个人简介

Outstanding Faculty Award, Honors College, 2011 Weed Endowed Chair, 2008 NSF CAREER Award, 2006 Research Innovation Award, 2002 Leukemia Society Fellow, 1999

研究领域

Biochemistry/Organic/""Metabolism/Signaling/and Regulation""/Bioanalytical/Bioorganic/Chemical Biology/Materials and Polymer Chemistry/Nucleic Acids and Genomes/Protein and Membrane Biochemistry/Structure

Bioorganic Chemistry and Chemical Biology Our group focuses upon: A) Designing Inhibitors of Protein/Protein Interactions B) Constructing Macromolecules and Quantum Dots with Novel Functions C) Designing Split-Protein Biosensors

近期论文

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Jester, B.W.; Gaj, A.; Shomin, C.D.; Cox, K.J.; Ghosh, I."Testing the Promiscuity of Commercial Kinase Inhibitors against the AGC Kinase Group Using a Split-luciferase Screen" J. Medicinal Chemistry , 2012, ASAP Shekhawat, S.S.; Ghosh, I."Split-Protein Systems: Beyond Binary Protein-Protein Interactions" Current Opinion in Chemical Biology , 2011, 15,789-797 Shomin, C.D.; Resituto, E.; Cox, K.J.; Ghosh, I."Selection of cyclic-peptide inhibitors targeting Aurora kinase A: Problems and solutions." Bioorg. Med. Chem., 2011,19,6743-6749 Badran, A.H.; Furman, J.L.; Ma, A.S.; Comi, T.J.; Porter, J.R.; Ghosh, I."Evaluating the Global CpG Methylation Status of Native DNA Utilizing a Bipartite Split-Luciferase Sensor" Analytical Chem., 2011,83, 7151-7157 Shekhawat, S.S.; Campbell, S.T.; Ghosh, I. "A Comprehensive Panel of Turn-on Caspase Biosensors for Investigating Caspase Specificity and Caspase Activation Pathways" ChemBioChem, 2011,12,2353-2364 Furman, J.L.; Mok, P.W.; Badran, A.H.; Ghosh, I. "Turn-on DNA Damage Sensors for the Direct Detection of 8-Oxoguanine and Photoproducts in Native DNA" J. Am. Chem. Soc., 2011,133, 12518-12527(Journal Cover) Kox, K.J.; Shomin, C.D.; Ghosh, I."Tinkering outside the kinase ATP box: allosteric (type IV) and bivalent (type V) inhibitors of protein kinases" Future Med. Chem. , 2011, 3, 29-43 Furman, J.L.; Mok, P.W.;Shen,S.; Stains, C. I.; Ghosh, I. "A turn-on split-luciferase sensor for the direct detection of poly(ADP-ribose) as a marker for DNA repair and cell death" Chem. Commun., 2011, 47, 397-399 Porter, J.R;Helmers, M.H.;Wang, P.; Furman, J.L.; Arora, P.S.; Ghosh, I. "Profiling Small Molecule Inhibitors against Helix-Receptor Interactions: The Bcl-2 Family Inhibitor BH3I-1 Potently Inhibits p53/hDM2" Chem. Commun., 2010,46, 8020-8022 Jester, B.W.;Cox, K.J.;Gaj, A.; Shomin, C.D.; Porter, J.R.; Ghosh, I. "A Coiled Coil Enabled Split-Luciferase Three-Hybrid System: Applied Toward Profiling Inhibitors of Protein Kinases" J. Am. Chem. Soc., 2010, 132, 11727-11735 Furman, J.L.;Badran A.H.;Oluyomi A.; Porter, J.R.; Stains, C.I.; Segal, D.J.; Ghosh, I. "A General Approach toward RNA-Templated Hierarchical Assembly of Split-Proteins" J. Am. Chem. Soc., 2010, 132, 11692-11701 Stains, C.I.; Furman, J.L.; Porter, J.R.; Rajagopal, S.; Yuxing, L.; Wyatt, R.T.; Ghosh, I. "A General Approach for Receptor and Antibody-Targeted Detection of Native Proteins utilizing Split-Luciferase Reassembly" ACS Chemical Biology, 2010, 5, 943-952 Henchey, L.K.; Porter, J.R.; Ghosh, I.; Arora, P.S."High Specificity in Protein Recognition by Hydrogen Bond Surrogate alpha-Helices: Selective Inhibition of the p53/MDM2 Complex" ChemBioChem, 2010, 11,2104-2107 Yu, Y.; Blair, S.; Gillespie, D.; Jensen, R.; Myszka, D.; Badran, A.H.; Ghosh, I.; Chagovetz, A. "Direct DNA Methylation Profiling Using Methyl Binding Domain Proteins" Analytical Chemistry, 2010, 82, 5012-5019 Meyer, S.C.; Ghosh, I. "Phage Display Technology in Biosensor Development" In Recognition Receptors in Biosensors; Zourob, M., Ed. Springer: New York; 2010, 723-751 Porter J.R.; Lockwood S.H.; Segal. D.J.; Ghosh, I."Seeing Genetic and Epigenetic Information without DNA Denaturation Using Sequence Enabled Reassembly (SEER)" Engineered Zinc Finger Proteins: Protocols and Methods: Methods in Molecular Biology 649 Springer: New York; 2010, 649, 365-382 Shekhawat, S.S.; Porter, J.R.; Sriprasad, A.; Ghosh, I."An Autoinhibited Coiled-Coil Design Strategy for Split-Protein Protease Sensors" J. Am. Chem. Soc., 2009, 131, 5284-5290 Furman, J.L.;Badran, A.H.; Shen, S.; Stains, C.I.;Hannallah, J.; Segal D.J.; Ghosh, I. "Systematic Evaluation of Split-fluorescent Proteins for the Direct Detection of Native and Methylated DNA" Bioorg. Med. Chem. Lett., 2009, 19, 3748-51 (special issue for Carlos F. Barbas III/featured Report in Faculty of 1000) Shomin, C.D.; Meyer, S.C.; Ghosh, I. "Staurosporine Tethered Peptide Ligands that Target cAMP-Dependent Protein Kinase (PKA): Optimization and Selectivity Profiling" Bioorg. Med. Chem., 2009, 17, 6196-202 Deng, Z.; Lie, L.F.; Shen, S.; Ghosh, I.; Mansuripur, M; Muscat, A. J. "Water-Based Route to Ligand-Selective Synthesis of ZnSe and Cd-Doped ZnSe Quantum Dots with Tunable Ultraviolet A to Blue Photoluminescence" Langmuir 2009, 9, 434-442 Porter, J.R.; Stains, C.I.; Jester, B.W.; Ghosh, I. "A General and Rapid Cell-Free Approach for the Interrogation of Protein-Protein, Protein-DNA and Protein-RNA Interactions and their Antagonists Utilizing Split-Protein Reporters"J. Am. Chem. Soc. 2008, 130, 6488-6497