吴蓓丽 - 中国科学院上海药物研究所 -

研究领域

主要从事G蛋白偶联受体（GPCR）的结构生物学研究，研究工作集中在以下几个方面： 1. GPCR高分辨率晶体结构解析； 2. GPCR三维结构与功能关系的研究； 3. 基于GPCR结构的药物设计与研发近期及未来研究方向：针对重要的GPCR蛋白开展晶体结构测定工作，为新配体发现提供结构依据，深入研究GPCR介导信号转导的分子机制，为相关功能研究提供新线索。

近期论文

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Beili Wu, Ellen Y. T. Chien, Clifford D. Mol, Gustavo Fenalti, Wei Liu, VsevolodKatritch, Ruben Abagyan, Alexei Brooun, Peter Wells, F. Christopher Bi, Damon J. Hamel, Peter Kuhn, Tracy M. Handel, VadimCherezov, Raymond C. Stevens*. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science. 2010;330: 1066-1071. Qiang Zhao*, Beili Wu. Ice breaking in GPCR structural biology.ActaPharmacol Sin. 2012; 33(3): 324-334. Qiuxiang Tan, Ya Zhu, Jian Li, Zhuxi Chen, Gye Won Han, Irina Kufareva, Tingting Li, Limin Ma, Gustavo Fenalti, Jing Li, Wenru Zhang, XinXie, Huaiyu Yang, Hualiang Jiang, VadimCherezov, Hong Liu, Raymond C. Stevens, Qiang Zhao, Beili Wu*. Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science. 2013;341: 1387-1390. Lan Zhu, Qiang Zhao &Beili Wu*. Structure-based studies of chemokine receptors. CurrOpinStruct Biol. 2013; 23: 539-546. Jin Zhang, Kaihua Zhang, Zhan-GuoGao, Silvia Paoletta, Dandan Zhang, Gye Won Han, Tingting Li, Limin Ma, Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang, VadimCherezov, VsevolodKatritch, Kenneth A. Jacobson, Raymond C. Stevens, Beili Wu* &Qiang Zhao*. Agonist-bound structure of the human P2Y12 receptor. Nature. 2014;509: 119-122. Kaihua Zhang, Jin Zhang, Zhan-GuoGao, Dandan Zhang, Lan Zhu, Gye Won Han, Steven M. Moss, Silvia Paoletta, EvgenyKiselev, Weizhen Lu, Gustavo Fenalti, Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang, VadimCherezov, VsevolodKatritch, Kenneth A. Jacobson, Raymond C. Stevens, Beili Wu&Qiang Zhao*. Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature. 2014;509: 115-118.