dynamics-Simulation-Driven Design of a Protease-Responsive Probe for In Vivo Tumor Imaging. Advanced Materials 2014, 26: 8174-8 Wang HY, Wang HX, Liang JM, Jiang YF, Guo QQ, Peng HG, Xu Q, Huang YZ*. Cell-penetrating Apoptotic Peptide/p53 DNA Nanocomplex as Adjuvant Therapy for Drug-resistant Breast Cancer. Molecular Pharmaceutics 2014, 11:3352-60 Wang HY, Li F*, Du C, Wang HX, Mahato RI, Huang YZ*. Doxorubicin and Lapatinib Combination Nanomedicine for Treating Resistant Breast Cancer. Molecular Pharmaceutics 2014, 11: 2600-11. (Serving as Co-Guest Editors for the featured issue) Wang HX, Zhao YX, Wang HY, Gong JB, He HN, Yang V*, Huang YZ*. Low-Molecular-Weight Protamine-Modified PLGA Nanoparticles for Overcoming Drug-Resistant Breast Cancer. Journal of Controlled Release 2014, 192: 47–56 Wang YP, Jiang YF, Zhang M, Tan J, Liang JM, Wang HX, Li YP, He HN, Yang V*, Huang YZ*. Protease-activatable Hybrid Nanoprobe for Tumor Imaging. Advanced Functional Materials 2014, 24: 5443-53. Tan J, Cheong HS, Park YS, Kim HG, Zhang M, Moon C* and Huang YZ*. Cell-Penetrating Peptide-Mediated Topical Delivery of Biomacromolecular Drugs. Current Pharmaceutical Biotechnology. 2014, 15(3):231-9 (Serving as Guest Editor for the featured issue) Wang Z, Chen YZ, Liu EG, Gong JB, Shin MC, Huang YZ*. CPP-mediated Protein Delivery in a Noncovalent Form: Proof-of-Concept for Percutaneous and Intranasal Delivery. Protein Peptide Letters 2014, 21:1129-36.

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