赵强 - 中国科学院上海药物研究所 -

研究领域

从事基于G蛋白偶联受体（GPCR）的高分辨率结构解析以及基于结构的新药发现等研究，主要集中在以下几个方向： 1.GPCR结构解析新技术开发与应用； 2.心血管疾病、自身免疫病、代谢性疾病中的关键GPCR的结构解析及其作用机制研究，以及基于结构的新药开发； 3.GPCR与下游分子的复合物结构研究。

近期论文

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Chien E, Liu W, Zhao Q, Katritch V, Han GW, Hanson M, Shi L, Newman A, Javitch J, Cherezov V, Stevens R*. Structure of the Human Dapamine D3 Receptor in Complex with a D2/D3 Selective Antagonist. Science. 2010; 330(6007): 1091-5. Qiang Zhao*, Beili Wu. Ice breaking in GPCR structural biology. Acta Pharmacol Sin. 2012; 33(3): 324-334. Yang N, Wang W, Wang Y, Wang M, Zhao Q, Rao Z, Zhu B, Xu RM*.Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1. Proc Natl Acad Sci U S A. 2012; 109(44):17954-9. Qiuxiang Tan, Ya Zhu, Jian Li, Zhuxi Chen, Gye Won Han, Irina Kufareva, Tingting Li, Limin Ma, Gustavo Fenalti, Jing Li, Wenru Zhang, Xin Xie, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Hong Liu, Raymond C. Stevens, Qiang Zhao, Beili Wu*. Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science. 2013; 341: 1387-1390. Lan Zhu, Qiang Zhao & Beili Wu*. Structure-based studies of chemokine receptors. Curr Opin Struct Biol. 2013; 23: 539-546. Jin Zhang, Kaihua Zhang, Zhan-Guo Gao, Silvia Paoletta, Dandan Zhang, Gye Won Han, Tingting Li, Limin Ma, Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Vsevolod Katritch, Kenneth A. Jacobson, Raymond C. Stevens, Beili Wu* & Qiang Zhao*. Agonist-bound structure of the human P2Y12 receptor. Nature. 2014; 509: 119-122. Kaihua Zhang, Jin Zhang, Zhan-Guo Gao, Dandan Zhang, Lan Zhu, Gye Won Han, Steven M. Moss, Silvia Paoletta, Evgeny Kiselev, Weizhen Lu, Gustavo Fenalti, Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Vsevolod Katritch, Kenneth A. Jacobson, Raymond C. Stevens, Beili Wu & Qiang Zhao*. Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature. 2014; 509: 115-118.