蓝乐夫 - 中国科学院上海药物研究所 -

个人简介

以重要人类病原菌金黄色葡萄球菌（简称金葡菌）、铜绿假单胞菌等为研究对象，利用遗传学、分子生物学、化学生物学等学科手段来研究细菌毒力因子表达的遗传及小分子调控，阐释病原细菌致病力调节的分子机理、探索抗细菌感染的药物作用新靶点。近5年来（2012—至今）在Nat. Chem. Biol., Proc Natl Acad Sci USA, PLOS Pathogens, Mol. Microbiol, Nucleic Acids Res. J Med Chem. J Biol Chem.等杂志发表通讯（共同通讯）作者学术论文10余篇。申请专利4项（其中2项已实施转让）。目前主持国家自然科学基金面上项目2项。现任国际学术期刊Virulence杂志（IF2015=5.418）编委(2015-2017)、上海市微生物学会理事（2015.10-2019.9）。工作经历 2010.05 - 至今中国科学院上海药物研究所，研究员，研究组长 2007.01 - 2010.05 芝加哥大学，化学系，博士后 2004.10 - 2006.12 堪萨斯州立大学，植物病理系，博士后

研究领域

抗细菌感染新药发现中的细菌学及化学生物学研究： 1. 细菌致病性的分子机理 2. 抗细菌感染潜在新靶标的发现及验证 3. 抗毒力药物(Anti-virulence drugs)

近期论文

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Wang Y#, Di H#, Chen F, Xu Y, Xiao Q, Wang X, Wei H, Lu Y, Zhang L, Zhu J, Lan L*, Li J*. Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN). J Med Chem. 2016 May 26;59(10):4831-48. Wang Y#, Chen F#, Di H, Xu Y, Xiao Q, Wang X, Wei H, Lu Y, Zhang L, Zhu J, Sheng C, Lan L*, Li J*. Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections. J Med Chem. 2016 Apr 14;59(7):3215-30. [ACS Editors' Choice® Articles; highlighted by BioCentury Innovations, 03/31/2016]. Chen F#, Di H#, Wang Y#, Cao Q, Xu B, Zhang X, Yang N, Liu G, Yang CG, Xu Y, Jiang H, Lian F, Zhang N, Li J*, Lan L*. Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence. Nat Chem Biol. 2016 Mar;12(3):174-9. [Highlighted by Nature Reviews Drug Discovery, (doi:10.1038/nrd.2016.35), Bioworld Today (01/20/2016), and BioCentury Innovations (01/28/2016)]. Yang N, Lan L*. Pseudomonas aeruginosa Lon and ClpXP proteases: roles in linking carbon catabolite repression system with quorum-sensing system. Curr Genet. 2016 Feb;62(1):1-6. Yang N, Ding S, Chen F, Zhang X, Xia Y, Di H, Cao Q, Deng X, Wu M, Wong CC, Tian XX, Yang CG, Zhao J, Lan L*. The Crc protein participates in down-regulation of the Lon gene to promote rhamnolipid production and rhl quorum sensing in Pseudomonas aeruginosa. Mol Microbiol. 2015 May;96(3):526-47. Ding Y, Liu X, Chen F, Di H, Xu B, Zhou L, Deng X, Wu M, Yang CG*, Lan L*. Metabolic sensor governing bacterial virulence in Staphylococcus aureus. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4981-90. [Highlighted by SciBX, 7(46); doi:10.1038/scibx.2014.1352] Cao Q#, Wang Y#, Chen F, Xia Y, Lou J, Zhang X, Yang N, Sun X, Zhang Q, Zhuo C, Huang X, Deng X, Yang CG, Ye Y, Zhao J*, Wu M*, Lan L*. A novel signal transduction pathway that modulates rhl quorum sensing and bacterial virulence in Pseudomonas aeruginosa. PLoS Pathog. 2014 Aug 28;10(8):e1004340. Deng X#, Liang H#, Chen K, He C, Lan L*, Tang X*. Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae. Nucleic Acids Res. 2014 Oct;42(18):11472-86. 陈菲菲, 狄红霞, 蓝乐夫*. 金黄色葡萄球菌重要毒力因子的功能及其抑制剂研究进展,科学通报，2013, 58: 3743-3752. Liu X, Sun X, Wu Y, Xie C, Zhang W, Wang D, Chen X, Qu D, Gan J, Chen H, Jiang H, Lan L*, Yang CG*. Oxidation-sensing regulator AbfR regulates oxidative stress responses, bacterial aggregation, and biofilm formation in Staphylococcus epidermidis. J Biol Chem. 2013 Feb 8;288(6):3739-52. Sun F, Ding Y, Ji Q, Liang Z, Deng X, Wong CC, Yi C, Zhang L, Xie S, Alvarez S, Hicks LM, Luo C, Jiang H, Lan L*, He C*. Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15461-6. Highlighted by Sci. Signal. DOI: 10.1126/scisignal.2003635）