任进 - 中国科学院上海药物研究所 -

研究领域

1. 符合国际GLP要求的药物非临床安全性评价研究（化药、生物技术药和中药的申报新药实验报告） 2. 新药的早期毒性筛选，以提高新药研发的成功率、降低风险 3. 生物技术药物（单抗、ADC抗体、核酸类药物等）的特殊关键技术评价、分析和研究 4. 针对药物的重要靶器官肝脏、肾脏、心脏等毒性机制研究 5. 探索创新药物的新技术、新方法、新模型的开发和应用

近期论文

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Jun YAO1, Cheng-gang LI1, Li-kun GONG1, Chen-chen FENG1,Chun-zhu LI1, Man GAO1, Yang LUAN1, Xin-ming QI1,*, Jin REN1,*. Hepatic cytochrome P450s play a major role in monocrotaline-induced renal toxicity in mice. Acta Pharmacologica Sinica, 2014, 35(2):292-300. (IF=2.354) Guo C, He L, Yao D, A J, Cao B, Ren J, Wang G, Pan G. Alpha-naphthylisothiocyanate modulates hepatobiliary transporters in sandwich-cultured rat hepatocytes. Toxicology Letters. 2014, 224(1):93-100. (IF=3.666) Xin-ming QI 1,ǂ, Ling-ling MIAO1,ǂ, Yan CAI1 , Li-kun GONG1, *, Jin REN 1, *. ROS generated by Cyp450, especially Cyp2e1, mediated mitochondrial dysfunction induced by tetrandrine in rat hepatocytes. Acta Pharmacologica Sinica 2013; 34:1229-1236 . (IF=2.354) Xiaofeng Xie 1, ǂ , Lingling Miao1, ǂ, Jun Yao 1, Chenchen Feng 1, Chenggang Li1, Man Gao 1, Mingxia Liu1, Likun Gong 1, Yizheng Wang2, Xinming Qi 1, *, Jin Ren 1, *. Role of multiple microRNAs in the sexually dimorphic expression of Cyp2b9 in mouse liver. Drug Metabolism and Disposition, 2013; 41(10):1732-1737. (IF=3.361) Cheng Y, Liu Y, Wang H, Li J, Ren J, Zhu L, Gong L*. A 26-week repeated dose toxicity study of Xian-ling-gu-bao in Sprague-Dawley rats. J Ethnopharmacol. 2012,145(1):85-93. (IF=3.014) Wu M, Xing G, Qi X, Feng C, Liu M, Gong L, Luan Y, Ren J. Assessment of the mutagenic potential of arecoline in gpt delta transgenic mice. Mutat Res. 2012; 748(1-2): 65-9. (IF=3.035) Luan Y, Xing G, Qi X, Wu M, Li C, Yao J, Gong L, Nohmi T, Gu J, Zhou W, Zheng S, Ren J. The application of hepatic P450 reductase null gpt delta mice in studying the role of hepatic P450 in genotoxic carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mutagenesis. Arch Toxicol. 2012; 86(11): 1753-61. (IF=4.674) Wu, Y., Qi, X., Gong, L., Xing, G., Xue, X., Li, Y., Chen, M., Yao, J., Miao, L., Luan, Y*. and Ren, J*. Identification of BC005512 as a DNA Damage Responsive Murine Endogenous Retrovirus of GLN Family Involved in Cell Growth Regulation. Plos one. 2012;7(4):e35010 (IF=4.411) Luan Y, Kogi M, Rajaguru P, Ren J, Yamaguchi T, Suzuki K, Suzuki T. Microarray analysis of responsible genes in increased growth rate in the subline of HL60 (HL60RG) cells. Mutat. Res.-Fundam. Mol. Mech. Mutagen. 2012, 1;731(1-2):20-6. (IF=3.556) Guozhen Xing1,2, Xinming Qi1, Min Chen1,2, Yuanfeng Wu1,2, Jun Yao1,2, Likun Gong1, Takehiko Nohmi3,Yang Luan1*, and Jin Ren1* . Comparison of the mutagenicity of aristolochic acid I and aristolochic acid II in the gpt delta transgenic mouse kidney. Mutat Res. 2012(743):52-58.(IF=3.035) Xue X, Gong LK, Maeda K, Luan Y, Qi XM, Sugiyama Y, Ren J. Critical Role of Organic Anion Transporters 1 and 3 in Kidney Accumulation and Toxicity of Aristolochic Acid I. Molecular Pharmaceutics 2011,8(6):2183-92. (IF=5.40) Chen M, Gong L, Qi X, Xing G, Luan Y, Wu Y, Xiao Y, Yao J, Li Y, Xue X, Pan G,Ren J. Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity. Toxicological Sciences. 2011,122(2):288-96. (IF=5.093) Xia Liu, Xiang Xue, Likun Gong, Xinming Qi, Yuanfeng Wu, Guozhen Xing, Yang Luan, Ying Xiao, Xiongfei Wu, Yan Li, Min Chen, Lingling Miao, Jun Yao, Jun Gu, Donghai Lin, Jin Ren. 1H NMR-Based Metabolomic Analysis of Triptolide-Induced Toxicity in Liver-Specific Cytochrome P450 Reductase Knockout Mice. Metabolomics 2012(8):907-918. (IF=3.608) Xiang Xuea, Likun Gonga*, Xinming Qia, Yuanfeng Wua, Guozhen Xinga, Jun Yaoa,Yang Luana, Ying Xiaoa, Yan Lia, Xiongfei Wua, Min Chena, Jun Gub, and Jin Rena, *. Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity. Toxicol Lett. 2011,205(1):47-54. (IF= 3.581) Yan Li, Yang Luan, Xinming Qi, Zhi Chen, Ming Li1, Xia Liu, Likun Gong, Xiang Xue, Yuanfeng Wu, Min Chen, Guozhen Xing, Xiongfei Wu, Lingling Miao, Jun Yao , Jin Ren. Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II. Toxicological Sciences 2010(118(2)): 435–443（IF= 5.093） Yan Li, Xin-ming Qi, Xiang Xue, Xiong-fei Wu, Yuan-feng Wu, Min Chen, Guo-zhen Xing, Yang Luan and Jin Ren. The relationship between diphenylamine structure and NSAIDs-induced hepatocytes injury. Toxicology Letters . 2009,186(2):111-4 (IF= 3.581)