南发俊 - 中国科学院上海药物研究所 -

个人简介

南发俊，国家杰出青年基金获得者，现任中国科学院上海药物研究所研究员，国家化合物样品库副主任。1991年毕业于兰州大学化学系，获理学学士学位。1997年于中国科学院上海有机化学研究所获理学博士学位。工作经历 2000.6－至今中国科学院上海药物研究所，研究员，课题组长 1997.08－2000.05 美国乔治城大学医学中心(Georgetown University Medical Center)，博士后

研究领域

(1)新分子实体发现及药物构效关系研究 (2)探针工具的设计合成

近期论文

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Shu-Wei Zhang; Chao-Jun Gong; Ming-Bo Su; Fei Chen; Ting He; Yang-Ming Zhang; Qian-Qian Shen; Yi Su; Jian Ding; Jia Li*; Yi Chen*; Fa-Jun Nan*; Synthesis and in Vitro and in Vivo Biological Evaluation of Tissue-Specific Bisthiazole Histone Deacetylase (HDAC) Inhibitors, J. Med. Chem., 2020, 63(2): 804-815. Yang Zhan, Xiao-Wei Zhang, Ying Xiong, Bo-Liang Li, Fa-Jun Nan, , Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2) , Organic & Biomolecular Chemistry, 2016, 14(2): 747~751 Huayan Chen, Hui Yang, Zhilong Wang, Xin Xie*, Fa-Jun Nan*. Discovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT1Selective Antagonists. ACS Med. Chem. Lett. 2016,7, 335-339. Fei Chen, Hui Chai, Ming-Bo Su, Yang-Ming Zhang, Jia Li*, XinXie*, Fa-Jun Nan*. Potent and Orally Efficacious Bisthiazole-Based Histone Deacetylase Inhibitors. ACS Med. Chem. Lett. 2014, 5, 628-633. Li-Fang Yu, Yuan-Yuan Li, Ming-Bo Su, Mei Zhang, Wei Zhang, Li-Na Zhang, Tao Pang, Run-Tao Zhang, Bing Liu, Jing-Ya Li*, Jia Li*, Fa-Jun Nan*, Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators ACS Med. Chem. Lett. 2013.5, 4(5): 475~480