陈笑艳 - 中国科学院上海药物研究所 -

研究领域

1.与药物不良反应相关的药物代谢/转运机制研究； 2.药物代谢新途径化学和生物学基础研究； 3.创新药物相关的药物代谢与动力学新方法研究； 4.药物代谢和动力学研究平台建设。

近期论文

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Zhong K, Li XL, Xie C, Zhang YF, Zhong DF, Chen XY*. Effects of renal impairment on the pharmacokinetics of morinidazole: uptake transporter-mediated renal clearance of the conjugated metabolites. Antimicrob Agents Chemother, 2014, doi:10.1128/AAC.02414-14 Diao XX, Pang XY, Xie C, Guo ZT, Zhong DF, Chen XY*. Bioactivation of 3-n-Butylphthalide (NBP) via Sulfation of Its Major Metabolite 3-Hydroxy-NBP: Mediated Mainly by Sulfotransferase 1A1. Drug Metab Dispos, 42: 774-81, 2014 Xie C, Zhong DF, Chen XY*. A fragmentation-based method for the differentiation of glutathione conjugates by high-resolution mass spectrometry with electrospray ionization. Anal Chim Acta, 788: 89-98, 2013 Deng P, Zhong DF, Yu K, Zhang YF, Wang T, Chen XY*. Pharmacokinetics, metabolism, and excretion of the antiviral drug arbidol in humans. Antimicrob Agents Chemother, 574: 1743-1755, 2013 Diao XX, Deng P, Xie C, Li XL, Zhong DF, Zhang YF, Chen XY*. Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation. Drug Metab Dispos, 41: 430-444, 2013 Xie C, Zhou JL, Guo ZT, Diao XX, Gao ZW, Zhong DF, Jiang HY, Zhang LS, Chen XY*. Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Brit J Pharmacol, 168: 1687-1706, 2013 Chen MX, Liu K, Zhong DF, Chen XY*. Trimethylsilyldiazomethane derivatization coupled with solid-phase extraction for the determination of alendronate in human plasma by LC-MS/MS. Anal Bioanal Chem, 402: 791-798, 2012 Xie C, Zhong DF, Chen XY*. Identification of the ortho-benzoquinone intermediate of 5-O-caffeoylquinic acid in vitro and in vivo: Comparison of bioactivation under normal and pathological situations. Drug Metab Dispos, 40: 1628-1640, 2012 Gao RN, Li L, Xie C, Diao XX, Zhong DF, Chen XY*. Metabolism and pharmacokinetics of morinidazole in humans: Identification of diastereoisomeric morpholine N+-glucuronides catalyzed by UDP-glucuronosyl- transferase 1A9. Drug Metab Dispos, 40: 556-567, 2012 Jin H, Li L, Zhong DF, Liu J, Chen XY*, Jiang Zheng*. Pulmonary toxicity and metabolic activation of tetrandrine in CD-1 Mice. Chem Res Toxicol, 24, 2142-2152 , 2011 Deng P, Zhong DF, Nan FJ, Liu S, Li D, Yuan T, Chen XY*, Zheng J*. Evidence for the bioactivation of 4-nonyphenol to quinine methide and ortho-benzoquinone metabolites in human liver microsomes. Chem Res Toxicol, 23: 1617-1628, 2010 Wang YY, Zhong DF, Chen XY*, Zheng J*. Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile. Chem Res Toxicol, 22: 824-834, 2009 Chen XY. Profiling and characterization of bioactive substances of herbal medicine and their metabolites using mass spectrometry. In: Handbook of Metabolic Pathways of Xenobiotics, edited by Lee PW, Aizawa H, Gan LL, Prakash C, Zhong DF. John Wiley & Sons, Ltd., Volume 2, 2014